SIMPLIFIED SYSTEM FOR ULTRASONIC BONE ASSESSMENT

超声波骨骼评估的简化系统

• 批准号: 2867496
• 负责人: Jonathan Kaufman
• 金额: $ 10万
• 依托单位: CYBERLOGIC, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 1999-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2867496
• 关键词: bioimaging /biomedical imaging; bone density; bone fracture; bone imaging /visualization /scanning; diagnosis design /evaluation; disease /disorder proneness /risk; method development; musculoskeletal disorder diagnosis

The long-term objective of this research is to establish ultrasound as a safe, effective, and non-invasive method for assessing fracture risk, an important component in clinical management of osteoporosis. Osteoporosis afflicts over 20 million people in the U.S., responsible for more than 275,000 hip fractures annually. Currently, the primary means for assessment relies on densitometric techniques. These methods subject the patient to ionizing radiation, are relatively expensive, and do not always provide good estimates of bone strength. Ultrasound offers several potential advantages. It is non-ionizing and relatively expensive. Moreover, since ultrasound is a mechanical wave and interacts with bone in a fundamentally different manner than electromagnetic radiation, it may be able to provide more accurate estimates of bone strength compared with current densitometric methods. The goal of this research is to significantly improve the effectiveness of current ultrasonic bone assessment techniques by demonstrating the feasibility of a new ultrasonic system to assess bone. The systems employs a novel parametric signal processing approach is ideally suited for analog and real-time implementation. Thus this research may enable less expensive and easier to use ultrasound devices, which are also less sensitive to various experimental artifacts. The specific aims are to measure a set of new ultrasonic parameters and compare them with presently used features, namely BUA and ultrasound velocity, in calcaneal bone samples. A comparison will be made of their respective capabilities to estimate bone density and bone strength. The comparison will include cost, ease of use, and accuracy and precision of the bone density and bone strength estimates. PROPOSED COMMERCIAL APPLICATION: Osteoporosis is a major health concern in the United States, affecting over 20 million people, and whose incidence is increasing as the average age of the U.S. population increases. An effective, relatively inexpensive and safe technique such as ultrasound for assessing osteoporosis would be an extremely important benefit to the patient population, and represents an enormous commercial opportunity. Ultrasound's importance will grow as various new pharmacologic agents are approved for treatment, thus requiring periodic assessments of efficacy.

这项研究的长期目标是建立超声作为评估骨折风险的安全、有效和非侵入性方法，这是骨质疏松症临床管理的重要组成部分。 在美国，骨质疏松症困扰着超过 2000 万人，每年造成超过 275,000 例髋部骨折。 目前，评估的主要手段依赖于光密度技术。 这些方法使患者受到电离辐射，相对昂贵，并且并不总能提供良好的骨强度估计。 超声波具有多种潜在优势。它是非电离的并且相对昂贵。 此外，由于超声波是一种机械波，并且以与电磁辐射根本不同的方式与骨骼相互作用，因此与当前的密度测定方法相比，它可能能够提供更准确的骨骼强度估计。 这项研究的目标是通过展示新的超声系统评估骨骼的可行性，显着提高当前超声骨骼评估技术的有效性。该系统采用新颖的参数信号处理方法，非常适合模拟和实时实施。 因此，这项研究可以使超声设​​备变得更便宜、更容易使用，而且对各种实验伪影也不太敏感。 具体目标是测量一组新的超声参数，并将其与跟骨样本中目前使用的特征（即 BUA 和超声速度）进行比较。 将比较他们各自估计骨密度和骨强度的能力。 比较将包括成本、易用性以及骨密度和骨强度估计的准确性和精确度。拟议的商业应用：骨质疏松症是美国的一个主要健康问题，影响超过 2000 万人，并且其发病率随着美国人口平均年龄的增加而增加。 一种有效、相对便宜且安全的技术，例如用于评估骨质疏松症的超声技术，将为患者群体带来极其重要的好处，并代表着巨大的商业机会。随着各种新药物被批准用于治疗，超声的重要性将会增加，因此需要定期评估疗效。