RAPID THAWING OF FROZEN BLOOD AND BLOOD COMPONENTS

冷冻血液和血液成分的快速解冻

• 批准号: 2867664
• 负责人: KENNETH L CARR
• 金额: $ 9.92万
• 依托单位: MICROWAVE MEDICAL SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-01 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2867664
• 关键词: biomedical equipment development; blood preservation; cryopreservation; electromagnetic radiation; heat; microwave radiation; physical separation; technology /technique development

This proposal defines the need for the development of a device involving safe, rapid and uniform heating to thaw frozen blood and blood components. This device would result in a therapeutically effective product that would reduce the risk of contamination and damage, and significantly increase allowable storage time. Rapid thawing (i.e., less than 5 minutes) is essential. The proposed rapid thawing technique employs an active microwave array in conjunction with radiometric sensing. Each element of the array is, basically, a dual-mode transducer allowing simultaneous microwave heating and radiometric temperature sensing, and further allowing independent control of power at each element. The development and integration of the multi-element array will include the capability to monitor and control the temperature of the entire blood unit. This device for the rapid thawing of frozen blood and blood components may be integrated into a total closed-cell preparation system which includes other functions, such as sterile docking, cell washing and in-line warming. The device is consistent with the NIH objective of developing "equipment and procedures for the collection, separation, processing, preservation, storage and distribution of blood and blood components." PROPOSED COMMERCIAL APPLICATIONS: This device would result in improved health care at significant cost savings since blood components would no longer be thawed well in advance of the need.

该建议定义了开发涉及安全，快速和均匀加热的设备，以解冻冷冻的血液和血液成分。该设备将产生一种治疗有效的产品，可降低污染和损害的风险，并显着增加允许的存储时间。快速解冻（即少于5分钟）是必不可少的。所提出的快速解冻技术与辐射测定相结合采用了活跃的微波阵列。基本上，阵列的每个元素都是双模式传感器，允许同时进行微波加热和辐射温度传感，并进一步允许在每个元素上独立控制功率。多元素阵列的开发和整合将包括监测和控制整个血液单位温度的能力。这种用于快速融化的冷冻血液和血液成分的装置可以集成到总闭孔制备系统中，该系统包括其他功能，例如无菌对接，细胞洗涤和在线变暖。该设备与NIH的目标是一致的，该目标是开发“用于收集，分离，加工，保存，储存，存储和分布血液和血液成分的设备”。拟议的商业应用：此设备将以大量成本节省的成本改善医疗保健，因为血液成分不再需要在需要之前就可以融化。