Active MEMS Neural Clamps

有源 MEMS 神经钳

• 批准号: 6868269
• 负责人: Ranu Jung
• 金额: $ 18.06万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6868269
• 关键词: Rana; bioengineering /biomedical engineering; biomedical equipment development; body temperature; clinical biomedical equipment; electrodes; electrophysiology; laboratory rat; lumbar plexus; medical implant science; miniature biomedical equipment; neuromuscular stimulator; phrenic nerve; physical property; silicon; spinal nerves; voltage /patch clamp

DESCRIPTION (provided by applicant): ACTIVE MEMS NEURAL CLAMPS In the past decade, significant technological and scientific advances have led to the development of neuroprosthetic devices for motor control. An important aspect in the further advancement of the control systems for such devices will be the ability to obtain stable spatiotemporally distributed recording of neural activity chronically. Similarly, neural interfaces that can provide spatiotemporally distributed stimulation of neural tissue are required. In this project, we are focusing on the development of a novel approach of recording distributed neural activity from the peripheral nervous system, in particular the mammalian spinal roots. The goal is to model, design, fabricate, test and characterize Microelectromechanical System (MEMS) based neural electrodes that actively clamp onto the spinal roots. This clamping mechanism will provide a reversible secure attachment mechanism to ensure reliable recording of the neural signals. The clamping will be driven by the body temperature at site of the implant. The clamping can be temporarily reversed for repositioning during the implant procedure by local perfusion of cooled saline solutions. The fabrication, guided by a finite element modeling approach, will use silicon wafer batch processing techniques that are compatible with integrated circuit manufacturing in order to enable future development of on-chip electronics for filtering, amplification and signal processing. The silicon wafer fabrication also enables future development of low-cost devices. With batch processing, we can vary the electrode and device characteristics on a single wafer to optimize performance. Several electrode configurations on the same device will be evaluated initially using amphibian nerve, then with fixed rodent nerve, and ultimately in real-time by recording autonomous respiratory activity from rat cervical spinal roots and the phrenic nerve. Ability to place the electrodes on multiple lumbosacral spinal roots will be evaluated. These results will guide the redesign of the electrodes. The novel design allows capability for repositioning of multiple spatially distributed implantable electrodes. Such electrodes will advance our capabilities of scientific investigation of neural function in awake subjects and in the development of advanced neuroprosthetic products for rehabilitation.

描述（由申请人提供）：在过去的十年中，主动MEMS神经夹具，重要的技术和科学进步导致了用于运动控制的神经假体设备的开发。该设备控制系统进一步发展的一个重要方面将是能够慢性地获得神经活动的稳定时空分布记录。同样，需要提供时空分布的神经组织刺激的神经界面。在这个项目中，我们关注的是开发一种新的方法，该方法是从周围神经系统（尤其是哺乳动物的脊髓根）记录分布式神经活动的方法。目的是建模，设计，制造，测试和表征基于微电机电系统（MEMS）的神经电极，这些神经电极积极夹在脊髓上。这种夹紧机制将提供可逆的安全依恋机制，以确保对神经信号的可靠记录。夹紧将由植入物部位的体温驱动。可以通过冷却的盐水溶液局部灌注在植入物程序期间暂时逆转夹紧以重新定位。在有限元建模方法的指导下制造将使用与集成电路制造兼容的硅晶粒批处理处理技术，以便能够将来开发芯片电子设备用于过滤，扩增和信号处理。硅晶片制造还可以使低成本设备的未来开发。通过批处理处理，我们可以在单个晶圆上改变电极和设备特性以优化性能。最初将使用两栖神经，然后使用固定的啮齿动物神经来评估同一设备上的几种电极构型，并最终通过记录大鼠宫颈脊髓根和phrenic神经的自主呼吸活性。将评估将电极放置在多个腰椎根部上的能力。这些结果将指导电极的重新设计。新型设计允许重新定位多个空间分布的植入电极。这样的电极将提高我们对清醒受试者神经功能的科学研究以及开发用于康复的高级神经假体产品的能力。