BRAIN: IN VIVO MEASUREMENT OF 17O W/ SURFACE COIL STEAM DECOUPLING

大脑：17O 的体内测量，带表面盘管蒸汽去耦

• 批准号: 6349300
• 负责人: SRIDHAR R CHARAGUNDLA
• 金额: $ 2.8万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6349300
• 关键词: aging; arthritis; bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical resource; connective tissue; female; human subject; magnetic resonance imaging; male; proteins; radiology; technology /technique

Osteoarthritis is a degenerative disease of cartilage, affecting 40 million Americans and more than 80% of people age 55 and over. It is characterized by degradation of the cartilage matrix with symptoms of joint stiffness and swelling, bony enlargements, and pain. Cartilage consists mainly of an extra-cellular matrix (ECM) of type II collagen and proteoglycans, in an intertwining array. Water content in cartilage ranges from 70% to 80%. Approximately 60% of the dry weight of cartilage is collagen, with the remainder mostly being the proteoglycans (PG). It is now known that degradation of cartilage in an early osteoarthritic condition primarily involves the loss of the PG. We have imaged a healthy human knee using saline/agarose phantoms whose 23Na relaxation times have been normalized to cartilage. This allows the creation of a calibration curve to fit pixel intensities of the cartilage to in an effort to quantitate the signal. This sodium signal directly corresponds to the PG content in the cartilage, thereby providing a method to monitor tissue integrity. We are investigating the use of surface coils, a birdcage coil and a transmit only birdcage coil with surface receive coils. We are currently underway in a plan to determine sodium concentrations in several healthy human volunteers as well as subjects grouped by age.

骨关节炎是软骨的退化性疾病，影响 4000万美国人和55岁及以上的人中有80％以上。 它 其特征是软骨矩阵降解和症状 关节刚度和肿胀，骨扩大和疼痛。 软骨主要由II型的细胞外基质（ECM）组成 胶原蛋白和蛋白聚糖，在一个相互交织的阵列中。 水含量 软骨的范围从70％到80％。 大约60％的干 软骨的重量是胶原蛋白，其余的主要是 蛋白聚糖（PG）。 现在知道软骨的降解 早期的骨关节炎条件主要涉及 pg。 我们已经使用盐水/琼脂糖成像了健康的人膝盖 23na松弛时间已归一化的幻影 软骨。 这允许创建校准曲线适合 软骨的像素强度是为了定量 信号。 该钠信号直接对应于PG含量 软骨，从而提供了一种监测组织完整性的方法。 我们正在研究表面线圈的使用，鸟笼线圈和一个 仅传输带有表面的鸟笼线圈接收线圈。 我们是 目前正在计划确定钠浓度的计划 几名健康的人类志愿者以及按年龄分组的受试者。