Medical Technologies Innovation and Knowledge Centre Phase 2 Regenerative Devices

医疗技术创新和知识中心二期再生设备

基本信息

批准号：
EP/N00941X/1
负责人：
Ruth Wilcox
金额：
$ 449.62万
依托单位：
University of Leeds
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2015
资助国家：
英国
起止时间：
2015 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FN00941X%2F1
关键词：
Medical Technologies Innovation Knowledge Centre

项目摘要

Regenerative devices (scaffolds, biomaterials and interventions) which can repair and regenerate tissues using the patients` own cells, can be translated into successful clinical products and deliver patient benefit at much lower cost and risk and in shorter timescales then other regenerative therapies such as culture expanded cell therapies or molecular (drug) therapies. It is estimated that the global market for regenerative devices will grow to £50bn by 2020 and this offers a real opportunity to grow a £1bn per year industry in the UK in this field. The UK has genuine research strengths in the areas of biomaterials and tissue engineering, musculoskeletal mechanics (prioritised by EPSRC) and regenerative medicine. Regenerative medicine is one of the eight great technologies prioritised across the Research Councils. Research discoveries, new knowledge, outputs and outcomes are often not ready for uptake by industry to take forward through product development to the market and patient benefit. New technologies need to be advanced and de-risked. The clinical needs, potential products and markets need to be defined in order to make them attractive for investment, product development and clinical trials by industry. In the Medical Technologies Innovation and Knowledge Centre (MTIKC) Phase 1, working with industry and clinical partners, we have developed a professional innovation team and a unique innovation and translation process, creating a multidisciplinary research and innovation ecosystem. We have successfully identified research outcomes and new knowledge and created, advanced and translated technology across the innovation valley of death, enabling successful investment (over £100m) by industry and the private sector in new product development. Some products have already progressed to clinical trials and commercialisation and are realising patient benefits. We have established a continuous innovation pipeline of over fifty proofs of concept technology projects.Over the next five years in MTIKC Phase 2, we will address unmet clinical needs and market opportunities in wound repair, cardiovascular repair, musculoskeletal tissue repair, maxillofacial reconstruction, dental reconstruction and general surgery and diversify our research supply chain to over ten other Universities. We will support 150 collaborative projects with industry and initiate forty new industry inspired and academically led proof of concept projects, which are predicted to lead to a further £100m investment by the private sector in subsequent product development. This will enable a sustainable research and product development pipeline to be established in the UK which will support a £1bn / year industry in regenerative devices beyond 2020.

可以使用患者自己的细胞来修复和再生组织的再生装置（脚手架，生物材料和干预措施）可以转化为成功的临床产品，并以更低的成本和风险和更短的时间表范围和其他再生疗法（如培养细胞疗法或分子（药物）（药物）疗法等其他再生疗法。据估计，到2020年，全球再生设备市场将增长到500亿英镑，这提供了一个真正的机会，可以在这一领域的英国增加每年10亿英镑的行业。英国在生物材料和组织工程，肌肉骨骼力学（由EPSRC优先）和再生医学领域具有真正的研究优势。再生医学是整个研究委员会优先考虑的八种伟大技术之一。研究发现，新知识，产出和成果通常并没有准备好通过产品开发到市场和患者福利的产品来吸收。新技术需要先进和危险。需要定义临床需求，潜在的产品和市场，以使其对行业的投资，产品开发和临床试验有吸引力。在与行业和临床合作伙伴合作的《医疗技术创新与知识中心》（MTIKC）中，我们开发了专业的创新团队以及独特的创新和翻译过程，创建了一个多学科研究和创新生态系统。我们已经成功地确定了研究成果和新知识，并在整个死亡的创新谷创建，高级和翻译的技术，从而在新产品开发中成功投资（超过1亿英镑）和私营部门。一些产品已经发展为临床试验和商业化，并正在实现患者的益处。我们已经建立了一条持续的创新管道，该管道是五十多个概念技术项目的证据。在MTIKC 2阶段的接下来的五年中，我们将解决未满足的临床需求和伤口修复，心血管修复，肌肉骨骼组织修复，上颌面重建，杂交重建，牙科再造，牙科重建，牙科外科手术和一般研究供应链的供应链，并多样的研究链，以多种多样的研究。我们将支持与行业的150个合作项目，并启动40个新行业，并准确地领导了概念验证项目，预计这些项目将导致私营部门在随后的产品开发中进一步投资1亿英镑。这将使在英国建立一条可持续的研究和产品开发管道，该管道将在2020年以后的再生设备中为一个每年10亿英镑的行业提供支持。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Manufacturing Porous Microspheres from Bioactive Glasses for Orthobiologics Applications.

用生物活性玻璃制造多孔微球用于骨科生物应用。

DOI：
发表时间：
2019
期刊：
影响因子：
0
作者：
Ahmed, I
通讯作者：
Ahmed, I

Influence of hip joint simulator design and mechanics on the wear and creep of metal-on-polyethylene bearings.

DOI：
10.1177/0954411915620454
发表时间：
2016-05
期刊：
Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
影响因子：
0
作者：
Ali M;Al-Hajjar M;Partridge S;Williams S;Fisher J;Jennings LM
通讯作者：
Jennings LM

A comprehensive combined experimental and computational framework for pre-clinical wear simulation of total knee replacements.