BRAIN:T1_ DISPERSION IMAGING OF 17O IN VIVO

BRAIN:T1_ 17O 体内色散成像

• 批准号: 6495444
• 负责人: SRIDHAR R CHARAGUNDLA
• 金额: $ 22.55万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6495444
• 关键词: bioimaging /biomedical imaging; biomedical resource; magnetic resonance imaging; nuclear magnetic resonance spectroscopy; technology /technique

We are developing a novel technique for indirect 17O detection by combining 1H spin-locking and 17O decoupling into an interleaved spin-locking/decoupling sequence. This sequence appears to reproduce simultaneous irradiation of the nuclei, while using a single, double-tuned coil. Preliminary experiments indicate an improvement in signal-to-noise ratios of proton spectra (as compared to 17O-decoupled 1H spectra) and a correspondingly greater accuracy in the detection of 17O. This sequence suggests itself for use as a preparatory pulse cluster in fast imaging sequences and may even prove useful in the transfer of heteronuclear polarization in scalar-coupled systems modulated by chemical exchange. We have continued work on characterization of this sequence; in particular, we are empirically investigating optimal pulse timing parameters and theoretically modelling the sequence. Furthermore, we are studying the sensitivity and specificity of the sequence to the presence of 17 O by measuring the effects of gadolinium-doping on proton signal enhancement.

我们正在开发一种新型技术，用于间接17O检测 将1H自旋锁定和17o脱钩成交错 自旋锁定/解耦序列。 这个序列似乎繁殖 同时使用单个的核的照射， 双调节线圈。 初步实验表明有所改善 质子光谱的信噪比（与17o折叠相比 1H光谱），在检测中相应的精度更高 17o。 这个序列建议将自己用作预备脉冲 聚集在快速成像序列中，甚至可能在 标量耦合系统中异核极化的转移 通过化学交换调节。 我们一直在继续工作 该序列的表征；特别是，我们在经验上是 研究最佳脉冲正时参数和理论上 建模序列。 此外，我们正在研究灵敏度 通过测量，序列对17 O的存在的特异性 兴奋剂掺杂对质子信号增强的影响。