ABSORBED DOSE MEASURMENTS USING POLYMER/GEL CHAMBERS

使用聚合物/凝胶室测量吸收剂量

基本信息

批准号：
2436523
负责人：
MAREK J MARYANSKI
金额：
$ 9.43万
依托单位：
MGS RESEARCH, INC.
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-06-01 至 1999-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2436523
关键词：
biomedical equipment development biotechnology gel ionization method development nuclear magnetic resonance spectroscopy particle beam polymers radiation dosage

项目摘要

DESCRIPTION: The investigators propose to test the feasibility of developing a gel-based dosimeter with tissue mimicking properties that would be read by change in NMR or optical signal due to an X-ray dose- related polymerization, as further described by their abstract: "This proposal aims to develop tissue-equivalent polymer-gel chambers as substitutes for conventional ionization chambers, and to establish the feasibility of designing simple photometers or bench-top NMR relaxometers to measure radiation doses accurately. X-ray, electron and heavy-charged-particle beams are routinely calibrated with ionization chambers, which present a complex theoretical problem: how to convert the electrical charge from air ionization to the energy absorbed per mass of tissue. The calibration of radiations above 1 MeV requires that the ionization chamber first be calibrated for 60Co gamma rays at a national or regional laboratory. Subsequently, this calibration factor and as many as a dozen other chamber-and radiation-dependent parameters are applied to obtain the tissue dose. The uncertainty in the tissue- dose determination is + 3%. The polymer-gel dosimeter is tissue (muscle) equivalent so that, after calibration at one energy, the dose-to-muscle at another energy is obtained without complex corrections. The overall goal of the proposed research is to demonstrate that small polymer-gel chambers can be reliably constructed and used to calibrate radiation bemas, and to design the instrumentation (optical or NMR relaxation measuring devices) needed to provide a novel, clinical dosimetry system." PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述：调查人员建议测试开发具有模仿组织特性的基于凝胶的剂量表由于X射线剂量 - 相关聚合，如其摘要进一步描述： “该建议旨在发展组织等效的聚合物凝胶室作为常规电离室的替代品，并建立设计简单的光度计或台式NMR的可行性放松计，以准确测量辐射剂量。 X射线，电子和重音粒子光束通常用电离校准钱伯斯，这是一个复杂的理论问题：如何转换从空气电离到吸收能量的电荷组织的质量。辐射的校准以上1 MEV需要电离室首先在60co gamma射线上校准国家或地区实验室。随后，该校准因子以及多达十几个其他室和辐射依赖性参数用于获得组织剂量。组织的不确定性剂量确定为 + 3％。聚合物 - 凝胶剂量表是组织（肌肉）等效，以便在一个能量校准后，剂量到肌肉在另一个能量下，没有复杂的校正。总体拟议的研究的目标是证明小聚合物凝胶可以可靠地构造并用来校准辐射 bemas并设计仪器（光学或NMR放松测量设备）需要提供一种新颖的临床剂量测定法系统。” 拟议的商业应用程序：不可用

项目成果

期刊论文数量（2）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Chiral CE separation of dopamine-derived neurotoxins.

多巴胺衍生神经毒素的手性毛细管电泳分离。

DOI：
10.2116/analsci.21.115
发表时间：
2005
期刊：
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry
影响因子：
0
作者：
Quan,Zhe;Song,Yaru;Peters,Gladys;Shenwu,Ming;Sheng,Yinghong;Hwang,Huey-Min;Liu,Yi-Ming
通讯作者：
Liu,Yi-Ming

Synthesis and structure-activity correlation studies of metal complexes of alpha-N-heterocyclic carboxaldehyde thiosemicarbazones in Shewanella oneidensis.

希瓦氏菌α-N-杂环甲醛缩氨基硫脲金属配合物的合成及构效相关研究。