Optimising knee therapies through improved population stratification and precision of the intervention

通过改善人群分层和干预精度来优化膝关节治疗

基本信息

批准号：
EP/P001076/1
负责人：
Ruth Wilcox
金额：
$ 504.89万
依托单位：
University of Leeds
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2016
资助国家：
英国
起止时间：
2016 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FP001076%2F1
关键词：
Optimising knee therapies through improved

项目摘要

Our vision is that patients with knee pain receive the right treatment at the right time.In the UK, one third of people aged over 45 have sought treatment for osteoarthritis, and the disease costs the NHS over £5 billion per year. The knee is the most common site for osteoarthritis, with over four million sufferers in England alone. The aging population with expectations of more active lifestyles, coupled with the increasing demand for treatment of younger and more active patients, are challenging the current therapies for knee joint degeneration. There is a major need for effective earlier stage interventions that delay or prevent the requirement for total knee replacement surgery. There are large variations in patients' knees and the way that they function, and it is important that this variation is taken into account when treatments are developed, so that the right treatment can be matched to the right patient. Through this ambitious programme of research we will develop novel testing methods that combine laboratory-based simulation and computer modelling to predict the mechanical performance of new therapies for the knee and enable their design and usage to be optimised. Importantly these tests will take into account the variation in patients' anatomy and knee biomechanics, as well as variations in device design and surgical technique. This will enable different therapies, or different variants of a device, to be matched to different patient groups.The tools will be applied to existing treatments using clinical data to help validate that our model predictions are correct. The outcomes will better define which patients will benefit from a particular intervention and help optimise their usage. We will then apply the methods to new and emerging treatments, including regenerative devices, so that they can be tested and optimised before costly clinical trials take place. We will use these examples as case studies to demonstrate how the new testing methods can optimise the products before they reach the patient, and we will work with industry, standards agencies and regulators to promote the adoption of these methods across the sector. This programme will benefit patients, the NHS and the growing UK industry and science base that are developing new therapies for the knee.

我们的愿景是，膝盖疼痛的患者在适当的时间接受了正确的治疗。在英国，有45岁以上的人中有三分之一感受到骨关节炎的治疗方法，而该疾病每年的NHS损失超过50亿英镑。膝盖是骨关节炎的最常见部位，仅英格兰就有超过四百万的患者。老龄化的人口具有更活跃的生活方式，再加上对年轻和活跃患者的治疗的需求不断增长，这挑战了当前的膝盖关节变性疗法。需要进行有效的早期阶段干预措施，以延迟或阻止对全膝关节置换手术的需求。患者的膝盖及其功能的差异很大，在开发治疗时要考虑这种变化很重要，以便将正确的治疗与合适的患者相匹配。通过这项雄心勃勃的研究计划，我们将开发新的测试方法，结合基于实验室的仿真和计算机建模，以预测膝盖新疗法的机械性能，并使他们的设计和用法能够优化。重要的是，这些测试将考虑患者解剖学和膝关节生物力学的变化，以及设备设计和手术技术的变化。这将使设备的不同疗法或不同患者组匹配。这些工具将使用临床数据应用于现有治疗方法，以帮助验证我们的模型预测是否正确。结果将更好地定义哪些患者将从特定的干预措施中受益，并有助于优化其使用情况。然后，我们将将这些方法应用于新的和新兴的治疗方法，包括再生设备，以便在进行昂贵的临床试验之前对其进行测试和优化。我们将使用这些示例作为案例研究，以证明新的测试方法在到达患者之前如何优化它们，并且我们将与行业，标准机构和监管机构合作，以促进这些方法在整个领域中采用这些方法。该计划将使正在为膝盖开发新疗法的患者，NHS和不断增长的英国行业和科学基础受益。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Evaluation of the Mechanical Behaviour of Osteochondral Grafts and their Composite Parts: Naturally Variable Tissues.

骨软骨移植物及其复合部件的机械行为评估：自然可变组织。

DOI：
发表时间：
2018
期刊：
影响因子：
0
作者：
Casper-Taylor, M
通讯作者：
Casper-Taylor, M

Simple geometry tribological study of osteochondral graft implantation in the knee.

DOI：
10.1177/0954411917751560
发表时间：
2018-03
期刊：
Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
影响因子：
0
作者：
Bowland P;Ingham E;Fisher J;Jennings LM
通讯作者：
Jennings LM

Investigation of the Influence of Material Properties on Osteochondral Graft Fixation: A Finite Element Analysis

材料特性对骨软骨移植物固定影响的研究：有限元分析