DEVELOPMENT OF HIGH & LOW RISK PRIMATES

高发展

• 批准号: 6219681
• 负责人: GENE P. SACKETT
• 金额: $ 13.45万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6219681
• 关键词: Mammalia; behavioral /social science research tag; cognition; congenital disorders; growth /development; infant mortality; low birth weight infant human; model design /development; nervous system; psychology

In this project we are studying growth and the neural, biochemical, and behavioral development of nursery-reared monkeys that are at low and high risk for developmental abnormalities. High-risk "infant save" subjects have low birth weight, were born prematurely, are sick, maternally rejected and injured, or genetically abnormal animals born to members of the WaRPRC breeding colony. Low-risk subjects are healthy infants whose mothers cannot care for them because of illness, death, or assignment to experimental projects. We study these animals to (1) document the development of high-risk monkeys, (2) provide normative information for developmental experiments requiring large sample control data, and (3) develop and expand primate models of human high-risk conditions and potential models of human genetic disorders affecting developmental processes. Measures taken on these moneys range from data on body weight and skeletal and brain growth, through assessments of imm une and ho rmone status, to studies of reflexive, perceptual, learned, and social behavior spanning the period of birth through infancy. This work also provides research training for 25-30 undergraduate and 5-10 graduate students each year, and provides the material for several PhD and nursing degree candidates in most years. During the past year we continued data collection on high- and low-risk infants, we began development of a procedure for studying the stress hormone, cortisol, using saliva rather than requiring capture for blood draws, and we followed development of three monkeys born with congenital brain abnormalities. We are assessing the genetic status of the latter three animals in an attempt to locate the responsible genome mutations through perigree analyses. We believe this work may identify an important primate model of abnormal fetal brain development. Supported by NIH grants RR00166 and HD08633. Ha, J.C., Nosbisch, C., Abkowitz, J.L., Conrad, S.H., Mottet, N.K., Ruppenthal, G.C., Robinette, R., Sackett, G.P., and Unadkat. J.D. Fetal, infant, and maternal toxicity of zidovudine (azidothymidine) administered throughout pregnancy in Macaca nemestrina. J. AIDS Hum Retrovirol 18:27-38, 1998. Heath-Lange, S., Ha, J.C., and Sackett, G.P. Behavioral measurement of temperament in male nursery-raised infant macaques and baboons. Am. J. Primatol. 47:43-50, 1999. Sackett, G.P., Novak, M.F.S.X., and Kroeker, R. Early experience effects on adaptive behavior theory revisited. Ment. Retard. Devel. Disabil. Rev. 5 1-11, 1999.

在这个项目中，我们正在研究增长和神经， 生化和行为发展苗圃的猴子 发育异常的低风险和高风险。 高风险 “婴儿拯救”受试者的出生体重低，过早出生 生病，母亲拒绝和受伤或遗传异常 Warprc繁殖殖民地成员出生的动物。 低风险 受试者是健康的婴儿，母亲无法照顾他们 由于疾病，死亡或对实验项目的分配。 我们 研究这些动物以（1）记录高风险的发展 猴子，（2）为发展提供规范信息 需要大型样品控制数据的实验，（3）发展和 扩大人类高风险条件和潜力的灵长类动物模型 影响发育过程的人类遗传疾病的模型。 对这些款项采取的措施范围从体重的数据和 通过评估IMM和HO RMONE的骨骼和大脑生长 身份，反思性，感知，学识关系和社会的研究 通过婴儿期出生时期的行为。 这项工作也是如此 为25-30本大学和5-10名研究生提供研究培训 每年的学生，并提供多个博士学位的材料 大多数年份的护理学位候选人。 在过去的一年中 关于高风险婴儿和低风险婴儿的持续数据收集，我们开始 开发研究应力激素皮质醇的程序， 使用唾液而不是需要抽血的捕获，我们 随后开发了三只猴子出生的先天性大脑 异常。 我们正在评估后者的遗传状况 三只动物试图找到负责任的基因组突变 通过Perigree分析。 我们相信这项工作可能会确定 胎儿脑发育异常的重要灵长类动物模型。 由NIH赠款RR00166和HD08633支持。 Ha，J.C.，Nosbisch，C.， Abkowitz，J.L.，Conrad，S.H.，N.K. Mottet，Ruppenthal，G.C。， Robinette，R.，Sackett，G.P。和Unadkat。 J.D.胎儿，婴儿， Zidovudine（偶氮苷）的孕产妇毒性 整个怀孕的Macaca Nemestrina。 J. AIDS HUM RETOVIROL 18：27-38，1998。Heath-Lange，S.，HA，J.C。和G.P. Sackett 男性托儿所抚养婴儿的气质的行为测量 猕猴和狒狒。 是。 J. Primatol。 47：43-50，1999。Sackett， G.P.，Novak，M.F.S.X。和Kroeker，R。 自适应行为理论重新审视。 精神。 减速。 开发。 disabil。 Rev. 5 1-11，1999。