Ultrasonic Assessment of the Forearm

前臂超声评估

基本信息

批准号：
7218910
负责人：
Jonathan Kaufman
金额：
$ 10万
依托单位：
CYBERLOGIC, INC.
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-02-01 至 2007-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7218910
关键词：
Address Age Age-Years American Applications Grants Architecture Bone Density Bone Mineral Contents Bone Tissue Characteristics Clinical Clinical Data Clinical Management Clinical Research Clinical Trials Communities Computer Simulation Dependence Detection Development Devices Diagnosis Disadvantaged Disease Distal Dual-Energy X-Ray Absorptiometry Early Diagnosis Effectiveness Elderly Electromagnetic Energy Employee Strikes Forearm Fostering Foundations Fracture Goals Health Care Costs Heel Hip Fractures Human Image Individual Invasive Ionizing radiation Knowledge Lead Legal patent Location Measurement Measures Mechanics Metabolic Bone Diseases Methods Monitor Morbidity - disease rate Motivation Multivariate Analysis Numbers Osteoporosis Patients Personal Satisfaction Phalanx Phase Play Primary Care Physician Primary Health Care Principal Investigator Probability Property Public Health Publishing Range Reporting Reproducibility Research Risk Risk Assessment Risk Estimate Risk Factors Role Safety Score Screening procedure Sea Site Small Business Funding Mechanisms Small Business Innovation Research Grant Spinal Fractures Structure System Techniques Testing Thinking Tissues Ultrasonic wave Ultrasonics Ultrasonography United States National Institutes of Health X-Ray Computed Tomography base bone bone quality bone strength calcaneum computerized data processing cost cost effective design foot innovation instrument mortality novel novel strategies osteoporosis with pathological fracture programs prototype radius bone structure response substantia spongiosa success tool wrist fracture

项目摘要

DESCRIPTION (provided by applicant): The long-term objective of this research is to establish ultrasound as a safe, effective, and non-invasive method for assessing fracture risk, an important component in clinical management of osteoporosis. Osteoporosis afflicts over 20 million people in the U.S., responsible for more than 275,000 hip fractures annually. Currently, the primary means for assessment relies on densitometric techniques. These methods subject the patient to ionizing radiation, are relatively expensive, and do not always provide good estimates of bone strength. Ultrasound offers several potential advantages. It is non-ionizing and relatively inexpensive. Moreover, since ultrasound is a mechanical wave and interacts with bone in a fundamentally different manner than electromagnetic radiation, it may be able to provide more accurate estimates of bone strength and fracture risk compared with current densitometric methods. The goal of this research is to develop a new ultrasound system for bone assessment that is not only accurate but also highly reproducible. The system will use the distal forearm as a site of measurement and employ a novel array based parametric signal processing approach which is ideally suited for obtaining high levels of precision. This research should enable the widespread detection of osteoporosis and fracture risk, and will find application not only in the U.S. but worldwide as well. The specific aims in Phase I of this Fast-Track SBIR grant application are to develop a new array-based system for assessing bone in the distal forearm. This will be achieved using computer simulations of ultrasound wave propagation through a set of forearm bones that have been imaged using micro-CT. Following demonstration of feasibility in Phase I, Phase II will then develop a prototype device and test it in a clinical study. The ultimate goal in Phase III is to then commercialize this novel desktop device and to bring it into worldwide use for a simple, safe and effective instrument for fracture risk assessment. As stated by the National Osteoporosis Foundation, osteoporosis is a major public health threat for an estimated 44 million Americans or 55 percent of the people 50 years of age and older. In the U.S., 10 million individuals are estimated to already have the disease and almost 34 million more are estimated to have low bone mass, placing them at increased risk for osteoporosis. While osteoporosis is often thought of as an older person's disease, it can strike at any age. Osteoporosis is responsible for more than 1.5 million fractures annually, including over 300,000 hip fractures and approximately 700,000 vertebral fractures and 250,000 wrist fractures. Notwithstanding these facts, osteoporosis is under-recognized and under-treated. The proposed research should enable bone testing to be done conveniently and safely in a primary care setting. This should lead to earlier detection and treatment and ultimately to reductions in the number of fractures.

描述（由申请人提供）：本研究的长期目标是建立超声作为评估骨折风险的安全、有效和非侵入性方法，这是骨质疏松症临床管理的重要组成部分。在美国，骨质疏松症困扰着超过 2000 万人，每年造成超过 275,000 例髋部骨折。目前，评估的主要手段依赖于光密度技术。这些方法使患者受到电离辐射，相对昂贵，并且并不总能提供良好的骨强度估计。超声波具有多种潜在优势。它是非电离的并且相对便宜。此外，由于超声波是一种机械波，并且以与电磁辐射根本不同的方式与骨骼相互作用，因此与当前的密度测量方法相比，它可能能够提供更准确的骨骼强度和骨折风险估计。这项研究的目标是开发一种用于骨骼评估的新型超声系统，该系统不仅准确而且具有高度可重复性。该系统将使用远端前臂作为测量部位，并采用一种新颖的基于阵列的参数信号处理方法，该方法非常适合获得高精度。这项研究应该能够广泛检测骨质疏松症和骨折风险，并将不仅在美国而且在全世界得到应用。快速通道 SBIR 拨款申请第一阶段的具体目标是开发一种新的基于阵列的系统，用于评估前臂远端的骨骼。这将通过计算机模拟超声波通过一组已使用微 CT 成像的前臂骨骼传播来实现。在第一阶段论证可行性后，第二阶段将开发原型设备并在临床研究中进行测试。第三阶段的最终目标是将这种新颖的桌面设备商业化，并将其推向全球，成为一种简单、安全和有效的骨折风险评估仪器。据国家骨质疏松症基金会称，骨质疏松症是估计 4400 万美国人（占 50 岁及以上人群的 55%）的主要公共卫生威胁。在美国，估计有 1000 万人已经患有这种疾病，另有近 3400 万人估计骨量较低，这使得他们患骨质疏松症的风险增加。虽然骨质疏松症通常被认为是老年人的疾病，但它可以发生在任何年龄。骨质疏松症每年导致超过 150 万例骨折，其中包括超过 300,000 例髋部骨折、约 700,000 例椎骨骨折和 250,000 例腕部骨折。尽管有这些事实，骨质疏松症仍未得到充分认识和治疗。拟议的研究应该能够在初级保健环境中方便、安全地进行骨骼测试。这应该会导致及早发现和治疗，并最终减少骨折的数量。