BRAIN TEMPERATURE MONITORING IN NEONATES

新生儿脑温度监测

• 批准号: 6882239
• 负责人: KENNETH L CARR
• 金额: $ 9.88万
• 依托单位: MERIDIAN MEDICAL SYSTEMS, LLC
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-12-15 至 2005-10-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6882239
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; body temperature; brain; brain disorders; clinical biomedical equipment; cryotherapy; microwave radiation; newborn human (0-6 weeks); patient monitoring device; phantom model; thermometry

DESCRIPTION (provided by applicant): Hypoxic-ischemic encephalopathy (HIE) represents a serious problem in newborns, occurring in 3-9 of every 1000 term infants, with about half of these HIE babies dying or suffering life-long severe handicaps, such as mental retardation or cerebral palsy. Current efforts to reduce the effects of HIE by hypothermia (cooling) have been hampered by the lack of a reliable noninvasive method of monitoring the infant's brain temperature during the hypothermic treatment, which lasts about 48 hours. This proposal will evaluate temperature monitoring using noninvasive dual frequency microwave radiometry of the skull. The Phase I objectives will include: 1) Design of a dual frequency waveguide transducer, 2) Investigation of printed structures for the dual frequency transducer, 3) Development of a sterile disposable interface, 4) Development of a transducer placement monitor to insure proper placement, and 5) Construction of a dielectric phantom and evaluation of thermal patterns using noninvasive radiometry and invasive thermometry. The technical challenge of Phase I lies in the development of the components needed to produce a system which can reliably detect and monitor temperature in the brain tissue, at a depth of at least 15mm, and development of an appropriate model (phantom) and the verification of the EM modeling data.

描述（由申请人提供）： 缺氧缺血性脑病 (HIE) 是新生儿的一个严重问题，每 1000 名足月婴儿中就有 3-9 名发生，其中大约一半的 HIE 婴儿死亡或患有终生严重残疾，例如智力低下或脑瘫。目前，由于缺乏可靠的非侵入性方法来监测持续约 48 小时的低温治疗期间婴儿脑部温度，因此降低低温（冷却）造成的 HIE 影响的努力受到了阻碍。该提案将使用头骨的无创双频微波辐射测量来评估温度监测。第一阶段的目标将包括：1）双频波导换能器的设计，2）研究双频换能器的印刷结构，3）开发无菌一次性接口，4）开发换能器放置监视器以确保正确放置，和 5) 构建介电模型并使用无创辐射测量和有创测温评估热模式。第一阶段的技术挑战在于开发生产系统所需的组件，该系统可以可靠地检测和监测脑组织中至少 15 毫米深度的温度，并开发适当的模型（体模）和验证EM 建模数据。