COLLABORATIVE PROGRAM IN BPD

BPD 合作项目

• 批准号: 6184292
• 负责人: JACQUELINE Jones COALSON
• 金额: $ 196.41万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-07-20 至 2004-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6184292
• 关键词: animal breeding; animal colony; baboons; bronchopulmonary dysplasia; cooperative study; data management; disease /disorder model; neonatal intensive care; pathologic process; premature infant animal; respiratory distress syndrome of newborn; tissue resource /registry

The overall goal of this cooperative research program is to develop a multi- institutional research effort to address the mechanisms of postnatal lung pathobiology that lead to chronic lung disease and to provide a unique resource center of prematurely delivered baboons with induced bronchopulmonary dysplasia (BPD) and chronic lung disease (CLD) to outstanding investigators from multiple institutions dedicated to sharing collaborative protocols and tissue specimens. In recent years, the original form of BPD described in the 1960's has become less common due to improvements in oxygenation and ventilatory strategies and the use of postnatal exogenous surfactant, and has been replaced by a less severe from of disease primarily in extremely small immature infants, called chronic lung disease of infancy (CLD). The baboon models of BPD and CLD are unique in the world; they develop disease that is very similar, if not identical, of human disease but in a controlled environment. The Southwest Foundation for Biomedical Research and the University of Texas Health Science Center at San Antonio have the breeding colony and the scientific personnel to support the proposed BPD Resource Core. The specific aims of the BPD Resource Core are: 1) To breed baboons to produce pregnancies of known gestational ages, and to delivery by caesarian section 100 timed pregnancies per year, to provide the premature infants that will be shared by multiple investigators. 2) To maintain these premature infant baboons in a neonatal intensive care environment for short periods of up to 14 days, utilizing several well-defined treatment protocols, and long-term outcomes in 1 to 2 month and 42 week survivors, the latter the baboon equivalent of a 2 year old human infant in whom alveolarization should be complete. 3) To provide tissue specimens taken at the time of delivery, during the animal's clinical course, and at necropsy in as ideal and timely a manner as possible, and tailored to each investigator's needs. 4) To provide a Data Management Core for animal information retrieval. This U-10 program brings together the enthusiasm and competence of established investigators with varying backgrounds and expertise who are committed to examining the various aspects of lung development and how, when interrupted, the fetus adapts to the extrauterine environment. It allows, at a national level, a continuing influx of outstanding scientists to address the major deficiencies in our knowledge concerning BPD/CLD.

The overall goal of this cooperative research program is to develop a multi- institutional research effort to address the mechanisms of postnatal lung pathobiology that lead to chronic lung disease and to provide a unique resource center of prematurely delivered baboons with induced bronchopulmonary dysplasia (BPD) and chronic lung disease (CLD) to outstanding investigators from multiple institutions dedicated to sharing collaborative protocols and tissue标本。近年来，由于氧合和通气策略的改善和产后外源性表面活性剂的使用，1960年代描述的BPD的原始形式变得越来越不常见，并且已被极其小的不成熟的婴儿（称为慢性肺病婴儿疾病（CLD））所取代。 BPD和CLD的狒狒模型在世界上是独一无二的。他们发展出对人类疾病非常相似的疾病，但在受控环境中。西南生物医学研究基金会和得克萨斯大学圣安东尼奥分校的健康科学中心拥有育种殖民地和科学人员，以支持拟议的BPD资源核心。 BPD资源核心的具体目的是：1）繁殖狒狒以产生已知胎龄的妊娠，并每年通过凯撒的第100节定时怀孕，以提供由多个研究人员共享的早产婴儿。 2）在短时间内，在新生儿重症监护环境中维持这些早产的婴儿狒狒，最多14天，利用几种定义明确的治疗方案，并在1至2个月中的长期结局和42周的幸存者中的长期结局，后者是狒狒在幼虫中应完成的2岁婴儿的狒狒。 3）提供在分娩时，在动物的临床过程中摄取的组织标本，并在尸检时尽可能及时地进行尸检，并根据每个研究者的需求进行量身定制。 4）为动物信息检索提供数据管理核心。该U-10计划汇集了具有不同背景和专业知识的既定调查员的热情和能力，他们致力于检查肺发育的各个方面，以及当被中断时，胎儿如何适应外部环境。在国家一级，它允许持续的杰出科学家持续涌入，以解决我们有关BPD/CLD的知识中的主要缺陷。