A new MR method to determine bone strength

确定骨强度的新 MR 方法

基本信息

批准号：
6924591
负责人：
YI-QIAO SONG
金额：
$ 18.88万
依托单位：
SCHLUMBERGER-DOLL RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-09-01 至 2006-08-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6924591
关键词：
animal tissue bioimaging /biomedical imaging biomechanics bone density bone fracture bone imaging /visualization /scanning diagnosis design /evaluation diagnosis quality /standard disease /disorder proneness /risk musculoskeletal disorder diagnosis nuclear magnetic resonance spectroscopy osteoporosis substantia spongiosa tensile strength

项目摘要

DESCRIPTION (provided by applicant): Osteoporosis is a disorder of the skeleton in which bone strength is abnormally weak and susceptible to fractures from minor trauma. In the United States, about 30 million people have osteoporosis and almost 19 million more have low bone density. Current diagnostics of osteoporosis using bone density does not entirely predict fracture risk, because the internal bone structure, apart from the bone density, contributes significantly to the mechanical strength and thus fracture risk. Recent efforts have been directed toward the high-resolution three-dimensional imaging of the trabecular architecture using Magnetic Resonance Imaging (MRI) and Computed Tomography. The main MR technique (DDIF) used in this proposal is a completely new concept in bone characterization. This study proposes to use the DDIF technique to obtain statistical properties of the trabecular structure at a resolution of about 1 mu m, such as a pore size distribution, instead of high-resolution images. Preliminary work has obtained pore size distributions from bone samples and these distributions have shown a direct correlation with the mechanical properties. The long-term objective of this research is the development of new DDIF-based MR methods for in vivo evaluation of bone strength. Specific aims of the proposed research are: (1) To establish the correlation of DDIF pore size distribution with the mechanical properties of bone, (2) To develop pulse sequences to combine DDIF with MR imaging and spatial localization techniques and to quantify the accuracy of DDIF through numerical analysis. This proposal is designed to develop specific methods to incorporate DDIF into clinical MRI systems and to provide a solid evidence for the new paradigm of bone evaluation. This development will enable the next phase of the project to perform in vivo study of DDIF to further validate the method for clinical osteoporosis diagnostics and the treatment monitoring.

描述（由申请人提供）：骨质疏松症是一种骨骼疾病，骨强度异常薄弱，容易因轻微外伤而骨折。在美国，大约有 3000 万人患有骨质疏松症，另有近 1900 万人骨密度低。目前使用骨密度对骨质疏松症的诊断并不能完全预测骨折风险，因为除了骨密度之外，内部骨结构对机械强度以及骨折风险也有显着影响。最近的研究方向是使用磁共振成像 (MRI) 和计算机断层扫描对小梁结构进行高分辨率三维成像。本提案中使用的主要 MR 技术 (DDIF) 是骨骼表征中的一个全新概念。本研究建议使用DDIF技术来获得分辨率约为1μm的小梁结构的统计特性，例如孔径分布，而不是高分辨率图像。初步工作已经从骨样品中获得了孔径分布，这些分布显示出与机械性能的直接相关性。这项研究的长期目标是开发新的基于 DDIF 的 MR 方法，用于骨强度的体内评估。本研究的具体目标是：(1) 建立 DDIF 孔径分布与骨机械性能的相关性，(2) 开发脉冲序列，将 DDIF 与 MR 成像和空间定位技术相结合，并量化通过数值分析DDIF。该提案旨在开发将 DDIF 纳入临床 MRI 系统的具体方法，并为骨评估的新范式提供坚实的证据。这一进展将使该项目的下一阶段能够进行 DDIF 的体内研究，以进一步验证临床骨质疏松症诊断和治疗监测的方法。