Novel design analysis tools to increase precision and reduce variation in hip replacement performance

新颖的设计分析工具可提高精度并减少髋关节置换性能的变化

基本信息

批准号：
EP/N02480X/1
负责人：
Ruth Wilcox
金额：
$ 130.67万
依托单位：
University of Leeds
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2016
资助国家：
英国
起止时间：
2016 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FN02480X%2F1
关键词：
Novel design analysis tools increase

项目摘要

Over 60 million patients worldwide suffer from hip osteoarthritis, and increasing numbers of patients are requiring total hip replacement surgery. Although the surgery is highly successful, the ageing active population and rise in obesity are placing extra demands on hip replacements: devices must now withstand higher loads and survive for longer durations in the body. The number of revision surgery procedures to replace worn out or damaged components is rising, and there is a need to develop more robust hip replacement devices that can withstand these increasing demands across all patient groups. One of the major causes of failure of hip replacements is due to wear and fatigue of the device components. These damage processes can increase dramatically if the components are not well aligned relative to each another, or relative to the direction of the loads they experience in the body. There can be many factors which affect the alignment, including the device design and surgical procedure as well as the patient anatomy and biomechanics. In this proposal, we will develop computer models to simulate hip replacement performance under different misalignment conditions. We will incorporate patient and surgical variations into the model so that we can define exactly what levels of alignment are required for specific devices to operate adequately. This will enable us to provide better guidance on the choice of device for individual patients to reduce the likelihood of misalignment. It will also help inform surgeons on the positioning of the components for different patient characteristics. We will work with a major orthopaedic company (DePuy Synthes) to integrate the computer models into their new product development process, so that the next generation of devices can be designed to be more robust to alignment variations, and surgical tools can be developed to help align devices with better precision in the most critical directions. We will also work with regulators and standards agencies to develop new testing requirements that take account of the variations in patients and surgery, so that all new products will have to undergo more robust testing before they are introduced onto the market. In the longer term, the methods we develop will help extend the lifetime and reliability of the next generation of hip replacements and enable these devices to meet the increasing demands of our ageing active population.

全球超过6000万患者患有髋关节骨关节炎，越来越多的患者需要全髋关节置换手术。尽管手术非常成功，但肥胖症的活性人群和肥胖症的增加仍对髋关节置换提出了额外的需求：现在，设备必须承受更高的负载并在体内持续时间更长的持续时间。更换磨损或损坏的组件的修订手术手术程序的数量正在增加，并且有必要开发更强大的髋关节置换设备，以承受所有患者群体中日益增长的需求。髋关节置换失败的主要原因之一是由于设备组件的磨损和疲劳。如果组件相对于彼此或相对于它们体内体验到的载荷方向的相对于彼此，这些损伤过程可能会大大增加。可能会有许多影响对齐的因素，包括设备设计和外科手术以及患者的解剖学和生物力学。在此提案中，我们将开发计算机模型，以模拟在不同的未对准条件下的髋关节替换性能。我们将将患者和手术变化纳入模型，以便我们可以准确定义特定设备充分操作所需的对齐水平。这将使我们能够为单个患者选择设备的选择提供更好的指导，以减少未对准的可能性。它还将有助于将不同患者特征的组件定位告知外科医生。我们将与一家主要的骨科公司（DEPUY合成）合作，将计算机模型集成到其新的产品开发过程中，以便可以设计下一代设备以更适合对齐变化，并可以开发出手术工具，以帮助在最关键方向上更好地对准设备。我们还将与监管机构和标准机构合作，以开发新的测试要求，以考虑患者和手术的差异，因此所有新产品都必须在将其引入市场之前必须进行更强大的测试。从长远来看，我们开发的方法将有助于延长下一代髋关节置换的生命周期和可靠性，并使这些设备能够满足我们老龄化活性人群的日益增长的需求。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Computationally efficient modelling of hip replacement separation due to small mismatches in component centres of rotation.

DOI：
10.1016/j.jbiomech.2019.07.040
发表时间：
2019-10
期刊：
Journal of biomechanics
影响因子：
2.4
作者：
L. Etchels;Lin Wang;M. Al-Hajjar;S. Williams;J. Thompson;G. Isaac;R. Wilcox;A. Jones
通讯作者：
L. Etchels;Lin Wang;M. Al-Hajjar;S. Williams;J. Thompson;G. Isaac;R. Wilcox;A. Jones

Importance of dynamics in the finite element prediction of plastic damage of polyethylene acetabular liners under edge loading conditions.

动力学在边缘加载条件下聚乙烯髋臼衬垫塑性损伤有限元预测中的重要性。

DOI：
10.1016/j.medengphy.2021.07.010
发表时间：
2021
期刊：
Medical engineering & physics
影响因子：
2.2
作者：
Jahani F
通讯作者：
Jahani F

Computational Investigations Of Edge Loading In Hip Replacement Bearings: Getting The Right Tool For The Job

髋关节置换轴承边缘载荷的计算研究：找到适合工作的正确工具

DOI：
发表时间：
2021
期刊：
影响因子：
0
作者：
Etchels L
通讯作者：
Etchels L

Impingement in total hip arthroplasty: A geometric model.

DOI：
10.1177/09544119211069472
发表时间：
2022-02-11
期刊：
Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
影响因子：
0
作者：
Pryce GM;Sabu B;Al-Hajjar M;Wilcox RK;Thompson J;Isaac GH;Board T;Williams S
通讯作者：
Williams S

Dynamic Acetabular Cup Orientation during Gait: A Study of Fast- and Slow-Walking Total Hip Replacement Patients.

步态过程中的动态髋臼杯定向：对快走和慢走全髋关节置换患者的研究。