Active MEMS Neural Clamps

有源 MEMS 神经钳

• 批准号: 6868269
• 负责人: Ranu Jung
• 金额: $ 18.06万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6868269
• 关键词: Rana; bioengineering /biomedical engineering; biomedical equipment development; body temperature; clinical biomedical equipment; electrodes; electrophysiology; laboratory rat; lumbar plexus; medical implant science; miniature biomedical equipment; neuromuscular stimulator; phrenic nerve; physical property; silicon; spinal nerves; voltage /patch clamp

DESCRIPTION (provided by applicant): ACTIVE MEMS NEURAL CLAMPS In the past decade, significant technological and scientific advances have led to the development of neuroprosthetic devices for motor control. An important aspect in the further advancement of the control systems for such devices will be the ability to obtain stable spatiotemporally distributed recording of neural activity chronically. Similarly, neural interfaces that can provide spatiotemporally distributed stimulation of neural tissue are required. In this project, we are focusing on the development of a novel approach of recording distributed neural activity from the peripheral nervous system, in particular the mammalian spinal roots. The goal is to model, design, fabricate, test and characterize Microelectromechanical System (MEMS) based neural electrodes that actively clamp onto the spinal roots. This clamping mechanism will provide a reversible secure attachment mechanism to ensure reliable recording of the neural signals. The clamping will be driven by the body temperature at site of the implant. The clamping can be temporarily reversed for repositioning during the implant procedure by local perfusion of cooled saline solutions. The fabrication, guided by a finite element modeling approach, will use silicon wafer batch processing techniques that are compatible with integrated circuit manufacturing in order to enable future development of on-chip electronics for filtering, amplification and signal processing. The silicon wafer fabrication also enables future development of low-cost devices. With batch processing, we can vary the electrode and device characteristics on a single wafer to optimize performance. Several electrode configurations on the same device will be evaluated initially using amphibian nerve, then with fixed rodent nerve, and ultimately in real-time by recording autonomous respiratory activity from rat cervical spinal roots and the phrenic nerve. Ability to place the electrodes on multiple lumbosacral spinal roots will be evaluated. These results will guide the redesign of the electrodes. The novel design allows capability for repositioning of multiple spatially distributed implantable electrodes. Such electrodes will advance our capabilities of scientific investigation of neural function in awake subjects and in the development of advanced neuroprosthetic products for rehabilitation.

描述（由申请人提供）：有源 MEMS 神经夹 在过去的十年中，重大的技术和科学进步导致了用于运动控制的神经假体装置的发展。此类设备控制系统进一步发展的一个重要方面是能够长期获得稳定的时空分布的神经活动记录。同样，需要能够提供神经组织时空分布刺激的神经接口。在这个项目中，我们专注于开发一种记录周围神经系统（特别是哺乳动物脊髓根）分布式神经活动的新方法。目标是对基于微机电系统 (MEMS) 的神经电极进行建模、设计、制造、测试和表征，这些电极主动夹紧脊髓根部。该夹紧机构将提供可逆的安全附着机构，以确保神经信号的可靠记录。夹紧将由植入物部位的体温驱动。在植入过程中，通过局部灌注冷却的盐水溶液，可以暂时反转夹紧以重新定位。该制造以有限元建模方法为指导，将使用与集成电路制造兼容的硅晶圆批量处理技术，以便未来开发用于滤波、放大和信号处理的片上电子器件。硅晶圆制造还使得未来能够开发低成本设备。通过批量处理，我们可以改变单个晶圆上的电极和器件特性以优化性能。同一设备上的几种电极配置将首先使用两栖神经进行评估，然后使用固定的啮齿动物神经进行评估，最后通过记录大鼠颈椎根和膈神经的自主呼吸活动进行实时评估。将评估将电极放置在多个腰骶脊髓根上的能力。这些结果将指导电极的重新设计。这种新颖的设计允许重新定位多个空间分布的植入式电极。此类电极将提高我们对清醒受试者神经功能进行科学研究以及开发用于康复的先进神经假体产品的能力。