Optimising knee therapies through improved population stratification and precision of the intervention

通过改善人群分层和干预精度来优化膝关节治疗

基本信息

批准号：
EP/P001076/1
负责人：
Ruth Wilcox
金额：
$ 504.89万
依托单位：
University of Leeds
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2016
资助国家：
英国
起止时间：
2016 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FP001076%2F1
关键词：
Optimising knee therapies through improved

项目摘要

Our vision is that patients with knee pain receive the right treatment at the right time.In the UK, one third of people aged over 45 have sought treatment for osteoarthritis, and the disease costs the NHS over £5 billion per year. The knee is the most common site for osteoarthritis, with over four million sufferers in England alone. The aging population with expectations of more active lifestyles, coupled with the increasing demand for treatment of younger and more active patients, are challenging the current therapies for knee joint degeneration. There is a major need for effective earlier stage interventions that delay or prevent the requirement for total knee replacement surgery. There are large variations in patients' knees and the way that they function, and it is important that this variation is taken into account when treatments are developed, so that the right treatment can be matched to the right patient. Through this ambitious programme of research we will develop novel testing methods that combine laboratory-based simulation and computer modelling to predict the mechanical performance of new therapies for the knee and enable their design and usage to be optimised. Importantly these tests will take into account the variation in patients' anatomy and knee biomechanics, as well as variations in device design and surgical technique. This will enable different therapies, or different variants of a device, to be matched to different patient groups.The tools will be applied to existing treatments using clinical data to help validate that our model predictions are correct. The outcomes will better define which patients will benefit from a particular intervention and help optimise their usage. We will then apply the methods to new and emerging treatments, including regenerative devices, so that they can be tested and optimised before costly clinical trials take place. We will use these examples as case studies to demonstrate how the new testing methods can optimise the products before they reach the patient, and we will work with industry, standards agencies and regulators to promote the adoption of these methods across the sector. This programme will benefit patients, the NHS and the growing UK industry and science base that are developing new therapies for the knee.

我们的愿景是让膝盖疼痛患者在正确的时间接受正确的治疗。在英国，三分之一的 45 岁以上的人曾寻求骨关节炎的治疗，这种最常见的疾病每年花费超过 50 亿英镑。仅在英格兰就有超过 400 万骨关节炎患者，人口老龄化对更积极的生活方式的期望，加上对年轻和更活跃患者的治疗需求不断增加，正在对当前的膝关节退行性变治疗提出挑战。主要需要有效的早期干预措施可以延迟或避免进行全膝关节置换手术。患者的膝关节及其功能存在很大差异，因此在制定治疗方案时考虑到这种差异非常重要，以便通过这个雄心勃勃的研究计划，我们将开发新的测试方法，基于实验室的模拟和计算机建模来预测膝关节新疗法的机械性能，并将其设计和使用结合起来进行优化。重要的是，这些测试将考虑患者的差异。解剖学和膝关节生物力学，以及设备设计和手术技术的变化，这将使不同的疗法或设备的不同变体能够适应不同的患者群体。这些工具将利用临床数据应用于现有的治疗方法，以提供帮助。验证我们的模型预测是正确的。结果将更好地确定哪些患者将从特定干预中受益，并帮助优化他们的使用，然后我们将这些方法应用于新兴的治疗方法，包括再生设备，以便对其进行测试和使用。在进行昂贵的临床试验之前进行优化。将使用这些例子作为案例研究，展示新的测试方法如何在产品到达患者之前对其进行优化，我们将与行业、标准机构和监管机构合作，推动这些方法在整个行业的采用，该计划将使该计划受益。患者、NHS 以及不断发展的英国工业和科学基础正在开发新的膝盖疗法。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Evaluation of the Mechanical Behaviour of Osteochondral Grafts and their Composite Parts: Naturally Variable Tissues.

骨软骨移植物及其复合部件的机械行为评估：自然可变组织。

DOI：
发表时间：
2018
期刊：
影响因子：
0
作者：
Casper-Taylor, M
通讯作者：
Casper-Taylor, M

Simple geometry tribological study of osteochondral graft implantation in the knee.

DOI：
10.1177/0954411917751560
发表时间：
2018-03
期刊：
Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
影响因子：
0
作者：
Bowland P;Ingham E;Fisher J;Jennings LM
通讯作者：
Jennings LM

Investigation of the Influence of Material Properties on Osteochondral Graft Fixation: A Finite Element Analysis

材料特性对骨软骨移植物固定影响的研究：有限元分析