A PRIMATE MODEL OF GUT, IMMUNE, AND CNS RESPONSE TO CHILDHOOD VACCINES

儿童疫苗的肠道、免疫和中枢神经系统反应的灵长类动物模型

• 批准号: 7958873
• 负责人: GENE P. SACKETT
• 金额: $ 31.52万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958873
• 关键词: Animals; Brain; Centers for Disease Control and Prevention (U.S.); Chemistry; Childhood; Cognition; Combined Vaccines; Computer Retrieval of Information on Scientific Projects Database; Crohn' s disease; Development; Exhibits; Funding; Grant; Human; Immune; Impairment; Infant; Infant Behavior; Inflammation; Institution; Life; Macaca mulatta; Modeling; Monkeys; Mumps; Outcome; Pilot Projects; Primates; Research; Research Personnel; Resources; Rubella virus vaccine; Source; Structure; Treatment Protocols; United States National Institutes of Health; Vaccinated; Vaccines; Virus; behavioral impairment; gastrointestinal; response; Animals; Brain; Centers for Disease Control and Prevention (U.S.); Chemistry; Childhood; Cognition; Combined Vaccines; Computer Retrieval of Information on Scientific Projects Database; Crohn' s disease; Development; Exhibits; Funding; Grant; Human; Immune; Impairment; Infant; Infant Behavior; Inflammation; Institution; Life; Macaca mulatta; Modeling; Monkeys; Mumps; Outcome; Pilot Projects; Primates; Research; Research Personnel; Resources; Rubella virus vaccine; Source; Structure; Treatment Protocols; United States National Institutes of Health; Vaccinated; Vaccines; Virus; behavioral impairment; gastrointestinal; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A pilot project was performed studying infant rhesus macaques who received the complete childhood vaccine regimen recommended by the Center for Disease Control (CDC) through the 1990s. The results demonstrated that vaccinated monkeys displayed behavioral impairments and exhibited gastrointestinal inflammation with features similar to Crohn's disease. This followup research will also study rhesus macaque infants to determine whether these adverse outcomes are associated with human mumps-measels-rubella vaccines that only contain preservatives, that contain live-viruses, or contain a combination of both. The first study aim is to more fully examine the developmental effects of these vaccine combinations on infant behavior, cognition, and aspects of brain structure and chemistry. The second aim is to determine if gastrointestinal inflammation is again related to vaccine condition, and if so whether afflicted animals also display developmental impairments.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 进行了一个试点项目，研究了婴儿恒河猕猴，该猕猴接受了1990年代疾病控制中心（CDC）推荐的完整儿童疫苗方案。 结果表明，接种疫苗的猴子表现出行为障碍，并表现出胃肠道炎症，其特征与克罗恩病相似。 这项后续研究还将研究恒河猕猴的婴儿，以确定这些不良结果是否与仅包含含有活性病毒的防腐剂的人类amumps-measels-rubella疫苗有关，或者两者都包含两者的组合。 第一个研究的目的是更充分地研究这些疫苗组合对婴儿行为，认知以及大脑结构和化学方面的发育效果。 第二个目的是确定胃肠道炎症是否再次与疫苗状况有关，如果是这样的话，是否遭受了折磨的动物也表现出发育障碍。