Clinical 3D Ultrasonic Assessment of the Phalanges

指骨的临床 3D 超声评估

• 批准号: 6990293
• 负责人: Jonathan Kaufman
• 金额: $ 10万
• 依托单位: CYBERLOGIC, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-15 至 2006-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6990293
• 关键词: bioimaging /biomedical imaging; bone; bone density; bone fracture; clinical research; computed axial tomography; computer program /software; computer simulation; disease /disorder proneness /risk; human tissue; mathematics; osteoporosis; substantia spongiosa; technology /technique development; ultrasonography; ultrasound

DESCRIPTION (provided by applicant): The long-term objective of this research is to establish ultrasound as a safe, effective, and non-invasive method for assessing fracture risk, an important component in clinical management of osteoporosis. Osteoporosis afflicts over 20 million people in the U.S., responsible for more than 275,000 hip fractures annually. Currently, the primary means for assessment relies on densitometric techniques. These methods subject the patient to ionizing radiation, are relatively expensive, and do not always provide good estimates of bone strength. Ultrasound offers several potential advantages. It is non-ionizing and relatively inexpensive. Moreover, since ultrasound is a mechanical wave and interacts with bone in a fundamentally different manner than electromagnetic radiation, it may be able to provide more accurate estimates of bone strength compared with current densitometric methods. The goal of this research is to significantly improve the effectiveness of current ultrasonic bone assessment techniques by demonstrating the feasibility of a new approach to ultrasonic bone assessment. The approach entails the use of phased array source and receivers to reproducibly measure the finger bones (phalanges). In addition, the method utilizes multidirectional measurements to characterize both the trabecular (distal and proximal) and cortical (diaphyseal) portions. The specific aims are (i) to use 3D ultrasound simulations to demonstrate that phased array source and receiver measurements can reproducibly estimate a set of ultrasound parameters associated with phalangeal bones; and (ii) that combining data obtained from two directions can provide additional information on bone density and structure. The results of this study should allow development of a clinical prototype for non-invasive assessment of bone strength and fracture risk.

描述（由申请人提供）： 这项研究的长期目标是建立超声作为评估骨折风险的安全、有效和非侵入性方法，这是骨质疏松症临床管理的重要组成部分。在美国，骨质疏松症困扰着超过 2000 万人，每年造成超过 275,000 例髋部骨折。目前，评估的主要手段依赖于光密度技术。这些方法使患者受到电离辐射，相对昂贵，并且并不总能提供良好的骨强度估计。超声波具有多种潜在优势。它是非电离的并且相对便宜。此外，由于超声波是一种机械波，并且以与电磁辐射根本不同的方式与骨骼相互作用，因此与当前的密度测定方法相比，它可能能够提供更准确的骨骼强度估计。这项研究的目标是通过证明超声骨评估新方法的可行性，显着提高当前超声骨评估技术的有效性。该方法需要使用相控阵源和接收器来重复测量指骨（指骨）。此外，该方法利用多向测量来表征小梁（远端和近端）和皮质（骨干）部分。具体目标是 (i) 使用 3D 超声模拟来证明相控阵源和接收器测量可以可重复地估计一组与指骨相关的超声参数； (ii) 结合从两个方向获得的数据可以提供有关骨密度和结构的附加信息。这项研究的结果应该能够开发出用于骨强度和骨折风险非侵入性评估的临床原型。