KUMC LABORATORY ANIMAL RESOURCES IMPROVEMENTS

KUMC 实验室动物资源的改善

• 批准号: 6755553
• 负责人: DAVID M PINSON
• 金额: $ 67.23万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2005-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6755553
• 关键词: Primates; Rodentias; animal care; animal colony; biomedical equipment purchase; biomedical facility; building /facility design /renovation

DESCRIPTION (provided by applicant): The University of Kansas Medical Center's Laboratory Animal Resources is seeking funds to accomplish needed repairs on the Research Support Facility in order to comply with recommendations in the Guide for the Care and Use of Laboratory Animals, to advance the diagnostic and surgical components of the animal care and use program, and to enhance animal caging. The rationale for this proposal is based on long standing infrastructure deficiencies, aging equipment that is no longer supported by manufacturers, the disease outbreak potential in expanding receipt and dispersion of transgenic animals, and chronic primate caging shortages. Our specific aims include the following: 1) replace an original water heater that has insufficient function to meet hot water demands of the building; 2) purchase and install sensors needed to establish centralized HVAC monitoring; 3) establish a molecular diagnostic laboratory to provide rapid viral screening for incoming and outgoing genetically modified rodents; 4) purchase needed anesthesia equipment and surgery tables to replacing aging machines that are no longer supported and to provide to investigators rodent anesthesia machines; 5) purchase primate racks to increase our reserves in the face of expanding primate populations; and 6) to begin a transition to forced air ventilated racks. The proposed specific aims will provide long term improvement and will advance the animal care and use program's 2001 Strategic Plan, which details many of these issues. Accomplishment of Aims #1 and #2 should bring us further into compliance with the Guide for the Care and Use of Laboratory Animals. Specific Aims #3 and #4 will enhance the overall animal health and surgical programs of department. Specific aims #5 and #6 will provide additional and more efficient caging to meet shortages and to increase the efficiency of existing technical staff. The current budget constraints on KU Medical Center do not permit funding these major improvements that are critically needed to maintain an adequate program of animal care and use at this institution.

描述（由申请人提供）： 堪萨斯大学医学中心的实验室动物资源正在寻求资金来完成研究支持机构所需的维修，以便遵守《实验动物的护理和使用指南》中的建议，以促进动物护理和使用计划的诊断和外科手术组成部分，并增强动物笼。该提案的基本原理是基于长期存在的基础设施缺陷，不再得到制造商支持的老化设备，疾病爆发的爆发潜力扩大了转基因动物的接收和分散以及慢性灵长类动物的短缺。我们的具体目的包括以下内容： 1）更换一个原始的热水器，该热水器的功能不足以满足建筑物的热水需求； 2）建立集中式HVAC监视所需的购买和安装传感器； 3）建立一个分子诊断实验室，以提供快速的病毒筛查，以进行传入和传出的转基因啮齿动物； 4）购买需要麻醉设备和手术表来代替不再支持的老化机器，并向调查人员提供啮齿动物麻醉机； 5）购买灵长类机架以面对扩大灵长类动物种群的增加，以增加我们的储量； 6）开始过渡到强制空气通风架。拟议的特定目标将提供长期的改进，并将推进动物护理和使用计划的2001年战略计划，该计划详细介绍了其中许多问题。目标＃1和＃2的实现应该使我们进一步遵守《实验动物的护理和使用指南》。具体目标＃3和＃4将增强部门的整体动物健康和外科计划。具体目标＃5和＃6将提供额外，更有效的笼子，以满足短缺并提高现有技术人员的效率。当前对KU医疗中心的预算限制不允许为维持该机构的动物护理和使用计划的重要改进提供资金。