COLLABORATIVE PROGRAM IN BPD

BPD 合作项目

• 批准号: 2230130
• 负责人: JACQUELINE Jones COALSON
• 金额: $ 147.15万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-07-20 至 1999-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2230130
• 关键词: baboons; bronchopulmonary dysplasia; cooperative study; disease /disorder model; growth /development; neonatal intensive care; pathology; premature infant animal; respiratory distress syndrome of newborn

Little progress has been made to date towards the prevention of treatment of BPD. Even exogenous surfactant therapy, which acutely causes significant reductions in oxygen requirements and mortality from RDS, has had little impact on the 70-90% incidence of BPD in newborn survivors with birthweights of <1000 grams. The overall goal of this cooperative research program is to develop a multi-institutional research effort to address the mechanisms of postnatal lung pathobiology that lead to chronic lung disease and to provide a unique resource center of prematurely delivered baboons with induced bronchopulmonary dysplasia to outstanding investigators from multiple institutions dedicated to sharing collaborative protocols and tissue specimens. The baboon models of BPD are unique in the world; they develop disease that is very similar, if not identical, to the human disease but in a controlled environment. Unlike human clinical studies, gestational age is tightly controlled and results are not confounded by variable causes of premature delivery. The Southwest Biomedical Research Foundation has approximately 2700 baboons, the breeding colony and the scientific personnel to oversee all aspects of the proposed BPD Resource Core. The specific aims of the BPD Resource Core are: 1) To breed baboons to produce pregnancies of known gestational ages, and to deliver by Caesarian section 100 timed pregnancies per year, to provide the premature infants that will be shared by multiple investigators. 2) To maintain these premature infant baboons in a neonatal intensive care environment for periods of up to 14 days, utilizing several well-defined treatment protocols. Long-term outcomes will be examined in 33-35 week survivors, the baboon equivalent of a 2 year old human infant in whom alveolarization should be complete. 3) To provide tissue specimens taken at the time of delivery, during the animal's clinical course, and at necropsy in as ideal and timely a manner as possible, and tailored to each investigator's needs. 4) To provide a Data Management Core for animal information retrieval.

迄今为止，预防治疗方面几乎没有取得进展 BPD。即使是外源表面活性剂疗法，急性引起 RDS的氧气需求和死亡率的大幅降低已有 在新生儿幸存者中，对BPD的70-90％发病率几乎没有影响 出生体重<1000克。这个合作的总体目标 研究计划是开发多机构的研究工作 解决导致产后肺病变学的机制 慢性肺病，并提供独特的资源中心 过早地递送出具有诱导支气管肺发育不良的狒狒 来自多个致力于共享的机构的杰出调查员 协作方案和组织标本。 BPD的狒狒模型 在世界上是独一无二的；他们发展出非常相似的疾病 与人类疾病不相同，而是在受控环境中。 与人类的临床研究不同，胎龄受到严格控制， 结果不会因过早交付的变量而混淆。这 西南生物医学研究基金会有大约2700个狒狒， 繁殖殖民地和科学人员监督各个方面 提出的BPD资源核心。 BPD资源的具体目的 核心是：1）繁殖狒狒以产生已知妊娠的怀孕 年龄，每年通过凯撒分1节的定时怀孕， 提供将由多个分享的早产婴儿 调查人员。 2）将这些过早的婴儿狒狒保持在 新生儿重症监护环境长达14天， 利用几种定义明确的治疗方案。长期结局 将在33-35周的幸存者中进行检查，相当于2 牙槽化应完整的年龄的人类婴儿。 3）到 提供在分娩时采用的组织标本 动物的临床课程，在尸检中是理想和及时的 尽可能量身定制每个调查员的需求。 4）提供一个 动物信息检索的数据管理核心。