THERMOMETRY FOR ABLATION OF BENIGN PROSTATIC HYPERPLASIA

良性前列腺增生消融的测温

• 批准号: 6140478
• 负责人: KENNETH L CARR
• 金额: $ 10.01万
• 依托单位: MICROWAVE MEDICAL SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6140478
• 关键词: benign prostate hyperplasia; biomedical equipment development; microwave radiation; neoplasm /cancer thermotherapy; noninvasive diagnosis; patient monitoring device; phantom model; technology /technique development; thermometry; urethra

Benign prostatic hyperplasia (BPH) is a common medical condition in men. The current standard treatment for BPH is transurethral resection of the prostate (TURP). More than 400,000 men in the United States undergo TURP each year. The requirements of general anesthesia and hospitalization for TURP add to the relatively high morbidity and cost of this procedure, fueling the search for less invasive and less costly alternatives. Ablation by microwave energy of the hyperplastic prostatic tissues causing urethral constriction is one such alternative to TURP. Transurethral microwave thermotherapy (TUMT) preserves the integrity of the urethra, reduces morbidity, and can be done without general anesthesia and hospitalization. The success of TUMT is largely dependent on achieving intraprostatic temperatures of 60 - 70 degrees C for about one hour, but no methods are currently available to monitor intraprostatic temperatures noninvasively during treatment. This proposal is intended to develop a noninvasive method of monitoring both urethral and intraprostatic temperature during TUMT through the use of passive microwave radiometry (PMR). PMR has several advantages over existing fiberoptic thermal sensing systems. Although both can measure temperature in a microwave field and not perturb the homogeneity of the field, PMR is less costly, more durable and noninvasive. This technique would permit urologists to accumulate thermal information in a noninvasive way during TUMT which would be more predictive of treatment outcome. PROPOSED COMMERCIAL APPLICATIONS: A reliable noninvasive method of monitoring both urethral and intraprostatic temperature during microwave ablation of BPH has obvious potential for manufacturers of commercially-available microwave ablation systems currently using thermal monitoring methods which are more costly, perturbing to the microwave field, fragile or invasive.

良性前列腺增生（BPH）是男性常见的医疗状况。 BPH的当前标准治疗方法是前列腺（TURP）的尿道切除术。美国每年有40万人经历TURP。全身麻醉和住院对TURP的要求增加了此程序的发病率和成本相对较高，从而助长了侵入性较小和成本较小的替代方案。通过微波能量在产生尿道收缩的增生性前列腺组织的微波能量是TURP的一种替代方法。经尿道微波热疗（TUMT）保留了尿道的完整性，降低发病率，并且可以在没有全身麻醉和住院的情况下进行。 TUMT的成功在很大程度上取决于在大约一个小时内达到60-70摄氏度的肉体内温度，但是目前尚无治疗过程中毫无侵袭的方法来监测肉眼内温度。该建议旨在通过使用被动微波辐射测定法（PMR）开发一种无创方法来监测TUMT期间尿道和脑内温度的方法。 PMR比现有的光纤热传感系统具有多个优势。尽管两者都可以在微波场中测量温度，并且不会扰动该田的同质性，但PMR的成本较低，更耐用和无创。该技术将允许泌尿科医生在TUMT期间以非侵入性的方式积累热信息，这将更加预测治疗结果。拟议的商业应用：一种可靠的无创方法，用于在BPH的微波消融过程中监测尿道和脑内温度，对于当前使用热量较高的热监测方法的商业可用的微波炉消融系统的制造商来说，具有明显的潜力。