Prediction of CVD Risk in Veterans

退伍军人心血管疾病风险预测

• 批准号: 9220725
• 负责人: Kelly Cho
• 金额: --
• 依托单位: VETERANS HEALTH ADMINISTRATION
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9220725
• 关键词: Address; Adult; Age; Algorithms; Ambulatory Care; Assessment tool; Atherosclerosis; Atrial Fibrillation; Blood Platelets; Blood Pressure; Calibration; Cardiovascular Diseases; Cardiovascular system; Cessation of life; Cholesterol; Communities; Coronary artery; Coronary heart disease; Data; Development; Diabetes Mellitus; Diagnosis; Discrimination; Equation; Evaluation; Event; Formulation; Framingham Heart Study; Future; Glomerular Filtration Rate; Glycosylated hemoglobin A; Guidelines; Health; Health care facility; Health system; Heart failure; High Density Lipoprotein Cholesterol; High Prevalence; Lead; Lipids; Malignant Neoplasms; Mental Health; Mental disorders; Modeling; Morbidity - disease rate; Myocardial Infarction; Obesity; Outcome; Outpatients; Patient-Centered Care; Peripheral Vascular Diseases; Pharmaceutical Preparations; Population Group; Preventive service; Preventive therapy; Publishing; Race; Recording of previous events; Recurrence; Recurrent disease; Renal dialysis; Research; Resources; Risk; Risk Assessment; Risk Behaviors; Risk Estimate; Risk Factors; Role; Smoking; Smoking Behavior; Stroke; Update; Veterans; Women' s Health; base; burden of illness; cardiovascular disorder risk; cardiovascular health; cigarette smoking; clinical care; clinical practice; cost; diabetes mellitus therapy; evidence base; experience; high risk; interest; mortality; personalized medicine; physical inactivity; pressure; public health relevance; sex; smoking prevalence

DESCRIPTION (provided by applicant): We propose to assess the role of cardiovascular disease (CVD) risk estimation in veterans without cancer or other major illnesses and compare the utility of using US national guideline estimates from ATP4 versus VA-specific formulations developed from VISN 1 and VISN 7. The core variables that will be used include traditional risk factors such age, sex, race, blood pressure, smoking, cholesterol, HDL cholesterol and diabetes status. In addition, we propose to identify the best ways to assess CVD risk in veterans with diabetes mellitus and in veterans who have already experienced a CVD event. We will evaluate the precision and accuracy of the ATP4 estimating equations in the VA and separately develop CVD risk equations using ATP4 variables to evaluate the best approach to estimate CVD risk in veterans. This critical evaluation of the risk of CVD in veterans is aimed to provide effective and convenient risk assessment tools - that in the future could be incorporated into clinical care for outpatient veterans and has the potential to guide CVD preventive therapy within the VA so that resources can be aligned to intervene appropriately with cardiovascular preventive services in veterans at high risk for developing a future CVD event. This proposal has direct relevance to the health risks of risky behavior (cigarette smoking), women's health, and patient-centered care.

描述（由申请人提供）： 我们建议评估心血管疾病 (CVD) 风险评估在没有癌症或其他重大疾病的退伍军人中的作用，并比较使用 ATP4 的美国国家指南评估与从 VISN 1 和 VISN 7 开发的 VA 特定公式的效用。 核心变量将使用的风险因素包括年龄、性别、种族、血压、吸烟、胆固醇、高密度脂蛋白胆固醇和糖尿病状况等传统风险因素。此外，我们建议确定评估患有糖尿病的退伍军人和已经经历过 CVD 事件的退伍军人的 CVD 风险的最佳方法。我们将评估 VA 中 ATP4 估计方程的精度和准确性，并使用 ATP4 变量单独开发 CVD 风险方程，以评估估计退伍军人 CVD 风险的最佳方法。这项对退伍军人心血管疾病风险的严格评估旨在提供有效、方便的风险评估工具——未来可以将其纳入门诊退伍军人的临床护理中，并已 在退伍军人管理局内指导心血管疾病预防治疗的潜力，以便可以调整资源，对未来发生心血管疾病事件高风险的退伍军人进行心血管预防服务的适当干预。该提案与危险行为（吸烟）的健康风险、妇女健康和以患者为中心的护理直接相关。