Medical Technologies Innovation and Knowledge Centre Phase 2 Regenerative Devices

医疗技术创新和知识中心二期再生设备

基本信息

批准号：
EP/N00941X/1
负责人：
Ruth Wilcox
金额：
$ 449.62万
依托单位：
University of Leeds
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2015
资助国家：
英国
起止时间：
2015 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FN00941X%2F1
关键词：
Medical Technologies Innovation Knowledge Centre

项目摘要

Regenerative devices (scaffolds, biomaterials and interventions) which can repair and regenerate tissues using the patients` own cells, can be translated into successful clinical products and deliver patient benefit at much lower cost and risk and in shorter timescales then other regenerative therapies such as culture expanded cell therapies or molecular (drug) therapies. It is estimated that the global market for regenerative devices will grow to £50bn by 2020 and this offers a real opportunity to grow a £1bn per year industry in the UK in this field. The UK has genuine research strengths in the areas of biomaterials and tissue engineering, musculoskeletal mechanics (prioritised by EPSRC) and regenerative medicine. Regenerative medicine is one of the eight great technologies prioritised across the Research Councils. Research discoveries, new knowledge, outputs and outcomes are often not ready for uptake by industry to take forward through product development to the market and patient benefit. New technologies need to be advanced and de-risked. The clinical needs, potential products and markets need to be defined in order to make them attractive for investment, product development and clinical trials by industry. In the Medical Technologies Innovation and Knowledge Centre (MTIKC) Phase 1, working with industry and clinical partners, we have developed a professional innovation team and a unique innovation and translation process, creating a multidisciplinary research and innovation ecosystem. We have successfully identified research outcomes and new knowledge and created, advanced and translated technology across the innovation valley of death, enabling successful investment (over £100m) by industry and the private sector in new product development. Some products have already progressed to clinical trials and commercialisation and are realising patient benefits. We have established a continuous innovation pipeline of over fifty proofs of concept technology projects.Over the next five years in MTIKC Phase 2, we will address unmet clinical needs and market opportunities in wound repair, cardiovascular repair, musculoskeletal tissue repair, maxillofacial reconstruction, dental reconstruction and general surgery and diversify our research supply chain to over ten other Universities. We will support 150 collaborative projects with industry and initiate forty new industry inspired and academically led proof of concept projects, which are predicted to lead to a further £100m investment by the private sector in subsequent product development. This will enable a sustainable research and product development pipeline to be established in the UK which will support a £1bn / year industry in regenerative devices beyond 2020.

再生设备（支架、生物材料和干预措施）可以利用患者自身的细胞修复和再生组织，可以转化为成功的临床产品，并以比培养等其他再生疗法低得多的成本和风险以及更短的时间为患者带来益处据估计，到 2020 年，全球再生设备市场将增长到 500 亿英镑，这为英国每年增长 10 亿英镑的行业提供了真正的机会。英国在生物材料和组织工程、肌肉骨骼力学（EPSRC 优先考虑）和再生医学领域拥有真正的研究优势，再生医学是研究委员会优先考虑的八项重大技术之一。成果往往还没有准备好被行业通过产品开发推向市场，并且需要推进新技术并降低风险。需要确定临床需求、潜在产品和市场。为了使它们对行业的投资、产品开发和临床试验具有吸引力，在医疗技术创新和知识中心（MTIKC）一期中，我们与行业和临床合作伙伴合作，建立了专业的创新团队和独特的创新和技术。我们已经成功地确定了研究成果和新知识，并在创新死亡之谷创造了先进的和转化的技术，从而使行业和私营部门能够在新领域成功投资（超过 1 亿英镑）。部分产品已进入临床。我们已经建立了超过 50 个概念验证技术项目的持续创新管道。在 MTIKC 第 2 阶段的未来五年中，我们将解决伤口修复、心血管修复方面未满足的临床需求和市场机会。、肌肉骨骼组织修复、颌面重建、牙科重建和普通外科，并将我们的研究供应链多样化到其他十多所大学。我们将支持 150 个与行业合作的项目，并启动 40 个受行业启发和学术主导的新项目。概念验证项目预计将导致私营部门在后续产品开发中投资 1 亿英镑，这将使英国建立可持续的研究和产品开发渠道，从而支持每年 10 亿英镑的进一步产业发展。 2020 年以后的再生设备。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Manufacturing Porous Microspheres from Bioactive Glasses for Orthobiologics Applications.

用生物活性玻璃制造多孔微球用于骨科生物应用。

DOI：
发表时间：
2019
期刊：
影响因子：
0
作者：
Ahmed, I
通讯作者：
Ahmed, I

Influence of hip joint simulator design and mechanics on the wear and creep of metal-on-polyethylene bearings.

DOI：
10.1177/0954411915620454
发表时间：
2016-05
期刊：
Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
影响因子：
0
作者：
Ali M;Al-Hajjar M;Partridge S;Williams S;Fisher J;Jennings LM
通讯作者：
Jennings LM

A comparison between electromechanical and pneumatic-controlled knee simulators for the investigation of wear of total knee replacements.

DOI：
10.1177/0954411917696519
发表时间：
2017-07
期刊：
Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
影响因子：
0
作者：
Abdelgaied A;Fisher J;Jennings LM
通讯作者：
Jennings LM

The Influence of Kinematic Conditions and Variations in Component Positioning on the Severity of Edge Loading and Wear of Ceramic-on-Ceramic Hip Bearings

运动条件和部件定位变化对陶瓷陶瓷髋关节轴承边缘载荷和磨损严重程度的影响