IN VIVO MEASUREMENT OF 17O W/ SURFACE COIL STEAM DECOUPLING

带表面盘管蒸汽去耦的 17O 体内测量

• 批准号: 6121032
• 负责人: SRIDHAR R CHARAGUNDLA
• 金额: $ 1.35万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 1999-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6121032
• 关键词: biomedical resource; magnetic resonance imaging; nuclear magnetic resonance spectroscopy; technology /technique

The standard method of 17O decoupling uses a spin-echo sequence and therefore requires a volume coil for proper implementation. We have developed a pulse sequence that allows 17O decoupling during a proton stimulated echo (STEAM) sequence. This allows use of a double-tuned surface coil for 17O quantification. Use of a surface coil carries several advantages over the use of a volume coil, including improved signal-to-noise ratios and suitability for studying small volumes of tissue. We have successfully detected natural-abundance 17O in animals using this sequence. Further improvements to the sequence are underway, including adaptation for multi-voxel spectroscopy and imaging.

17o解耦的标准方法使用自旋回波序列 因此，需要一个卷线圈才能正确实施。 我们 已经开发了一个脉冲序列，该序列允许在 质子刺激回声（蒸汽）序列。 这允许使用 双调节表面线圈，用于17O定量。 使用表面 线圈在使用音量线圈上具有多个优势， 包括提高的信噪比和研究的适用性 少量的组织。 我们已经成功检测到 使用此序列的动物中的自然丰富性17o。 更远 序列的改进正在进行中，包括适应 多素谱和成像。