Optimisation of vertebroplasty to minimise adjacent vertebral failure

优化椎体成形术以尽量减少邻近椎体衰竭

• 批准号: EP/D002710/1
• 负责人: Ruth Wilcox
• 金额: $ 26.91万
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FD002710%2F1
• 关键词: Optimisation; vertebroplasty; minimise; adjacent; vertebral

Many elderly people suffer from osteoporosis, which causes their bones to break very easily. One of the most common places for a fracture to occur is in the vertebrae of the spine. These fractures are difficult to treat and many patients suffer from long-term pain. Recently, a new method of keyhole surgery has been introduced to treat these types of injury. The treatment, called 'vertebroplasty' involves injecting a special cement through a fine needle into the spine to hold the fracture together. Early results have been positive, with the majority of patients saying they are in much less pain after the treatment. However, recently there have been reports that vertebroplasty may increase the risk of the patient having more fractures in the surrounding vertebrae. At the moment, little is know about how stiff the cement should be or how much to inject. The aim of this project is to develop computer models of the spine that can be used to predict what effects the cement will have on the surrounding region of the spine. To check these models make the right predictions, the results first need to be checked against experimental tests undertaken in the laboratory. Then, the computer models will be used to compare many different types and volumes of cement. The aim is to find the optimum combination that will reduce the risk of more fractures happening in the surrounding vertebrae.

许多老年人患有骨质疏松症，这会导致骨骼很容易折断。骨折最常见的地方之一是脊柱的椎骨。这些骨折很难治疗，许多患者患有长期疼痛。最近，已经引入了一种新的钥匙孔手术方法来治疗这类损伤。这种称为“椎体成形术”的处理涉及通过细针向脊柱注入特殊的水泥，以将裂缝固定在一起。早期结果是阳性的，大多数患者说治疗后的疼痛要小得多。但是，最近有报道称，椎体成形术可能会增加患者在周围椎骨中骨折更多的风险。目前，几乎不知道水泥应该是多么僵硬或注入多少。该项目的目的是开发脊柱的计算机模型，该模型可用于预测水泥对脊柱周围区域的影响。为了检查这些模型做出正确的预测，首先需要根据实验室进行的实验测试来检查结果。然后，计算机模型将用于比较许多不同类型和水泥的水泥。目的是找到最佳组合，以降低周围椎骨发生更多断裂的风险。

项目成果

Vertebroplasty: Patient and treatment variations studied through parametric computational models.

椎体成形术：通过参数计算模型研究患者和治疗的变化。

• DOI: 10.1016/j.clinbiomech.2013.07.012
• 发表时间: 2013-10
• 期刊: Clinical biomechanics (Bristol, Avon)
• 作者: Wijayathunga VN;Oakland RJ;Jones AC;Hall RM;Wilcox RK
• 通讯作者: Wilcox RK

FE models of human vertebra - effect of image-based material property assignment

人体椎骨的有限元模型 - 基于图像的材料属性分配的效果

• 发表时间: 2008
• 作者: V Wijayathunga

Prophylactic Vertebroplasty: A Parametric Finite Element Study

预防性椎体成形术：参数有限元研究

• 发表时间: 2009
• 作者: V Wijayathunga

Finite Element Analysis of Vertebrae Using Specimen-specific Methods: Review of Methods and Accuracy.

使用特定于标本的方法对椎骨进行有限元分析：方法和准确性的审查。

• 发表时间: 2008
• 期刊: Journal of Medical Biomechanics
• 作者: V Wijayathunga