A PRIMATE MODEL OF GUT, IMMUNE, AND CNS RESPONSE TO CHILDHOOD VACCINES

儿童疫苗的肠道、免疫和中枢神经系统反应的灵长类动物模型

• 批准号: 7958873
• 负责人: GENE P. SACKETT
• 金额: $ 31.52万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958873
• 关键词: Animals; Brain; Centers for Disease Control and Prevention (U.S.); Chemistry; Childhood; Cognition; Combined Vaccines; Computer Retrieval of Information on Scientific Projects Database; Crohn' s disease; Development; Exhibits; Funding; Grant; Human; Immune; Impairment; Infant; Infant Behavior; Inflammation; Institution; Life; Macaca mulatta; Modeling; Monkeys; Mumps; Outcome; Pilot Projects; Primates; Research; Research Personnel; Resources; Rubella virus vaccine; Source; Structure; Treatment Protocols; United States National Institutes of Health; Vaccinated; Vaccines; Virus; behavioral impairment; gastrointestinal; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A pilot project was performed studying infant rhesus macaques who received the complete childhood vaccine regimen recommended by the Center for Disease Control (CDC) through the 1990s. The results demonstrated that vaccinated monkeys displayed behavioral impairments and exhibited gastrointestinal inflammation with features similar to Crohn's disease. This followup research will also study rhesus macaque infants to determine whether these adverse outcomes are associated with human mumps-measels-rubella vaccines that only contain preservatives, that contain live-viruses, or contain a combination of both. The first study aim is to more fully examine the developmental effects of these vaccine combinations on infant behavior, cognition, and aspects of brain structure and chemistry. The second aim is to determine if gastrointestinal inflammation is again related to vaccine condition, and if so whether afflicted animals also display developmental impairments.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 一项试点项目对幼年恒河猴进行了研究，这些恒河猴在 20 世纪 90 年代接受了美国疾病控制中心 (CDC) 推荐的完整儿童疫苗方案。 结果表明，接种疫苗的猴子表现出行为障碍，并表现出胃肠道炎症，其特征类似于克罗恩病。 这项后续研究还将研究恒河猴婴儿，以确定这些不良后果是否与仅含有防腐剂、含有活病毒或两者组合的人类腮腺炎-斑疹伤寒-风疹疫苗有关。 第一个研究目的是更全面地研究这些疫苗组合对婴儿行为、认知以及大脑结构和化学方面的发育影响。 第二个目标是确定胃肠道炎症是否再次与疫苗状况有关，如果是，受影响的动物是否也表现出发育障碍。