A PRIMATE MODEL OF GUT, IMMUNE, AND CNS RESPONSE TO CHILDHOOD VACCINES

儿童疫苗的肠道、免疫和中枢神经系统反应的灵长类动物模型

• 批准号: 8357602
• 负责人: GENE P. SACKETT
• 金额: $ 15.66万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357602
• 关键词: Affect; Animals; Autistic Disorder; Child; Childhood; Cognitive; Colitis; Development; Diagnosis; Funding; Giant Cells; Grant; Immune; Immunologics; Inflammation; Modeling; National Center for Research Resources; Neurodevelopmental Deficit; Primates; Principal Investigator; Reflex action; Regimen; Research; Research Infrastructure; Resources; Source; Symptoms; Testing; Thimerosal; Toxic effect; United States; United States National Institutes of Health; Vaccinated; Vaccines; cost; developmental disease; gastrointestinal; lymphoid hyperplasia; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Diagnoses of childhood developmental disorders involving autism-spectrum symptoms are increasing, estimated to affect 1 in 100 children in the United States. Childhood vaccines have been hypothesized to be contributory factors to this increase. The childhood vaccine regimen has an experimentally unstudied potential for cumulative and synergistic toxicities and possible immunologic interference to normal development. A prior study developed a primate model to assess neurodevelopmental consequences of the 1994-1999 pediatric thimerosal vaccine regimen (1994-1999). Significant neurodevelopmental deficits were evident for vaccinated animals in survival reflexes and standardized cognitive tests, and exposed animals developed gastrointestinal inflammation associated with focal transmural colitis, lymphoid hyperplasia, and syncytia.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 涉及自闭症谱系症状的儿童发育障碍的诊断正在增加，估计在美国有100名儿童中有1个。 已经假设儿童疫苗是增加这种增加的因素。 儿童疫苗方案具有实验未研究的潜在潜在的累积和协同毒性的潜力，并可能对正常发育的免疫干扰。 一项先前的研究开发了一种灵长类动物模型，以评估1994 - 1999年儿科硫胺疫苗方案的神经发育后果（1994-1999）。在存活反射和标准化的认知测试中，疫苗接种动物的明显神经发育缺陷显而易见，而暴露的动物发生了与局灶性透壁结肠炎，淋巴样增生和综合症相关的胃肠道炎症。