COLLABORATIVE PROGRAM IN BPD

BPD 合作项目

• 批准号: 7716033
• 负责人: JACQUELINE Jones COALSON
• 金额: $ 2.26万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716033
• 关键词: Alveolar; Animals; Bronchopulmonary Dysplasia; Cesarean section; Chloride Anion Exchanger; Chronic lung disease; Clinical; Closure; Computer Retrieval of Information on Scientific Projects Database; Controlled Environment; Core Facility; Development; Disease; Environmental air flow; Funding; Gestational Age; Goals; Grant; Growth Factor; Hormones; Hyaluronan; Hypoxia Inducible Factor; Immunity; Infant; Information Retrieval; Institution; Lung diseases; Methods; Modeling; Molecular Target; Neonatal Intensive Care Units; Neuropeptides; Nitric Oxide; Papio; Pregnancy; Prematurity of fetus; Primates; Purpose; Regulation; Research; Research Personnel; Resources; Role; SLC26A3 gene; Scientist; Serpins; Source; Specimen; Superoxides; Time; Tissues; Title; United States National Institutes of Health; Vascularization; data management; day; human disease; infancy; lung development; lung injury; lung maturation; mimetics; premature lungs; prevent; programs; receptor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The baboon model of bronchopulmonary dysplasia (BPD) developed over the last 19 years at SFBR is unique. Baboons develop a disease that is very similar, if not identical, to the human disease of BPD, but in a controlled environment. The purpose of the core facility remains the same: The NICU provides a model of lung disease in premature baboon infants and scientists and doctors across the US. are able to try new methods of curbing the lifelong effects of the disease. The ultimate goal is to prevent lung disease associated with prematurity. The specific aims of the BPD Resource Core are 1) to produce and deliver by cesarean section 100 timed baboon pregnancies per year of known gestational ages, 2) to maintain these premature baboons in a neonatal intensive care unit for up to 28 days, 3) to provide tissue specimens taken at the time of delivery, during the animal's clinical course, and tailored to each investigator's needs, 4) to provide a Data Management Core for animal information retrieval. During this funding period, the BPD Resource has brought together 9 established investigators with various backgrounds and expertise who are examining the roles of several hormones, selected growth factors, and other modulators on lung maturation. Each is funded by a NIH R01 grant. Ten project titles listed below (from the 9 PIs and a study overseen by Dr. Coalson). The focus in the first 5 years of the project was to develop better understanding of BPD in the baboon model; the emphasis during the current 5 years is to focus on chronic lung disease of infancy, which involves lack of alveolar formation and vascularization of the premature lung. Projects 1. "Ventilation model and CNS inlury in Baboons with BPD"  Dr. Terrie Inder 2. "Analysis of Airway Serpins in Baboon Models of BPD " - Dr. Sule Cataltepe 3. "Closure of the primate ductus urteroisus" - Dr. Ronald Clyman 4. "Treatment of BPD using Mimetics of Superoxide Dismutuse " - Dr. James Crapo 5. "Regulation of Microvascular Development in BPD " - Dr. William Maniscalco 6. "Molecular Targets in BPD" - Dr. Richard Pierce 7. "Hyaluronan and its Receptors in BPD '' - Dr. Savani 8. "Nitric Oxide in Lung Development and CLD " - Dr. Phillip Shaul 9. "Neuropeptides, Immunity, and Lung Injury" - Dr. Mary Sunday 10. "Hypoxia-inducible factors in BPD " - Dr. Carl White

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 在过去的19年中，SFBR开发的支气管肺发育不良（BPD）的狒狒模型是独一无二的。 狒狒发展出一种与BPD人类疾病非常相似的疾病，但在受控环境中。 核心设施的目的保持不变：NICU在美国的早产狒狒，科学家和医生中提供了一种肺部疾病模型。能够尝试遏制疾病终身影响的新方法。最终目标是预防与早产相关的肺部疾病。 BPD资源核心的具体目的是1）剖宫产第100节，每年已知的妊娠年龄定时怀孕，2）在新生儿重症监护病房中维持这些早熟的狒狒，最多28天，最多28天，3）提供在动物临床过程中为动物提供的动物培训时，为动物​​的尾部提供了一项研究，并提供了每种研究，并为动物的尾部提供了一项研究，并提供了一个研究，并提供了一个研究，并提供了4个研究，并提供了4个项目。在此资助期间，BPD资源汇集了9位具有各种背景和专业知识的研究人员，他们正在研究几种激素，选定的生长因子以及其他调节剂在肺部成熟方面的作用。 每个人都由NIH R01赠款资助。下面列出的十个项目标题（来自9个PI和Coalson博士监督的研究）。 该项目的前5年的重点是在狒狒模型中更好地了解BPD。目前5年期间的重点是关注婴儿期慢性肺疾病，这涉及缺乏肺泡形成和早产肺的血管形成。 项目 1。“通风模型和CNS Inlury在狒狒中与BPD” 2。“ BPD狒狒模型中的气道丝氨酸分析” - Sule Cataltepe博士 3。“灵长类动管道的关闭” -Ronald Clyman博士 4。“使用超氧化物张开的模拟物治疗BPD” -James Crapo博士 5。“ BPD中微血管发育的调节” -William Maniscalco博士 6。“ BPD中的分子靶标” -Richard Pierce博士 7。“ Hyaluronan及其在BPD中的受体” - Savani博士 8。“肺发育中的一氧化氮和CLD” -Phillip Shaul博士 9。“神经肽，免疫和肺部受伤” - 玛丽·星期日博士 10。“ BPD中的缺氧诱导因素” -Carl White博士