A new MR method to determine bone strength

确定骨强度的新 MR 方法

• 批准号: 6809231
• 负责人: YI-QIAO SONG
• 金额: $ 22.65万
• 依托单位: SCHLUMBERGER-DOLL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2006-08-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6809231
• 关键词: animal tissue; bioimaging /biomedical imaging; biomechanics; bone density; bone fracture; bone imaging /visualization /scanning; diagnosis design /evaluation; diagnosis quality /standard; disease /disorder proneness /risk; musculoskeletal disorder diagnosis; nuclear magnetic resonance spectroscopy; osteoporosis; substantia spongiosa; tensile strength

DESCRIPTION (provided by applicant): Osteoporosis is a disorder of the skeleton in which bone strength is abnormally weak and susceptible to fractures from minor trauma. In the United States, about 30 million people have osteoporosis and almost 19 million more have low bone density. Current diagnostics of osteoporosis using bone density does not entirely predict fracture risk, because the internal bone structure, apart from the bone density, contributes significantly to the mechanical strength and thus fracture risk. Recent efforts have been directed toward the high-resolution three-dimensional imaging of the trabecular architecture using Magnetic Resonance Imaging (MRI) and Computed Tomography. The main MR technique (DDIF) used in this proposal is a completely new concept in bone characterization. This study proposes to use the DDIF technique to obtain statistical properties of the trabecular structure at a resolution of about 1 mu m, such as a pore size distribution, instead of high-resolution images. Preliminary work has obtained pore size distributions from bone samples and these distributions have shown a direct correlation with the mechanical properties. The long-term objective of this research is the development of new DDIF-based MR methods for in vivo evaluation of bone strength. Specific aims of the proposed research are: (1) To establish the correlation of DDIF pore size distribution with the mechanical properties of bone, (2) To develop pulse sequences to combine DDIF with MR imaging and spatial localization techniques and to quantify the accuracy of DDIF through numerical analysis. This proposal is designed to develop specific methods to incorporate DDIF into clinical MRI systems and to provide a solid evidence for the new paradigm of bone evaluation. This development will enable the next phase of the project to perform in vivo study of DDIF to further validate the method for clinical osteoporosis diagnostics and the treatment monitoring.

描述（由申请人提供）： 骨质疏松症是骨骼的一种疾病，其中骨强度异常弱且易受较小创伤的骨折。在美国，约有3000万人患有骨质疏松症，近1900万人的骨密度低。目前使用骨密度对骨质疏松症的诊断不能完全预测骨折的风险，因为除骨密度外，内部骨骼结构对机械强度有显着贡献，从而造成了骨折风险。最近的努力是针对小梁结构的高分辨率三维成像，使用磁共振成像（MRI）和计算机断层扫描。该提案中使用的主要MR技术（DDIF）是骨头表征的全新概念。这项研究建议使用DDIF技术以大约1 Mu M的分辨率（例如孔径分布）而不是高分辨率图像获得小梁结构的统计特性。初步工作已从骨样品中获得孔径分布，这些分布已显示与机械性能有直接相关。这项研究的长期目标是开发基于DDIF的新MR方法，用于体内骨强度评估。拟议的研究的具体目的是：（1）建立DDIF孔径分布与骨骼的机械性能的互动，（2）开发脉冲序列，以将DDIF与MR成像和空间定位技术相结合，并通过数值分析量化DDIF的准确性。该建议旨在开发特定的方法将DDIF纳入临床MRI系统，并为新的骨骼评估范式提供可靠的证据。这种发展将使项目的下一阶段能够在体内研究DDIF，以进一步验证临床骨质疏松诊断和治疗监测方法的方法。