VOLTAGE SENSITIVE DYES IN STRIATE CORTEX

纹状皮层中的电压敏感染料

• 批准号: 3262965
• 负责人: GARY G BLASDEL
• 金额: $ 19.77万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-08-01 至 1993-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3262965
• 关键词: Primates; brain imaging /visualization /scanning; cerebral dominance; dyes; electrical measurement; electrical potential; electrophysiology; microelectrodes; neural information processing; vision; visual cortex

DESCRIPTION: (Investigator's abstract): Results using an optical approach to study patterns of cortical organization suggest that response properties in addition to ocular dominance and orientation may be organized laterally (tangentially). Funds are requested in the present proposal to continue this analysis using micro-electrodes in conjunction with optical imaging to determine what these properties are and how they relate to known organizations of ocular dominance and orientation. Each of the proposed experiments will begin with optical techniques that map ocular dominance and orientation and reveal borders where orientation changes abruptly (fractures). Selected 0.5-1.0 mm segments of orientation fractures, iso-orientation bands, and ocular dominance bands will then be examined in greater detail with electrode penetrations. Cells that are isolated from the upper layers will then be tested for response properties that might be organized laterally. These experiments are designed to increase our understanding of visual information processing and associated structure-function relationships in the upper layers of monkey striate cortex.

描述：（研究者的摘要）：使用光学方法的结果 研究皮质组织的模式表明响应特性 除了眼部优势和方向外，还可以横向组织 （切线）。 本提案中要求资金继续 使用微电极与光学成像结合使用的分析 确定这些属性是什么以及它们与已知的关系 眼部主导和取向的组织。 每个提议的 实验将从绘制眼部优势的光学技术开始 定向并揭示临界突然变化的边界 （骨折）。 选择了0.5-1.0 mm的定向骨折， 然后将检查异端方向带和眼部优势频段 具有电极穿透的更大细节。 从 然后，将测试上层的响应属性 横向组织。 这些实验旨在增加我们的 了解视觉信息处理和相关的 猴条纹上层的结构功能关系 皮质。