RENOVATION OF ANIMAL WING FOR BSL-3 CAPABILITY

为 BSL-3 能力改造动物翅膀

• 批准号: 2696126
• 负责人: DALLAS Melvin HYDE
• 金额: $ 62.11万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 2002-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2696126
• 关键词: animal care; animal colony; biomedical equipment purchase; biomedical resource; building /facility design /renovation; germ free condition

The California Regional Primate Research Center (CRPRC) does not currently have adequate facilities to conduct Biosafety Level 3 (BSL-3) research, due to lack of BSL-3 animal housing space. Funds are requested to convert existing animal housing space to BSL-3 containment space. The CRPRC has a new 4,000 ASF animal wing consisting of ten animal rooms, and necropsy and investigator workspace. One-half of this vivarium (2.000 ASF) was designed to be efficiently retrofitted to BSL-3 animal housing with the addition of HEPA filtered room exhaust, a large 84"L X 48"W X 84"H autoclave, and 21 stainless steel four-pack cage racks to be used in BSL-3 animal housing. Each BSL-3 animal room will be under negative airflow with an anteroom and an exit into a dirty corridor. The dirty corridor will have access to the pass-thru autoclave and a pass-thru shower facility for personnel to exit the biocontainment space. The proposed renovations will allow the CRPRC to accommodate critical research with BSL-3 agents in a containment facility that provides optimal occupational safety and also provides the animals with opportunities for social enrichment. This facility is necessary to provide animal research space to accommodate expanding research programs in tuberculosis, Borna Disease virus, as well as new viral vectors in gene therapy research. In addition, the new BSL-3 space will allow for expansion of CRPRC's retroviral research program into further research with recombinant HIV, SIV and viral co-infections with SIV infected animals.

加州地区灵长类研究中心 (CRPRC) 目前没有 拥有足够的设施进行生物安全 3 级 (BSL-3) 研究， 由于缺乏 BSL-3 动物饲养空间。要求资金转换 将现有动物饲养空间改为 BSL-3 收容空间。 CRPRC 拥有一个新的 4,000 只 ASF 动物翼，由 10 个动物室组成， 以及尸检和调查人员工作区。该动物园的一半（2.000 ASF）旨在有效改造 BSL-3 动物房屋 加上 HEPA 过滤室排气，一个 84 英寸长 X 48 英寸宽 X 的大尺寸 84"H 高压灭菌器和 21 个不锈钢四件套笼架，用于 BSL-3 动物房。每个 BSL-3 动物房均处于负压状态 设有前厅和通往肮脏走廊的出口的气流。肮脏的 走廊将可通往直通高压灭菌器和直通 供人员离开生物防护空间的淋浴设施。 拟议的翻修将使 CRPRC 能够容纳关键的 在收容设施中使用 BSL-3 特工进行研究，提供最佳的 职业安全，也为动物提供了机会 社会丰富化。该设施对于提供动物研究是必要的 容纳扩大的结核病研究项目的空间，博尔纳 疾病病毒，以及基因治疗研究中的新病毒载体。在 此外，新的 BSL-3 空间将允许 CRPRC 的扩展 逆转录病毒研究计划进一步研究重组艾滋病毒， SIV 和病毒同时感染 SIV 感染动物。