SLEEP AND ABNORMAL BEHAVIOR

睡眠和异常行为

• 批准号: 7349323
• 负责人: GENE P. SACKETT
• 金额: $ 13.2万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349323
• 关键词: SLEEP; ABNORMAL; BEHAVIOR; SLEEP; ABNORMAL; BEHAVIOR

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Captive macaque monkeys housed for long periods of time in single cages often develop behaviors that are atypical for their species and may indicate disturbance and abnormality. A common atypical behavior is stereotyped repetitive locomotion. A less common (3-5%) behavior type is potential or actual self-injurious behaviors (SIBs). SIBs include actions such as self-biting, chronic hair pulling or grooming, and head banging. SIB may occur daily or much less frequently in different animals, and is often resistant to treatment. This study tested the hypothesis that SIB is correlated with disturbed sleep. Eight pairs of aged adult monkeys (m. fascicularis) included one animal that exhibited daytime SIB and one not seen to exhibit SIB during daytime hours. Movement during night (room dark) hours was detected by an infrared video system, which activated computer digital video recording for the duration of movement. Amount of activity was automatically recorded and video scenes were scored by observers for the type of activity. Overall, SIB monkeys had more night wake periods for longer durations than controls. SIB monkeys often exhibited their SIB behavior during active periods. Of most importance for identifying animals with SIB, one control monkey, never observed to self-bite, exhibited the most self-biting during the night. Sleep observations are currently being followed in infant and juvenile monkeys to determine relationships between night period activity and daytime behavior and cortisol.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。长时间容纳在单个笼子里的圈养猕猴通常会发展出对其物种非典型的行为，并可能表明干扰和异常。常见的非典型行为是刻板印象的重复运动。较不常见的行为类型（3-5％）是潜在的或实际的自我伤害行为（SIBS）。 SIB包括自我咬人，慢性头发拉或修饰等动作以及头部敲打。 SIB可能每天发生或在不同动物中发生的频率较低，并且通常对治疗有抵抗力。这项研究检验了SIB与睡眠障碍相关的假设。八对年迈的成年猴子（M。casticularis）包括一只展示白天同胞的动物，在白天没有看到一只动物。黑夜（房间黑暗）的移动是通过红外视频系统检测到的，该视频系统在移动期间激活了计算机数字视频录制。自动记录活动量，并由观察者评分视频场景的活动类型。总体而言，SIB猴子的夜间唤醒时间比对照更长。 SIB猴子经常在活动期间表现出其SIB行为。对于用SIB识别动物的最重要性，一只控制猴子从未被观察到自咬，在夜间表现出最自我挑剔的表现。目前，婴儿和少年猴子正在遵循睡眠观察，以确定夜间活动与白天行为与皮质醇之间的关系。