NEURAL ACTIVATION IN ADOLESCENT ALCOHOL ABUSERS

青少年酗酒者的神经激活

• 批准号: 6051974
• 负责人: SUSAN F TAPERT
• 金额: $ 9.75万
• 依托单位: VETERANS MEDICAL RESEARCH FDN/SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-01 至 2002-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6051974
• 关键词: adolescence (12-20); alcoholism /alcohol abuse; bioimaging /biomedical imaging; biomedical equipment development; brain electrical activity; brain mapping; cingulate gyrus; clinical research; cognition; craving; cues; disease /disorder etiology; disease /disorder onset; drug withdrawal; functional ability; functional magnetic resonance imaging; human subject; neural information processing; parietal lobe /cortex; prefrontal lobe /cortex; prognosis; psychological tests; substance abuse epidemiology

The goal of this exploratory/developmental project is to investigate neurobiological mechanisms of adolescent alcohol dependence utilizing and refining functional magnetic resonance imaging (fMRI) procedures and protocol. Alcohol involvement is prevalent during adolescence, but little is known regarding its influence on cognition. Our previous studies suggested that severity of alcohol withdrawal symptoms predicts neuropsychological impairments in adolescents. fMRI is a noninvasive and safe technique for examining brain functioning. However, several challenges remain for its implementation with alcohol dependent adolescents, including minimizing motion artifact, maximizing participant compliance and comfort, and characterizing normal adolescent brain activation patterns. This project seeks to characterize neural consequences of heavy drinking during adolescence by evaluating hemodynamic changes in brain regions of alcohol dependent teens and controls during performance of cognitive challenge and alcohol cue exposure tasks. In addition, we hope to refine fMRI protocol and procedures for use with alcohol dependent adolescents. Our specific aims are: 1) to investigate activation patterns in brain regions that may be influenced by adolescent alcohol dependence and withdrawal, 2) to examine brain activation patterns associated with craving and processing alcohol-related information in teens with varied alcohol involvement histories, and 3) to optimize FMRI procedures for use with alcohol dependent adolescents. To achieve these aims, 20 alcohol dependent teens and 20 demographically matched controls will be presented with tasks designed to activate brain regions potentially involved in adolescent alcohol dependence in the fMRI environment. We hypothesize that alcohol dependent adolescents and controls will differ in brain activation patterns, both as a consequence of excessive drinking as well as in response to alcohol cues. Results will help characterize brain regions affected by heavy drinking and involved in craving states among adolescents. Resulting protocol refinement and pilot data will be used in developing a broader research program investigating neural aspects of protracted alcohol use, alcohol-related information processing, craving, etiological factors of early drinking, and predictors of future alcohol problems and problem recovery. The longer-term goal of this program of research is to develop targeted therapies for adolescents with alcohol use disorders.

这个探索/开发项目的目标是 研究青少年酒精依赖的神经生物学机制 利用和完善功能磁共振成像 (fMRI) 程序 和协议。青少年时期酗酒很常见，但很少 众所周知它对认知的影响。我们之前的研究表明 酒精戒断症状的严重程度预示着神经心理学 青少年的损伤。 fMRI 是一种无创且安全的技术 检查大脑功能。然而，其仍面临一些挑战 对酒精依赖青少年实施，包括尽量减少运动 工件，最大限度地提高参与者的依从性和舒适度，并表征 正常的青少年大脑激活模式。该项目旨在 描述青春期酗酒的神经后果 评估酒精依赖青少年大脑区域的血流动力学变化 认知挑战和酒精暗示暴露期间的控制 任务。此外，我们希望完善fMRI协议和使用程序 与酒精依赖的青少年。我们的具体目标是：1）调查 可能受青少年影响的大脑区域的激活模式 酒精依赖和戒断，2) 检查大脑激活模式 与青少年渴望和处理酒精相关信息有关 具有不同的酒精参与史，以及 3) 优化 FMRI 程序 用于酒精依赖的青少年。为了实现这些目标，20 种酒精 将提供受抚养青少年和 20 个人口统计匹配的对照 旨在激活青少年可能涉及的大脑区域的任务 fMRI 环境中的酒精依赖。我们假设酒精 依赖青少年和对照组的大脑激活模式会有所不同， 既是过量饮酒的结果，也是对酒精的反应 提示。结果将有助于描述受酗酒影响的大脑区域 并卷入青少年的渴望状态。结果协议 细化和试点数据将用于开展更广泛的研究 研究长期饮酒的神经方面的计划， 与酒精相关的信息处理、渴望、早期的病因因素 饮酒，以及未来酒精问题和问题恢复的预测因素。这 该研究计划的长期目标是开发靶向疗法 对于患有酒精使用障碍的青少年。