THERMAL CHARACTERIZATION OF HUMAN BREAST TUMORS

人类乳腺肿瘤的热表征

• 批准号: 2715773
• 负责人: KENNETH L CARR
• 金额: $ 35.87万
• 依托单位: MICROWAVE MEDICAL SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-25 至 2000-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2715773
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; body temperature; breast neoplasm /cancer diagnosis; breast neoplasms; clinical biomedical equipment; clinical research; computer assisted diagnosis; computer program /software; diagnosis design /evaluation; diagnosis quality /standard; female; fine needle aspiration; histopathology; human subject; immunocytochemistry; mammography; microwave radiation; neoplasm /cancer blood supply; noninvasive diagnosis; radiography; thermography; thermometry; women's health

The long-term objective of this research is to improve breast cancer management by utilizing thermal information as an adjunct to mammography to aid in clinical decisions when confronted with equivocal mammograms. Before this objective is reached, the relationship of thermal abnormalities to breast cancer must be firmly established. This Phase II proposal is designed to obtain noninvasive thermal information using passive microwave radiometry in both breasts of approximately 1000 women scheduled to have needle localization procedures and breast biopsy. This noninvasive approach is a medically acceptable way to gain the necessary information from both breasts in each patient to permit left- to-right thermal comparisons between the cancer-affected and normal breasts. The strength of this Phase II proposal is that mammograms and biopsy-proven pathology will be available on each case. This will permit correlative studies between breast cancer thermogenicity with other factors, such as tumor histopathology, tumor size, grade and so on, in addition to angiogenesis determined on archival specimens. It may be possible to increase the yield of positive biopsies and reduce negative biopsies if women with equivocal mammograms and thermally abnormal lesions were biopsied, while women with equivocal mammograms and thermally normal lesions were deferred for biopsy pending further evidence indicating biopsy. PROPOSED COMMERCIAL APPLICATION: The long-term objective of this research is to improve breast cancer management by utilizing thermal information as an adjunct to mammography to aid in clinical decisions when confronted with equivocal mammograms. The data obtained from this study could lead to the development of improved detection techniques and equipment, based on noninvasive thermal sensing, as an adjunct to mammography.

这项研究的长期目标是改善乳腺癌 通过利用热信息作为乳房X线摄影的辅助来管理 在面对模棱两可的乳房X线照片时有助于临床决策。 在达到这个目标之前，热关系的关系 必须牢固确定乳腺癌异常。 这个阶段 II提案旨在使用 大约1000名女性的两个乳房中的被动微波辐射指定 计划进行针本定位程序和乳房活检。 这种无创方法是一种获得医学上可接受的方法 来自每个患者的两个乳房的必要信息，以允许左 受癌症影响与正常的右右热比较 乳房。 该II期提议的优势是乳房X线照片和 在每种情况下，都将提供证实活检的病理。 这会 允许与乳腺癌的生态学之间的相关研究 其他因素，例如肿瘤组织病理学，肿瘤大小，等级等 除了在档案标本上确定的血管生成外。 它 可能有可能提高活检的产量并降低 如果具有模棱两可乳房X线照片和热的女性 异常病变是活检的，而乳房X线照片的女性 并将热正常病变推迟以进一步进行活检 表明活检的证据。 拟议的商业应用： 这项研究的长期目标是改善乳腺癌 通过利用热信息作为乳房X线摄影的辅助来管理 在面对模棱两可的乳房X线照片时有助于临床决策。 从这项研究获得的数据可能导致 基于无创的改进的检测技术和设备 热感应，作为乳房X线摄影的辅助。