THERMOMETRY FOR ABLATION OF BENIGN PROSTATIC HYPERPLASIA

良性前列腺增生消融的测温

• 批准号: 6140478
• 负责人: KENNETH L CARR
• 金额: $ 10.01万
• 依托单位: MICROWAVE MEDICAL SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6140478
• 关键词: benign prostate hyperplasia; biomedical equipment development; microwave radiation; neoplasm /cancer thermotherapy; noninvasive diagnosis; patient monitoring device; phantom model; technology /technique development; thermometry; urethra

Benign prostatic hyperplasia (BPH) is a common medical condition in men. The current standard treatment for BPH is transurethral resection of the prostate (TURP). More than 400,000 men in the United States undergo TURP each year. The requirements of general anesthesia and hospitalization for TURP add to the relatively high morbidity and cost of this procedure, fueling the search for less invasive and less costly alternatives. Ablation by microwave energy of the hyperplastic prostatic tissues causing urethral constriction is one such alternative to TURP. Transurethral microwave thermotherapy (TUMT) preserves the integrity of the urethra, reduces morbidity, and can be done without general anesthesia and hospitalization. The success of TUMT is largely dependent on achieving intraprostatic temperatures of 60 - 70 degrees C for about one hour, but no methods are currently available to monitor intraprostatic temperatures noninvasively during treatment. This proposal is intended to develop a noninvasive method of monitoring both urethral and intraprostatic temperature during TUMT through the use of passive microwave radiometry (PMR). PMR has several advantages over existing fiberoptic thermal sensing systems. Although both can measure temperature in a microwave field and not perturb the homogeneity of the field, PMR is less costly, more durable and noninvasive. This technique would permit urologists to accumulate thermal information in a noninvasive way during TUMT which would be more predictive of treatment outcome. PROPOSED COMMERCIAL APPLICATIONS: A reliable noninvasive method of monitoring both urethral and intraprostatic temperature during microwave ablation of BPH has obvious potential for manufacturers of commercially-available microwave ablation systems currently using thermal monitoring methods which are more costly, perturbing to the microwave field, fragile or invasive.

良性前列腺增生（BPH）是男性常见的疾病。目前 BPH 的标准治疗方法是经尿道前列腺电切术 (TURP)。美国每年有超过 400,000 名男性接受 TURP。 TURP 的全身麻醉和住院要求增加了该手术相对较高的发病率和成本，从而推动了对侵入性较小且成本较低的替代方案的寻找。通过微波能量消融引起尿道收缩的增生性前列腺组织是 TURP 的替代方案之一。经尿道微波热疗 (TUMT) 可以保留尿道的完整性，降低发病率，并且无需全身麻醉和住院即可完成。 TUMT 的成功很大程度上取决于前列腺内温度达到 60 - 70 摄氏度约一小时，但目前没有方法可用于在治疗期间无创监测前列腺内温度。该提案旨在开发一种通过使用被动微波辐射测量 (PMR) 监测 TUMT 期间尿道和前列腺内温度的无创方法。与现有光纤热传感系统相比，PMR 具有多种优势。虽然两者都可以测量微波场中的温度并且不会扰乱场的均匀性，但 PMR 成本更低、更耐用且无创。这项技术将使泌尿科医生能够在 TUMT 期间以无创方式积累热信息，从而更好地预测治疗结果。拟议的商业应用：在 BPH 微波消融期间监测尿道和前列腺内温度的可靠无创方法对于目前使用热监测方法的商用微波消融系统的制造商具有明显的潜力，这些热监测方法成本更高，对微波场有干扰，脆弱或易碎。侵入性的。