AUTOMATED VERIFICATION SYSTEM FOR CONFORMAL RTP AND IMRT

适用于适形 RTP 和 IMRT 的自动验证系统

• 批准号: 2870281
• 负责人: MAREK J MARYANSKI
• 金额: $ 9.14万
• 依托单位: MGS RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-15 至 2000-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2870281
• 关键词: biomedical automation; computer human interaction; computer program /software; computer system design /evaluation; magnetic resonance imaging; mathematical model; neoplasm /cancer radiation therapy; patient care planning; phantom model; radiation dosage

The use of 3D RTP and IMRT is increasing for patient dose escalation. The major stumbling block to the growth and universal acceptance of these high-tech methods is the lack of available methods to verify that the planned dose will be delivered to the patient correctly. MGS Research Incorporated has developed tissue-equivalent BANG(R) gels that can record permanent images of complete 3D dose distributions of ionizing radiations at therapeutic doses. Dose distributions in BANG gels can be measured with high spatial accuracy and precision using magnetic resonance imaging (MRI). Having verified the potential utility of BANG gel dosimetry for radiation therapy, MGS Research intends to create, in collaboration with SUNY at Stony Brook, a completely automated 3-D conformal RTP and IMRT verification system based on the use of BANG gel phantoms and MRI. Our system will be the only tool available for this purpose and thus we anticipate a sizeable demand. The long-term goal of this project is to deliver a unique product consisting of 1) DICOM-RT compatible software module capable of creating 3D dose data sets from MRI scans of irradiated BANG gel phantoms and of correlating those with the treatment plan data (Phases I and II), 2) a series of specially designed phantoms containing BANG gel inserts and MRI- and CT-sensitive structures (Phase II), and 3) MRI scanning and gel analysis service for customers using BANG gel dosimeters (Phase III). PROPOSED COMMERCIAL APPLICATIONS: There are approximately 2000 Radiation Oncology clinics in the USA. If 1/3 of them purchase the verification phantom at $3500 and the software at $2500 this yields a potential total revenue of $4,000,000. If the system is used for monthly QA of an IMRT dynamic MLC system and if the monthly testing includes the use of 2 Gel inserts at $125 each and an additional $200 for the MR dosimetry, this leads to an annual revenue of $5400 per institution. If 25% of the institutions (the larger university centers) follow this course of action this leads to an additional annual revenue of $2,700,000 per year.

患者剂量升级的使用3D RTP和IMRT正在增加。这些高科技方法的增长和普遍接受的主要绊脚石是缺乏可用的方法来验证计划的剂量是否正确地交付给患者。 MGS Research Incorporated已经开发了组织等效的凝胶（R）凝胶，可以记录治疗剂量时电离辐射的完整3D剂量分布的永久图像。可以使用磁共振成像（MRI）以高空间精度和精度来测量爆炸凝胶中的剂量分布。 MGS研究验证了Bang Gel剂量测定法对放射疗法的潜在效用后，旨在根据使用Bang Gel Phantoms和MRI的使用，与Stony Brook的SUNY与Stony Brook的Suny合作创建了完全自动化的3D形成型RTP和IMRT验证系统。我们的系统将是用于此目的的唯一工具，因此我们预计需求量很大。该项目的长期目标是提供独特的产品，包括1）DICOM-RT兼容软件模块，能够从受辐照的爆炸性爆炸凝胶幻象的MRI扫描中创建3D剂量数据集，并与治疗计划数据（I和II阶段）相关联（2阶段），2），2），一系列特殊设计的bang Gel gel geel and Mri-II和MRI-II和MRI-SENISSISSSISISSSISSISSSISISSSISSISSSISSISSSISSSISSSISSSISSSISSSISSSISSSISISSSSINISSSSISSISSSSISISSSSINISS（使用BANG GEL DOSIMETER（III阶段）为客户提供的凝胶分析服务。拟议的商业应用：美国大约有2000个辐射肿瘤学诊所。 如果他们中的1/3以3500美元的价格购买验证幻影，而该软件为2500美元，则可能会产生4,000,000美元的潜在总收入。如果该系统用于IMRT动态MLC系统的每月质量检查，并且每月测试包括使用2个凝胶插入物，则每份$ 125，MR Dosimetry的额外使用$ 200，这将导致每个机构的年收入为5400美元。如果25％的机构（较大的大学中心）遵循这一行动方案，则每年的年收入额外为2,700,000美元。