Ultrasonic Assessment of the Forearm

前臂超声评估

• 批准号: 7427404
• 负责人: Jonathan Kaufman
• 金额: $ 43.35万
• 依托单位: CYBERLOGIC, INC.
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7427404
• 关键词: Address; Applications Grants; Architecture; Bone Density; Bone Mineral Contents; Bone Tissue; Characteristics; Clinical; Clinical Data; Clinical Management; Clinical Research; Clinical Trials; Communities; Computer Simulation; Dependence; Detection; Development; Devices; Diagnosis; Disadvantaged; Disease; Distal; Dual-Energy X-Ray Absorptiometry; Effectiveness; Electromagnetic Energy; Forearm; Fostering; Fracture; Goals; Health Care Costs; Heel; Hip Fractures; Human; Image; Individual; Invasive; Ionizing radiation; Knowledge; Legal patent; Location; Measurement; Measures; Mechanics; Metabolic Bone Diseases; Methods; Monitor; Morbidity - disease rate; Motivation; Multivariate Analysis; Osteoporosis; Patients; Personal Satisfaction; Phalanx; Phase; Play; Primary Care Physician; Principal Investigator; Probability; Property; Publishing; Range; Reporting; Reproducibility; Research; Risk; Risk Assessment; Risk Estimate; Risk Factors; Role; Safety; Score; Screening procedure; Sea; Site; Small Business Funding Mechanisms; Small Business Innovation Research Grant; Spinal Fractures; Structure; System; Techniques; Testing; Tissues; Ultrasonic wave; Ultrasonics; Ultrasonography; United States National Institutes of Health; X-Ray Computed Tomography; base; bone; bone quality; bone strength; calcaneum; computerized data processing; cost; cost effective; design; foot; innovation; instrument; mortality; novel; novel strategies; osteoporosis with pathological fracture; programs; prototype; radius bone structure; response; substantia spongiosa; success; tool

DESCRIPTION (provided by applicant): The long-term objective of this research is to establish ultrasound as a safe, effective, and non-invasive method for assessing fracture risk, an important component in clinical management of osteoporosis. Osteoporosis afflicts over 20 million people in the U.S., responsible for more than 275,000 hip fractures annually. Currently, the primary means for assessment relies on densitometric techniques. These methods subject the patient to ionizing radiation, are relatively expensive, and do not always provide good estimates of bone strength. Ultrasound offers several potential advantages. It is non-ionizing and relatively inexpensive. Moreover, since ultrasound is a mechanical wave and interacts with bone in a fundamentally different manner than electromagnetic radiation, it may be able to provide more accurate estimates of bone strength and fracture risk compared with current densitometric methods. The goal of this research is to develop a new ultrasound system for bone assessment that is not only accurate but also highly reproducible. The system will use the distal forearm as a site of measurement and employ a novel array based parametric signal processing approach which is ideally suited for obtaining high levels of precision. This research should enable the widespread detection of osteoporosis and fracture risk, and will find application not only in the U.S. but worldwide as well. The specific aims in Phase I of this Fast-Track SBIR grant application are to develop a new array-based system for assessing bone in the distal forearm. This will be achieved using computer simulations of ultrasound wave propagation through a set of forearm bones that have been imaged using micro-CT. Following demonstration of feasibility in Phase I, Phase II will then develop a prototype device and test it in a clinical study. The ultimate goal in Phase III is to then commercialize this novel desktop device and to bring it into worldwide use for a simple, safe and effective instrument for fracture risk assessment. As stated by the National Osteoporosis Foundation, osteoporosis is a major public health threat for an estimated 44 million Americans or 55 percent of the people 50 years of age and older. In the U.S., 10 million individuals are estimated to already have the disease and almost 34 million more are estimated to have low bone mass, placing them at increased risk for osteoporosis. While osteoporosis is often thought of as an older person's disease, it can strike at any age. Osteoporosis is responsible for more than 1.5 million fractures annually, including over 300,000 hip fractures and approximately 700,000 vertebral fractures and 250,000 wrist fractures. Notwithstanding these facts, osteoporosis is under-recognized and under-treated. The proposed research should enable bone testing to be done conveniently and safely in a primary care setting. This should lead to earlier detection and treatment and ultimately to reductions in the number of fractures.

描述（由申请人提供）：这项研究的长期目标是将超声确定为评估断裂风险的安全，有效且无创的方法，这是骨质疏松症的临床管理中的重要组成部分。在美国，骨质疏松症折磨了超过2000万人，每年造成超过275,000个髋部骨折。当前，评估的主要手段依赖于光密度计。这些方法使患者接受电离辐射，相对昂贵，并且并不总是提供良好的骨骼强度估计。超声波提供了几种潜在的优势。它是非电源化且相对便宜的。此外，由于超声是一种机械波，并且与电磁辐射的根本不同方式与骨相互作用，因此与当前的密度测定方法相比，它可能能够提供更准确的骨强度和断裂风险的估计。这项研究的目的是开发一种用于骨骼评估的新超声系统，该系统不仅准确，而且高度可重复。该系统将使用远端前臂作为测量部位，并采用新型的基于阵列的参数信号处理方法，非常适合获得高水平的精度。这项研究应该使骨质疏松症和骨折风险的广泛检测能够广泛检测，并且不仅在美国，而且还将在全球范围内找到应用。在此快速轨道SBIR拨款应用程序的I期中，具体目标是开发一种新的基于阵列的系统，以评估远端前臂的骨骼。通过使用Micro-CT成像的一组前臂骨头对超声波传播的计算机模拟将实现这一目标。在证明了第一阶段的可行性之后，第二阶段将开发原型设备并在临床研究中对其进行测试。第三阶段的最终目标是将这种新颖的桌面设备商业化，并将其用于全球用途，以进行简单，安全有效的工具进行断裂风险评估。正如国家骨质疏松基金会所说的那样，骨质疏松症是估计有4400万美国人或50岁以上人群的主要公共卫生威胁。在美国，估计有1000万个人已经患有这种疾病，估计有近3400万人的骨骼质量较低，使骨质疏松症的风险增加。尽管骨质疏松症通常被认为是老年人的疾病，但它可以在任何年龄爆发。骨质疏松症每年造成超过150万个骨折，包括超过300,000个髋部骨折和大约700,000个椎骨骨折和25万手腕骨折。尽管有这些事实，但骨质疏松症的认可和治疗不足。拟议的研究应使在初级保健环境中方便，安全地进行骨测试。这应该导致较早的检测和治疗，最终导致骨折数量减少。