NEUROPHYSIOLOGICAL STUDY OF DORSAL SPINOCEREBELLAR TRACT

脊髓小脑背侧束的神经生理学研究

• 批准号: 2264078
• 负责人: RICHARD E POPPELE
• 金额: $ 16.54万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-09 至 1997-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2264078
• 关键词: brain electrical activity; brain mapping; cats; central neural pathway /tract; cerebellum; dorsal column; electrophysiology; electrostimulus; limb movement; neural information processing; neuromuscular function; neurophysiology; sensorimotor system; sensory receptors; sensory signal detection; single cell analysis; spinal cord; spinal cord mapping

The research plan outlined in this proposal is part of a long-range study to understand the role of the cerebellum in the control and regulation of posture and movement. The specific aims of this proposal focus on the organization and representation of sensory information in spinal projection pathways and in the cerebellum. The dorsal spinocerebellar tract (DSCT) transmits to the cerebellum information derived from sensory receptors in muscle, joints and skin of the hind limbs. The content of the signals transmitted and their utilization by the cerebellum are not known, yet these are central to an understanding of cerebellar function as it relates to spinal motor functions. The proposed research will investigate neuronal population behavior in the DSCT and cerebellum by recording from large numbers of randomly sampled neurons, and by using statistical methods based on principal component analysis and correlation analysis. The main issues to be addressed are the nature of the information encoded and the way in which it is encoded. These issues will be examined in the context of a new working hypothesis about the functional role of the spinocerebellar system: It is proposed that the information transmitted by spinocerebellar pathways provides a sensory representation of limb stiffness which may be used to regulate stiffness as a background for posture and movement. Experiments will test specific issues related to this hypothesis. The research is expected to provide new evidence about the role of the nervous system in motor control. Motor control disorders constitute a major health problem with considerable economic consequences. Basic research, such as that proposed here, is needed to understand better the role played by neuronal structures like the spinal cord and the cerebellum in the normal control of posture and movement.

该提案中概述的研究计划是一项长期研究的一部分 了解小脑在控制和调节中的作用 姿势和运动。该提案的具体目的是 脊柱中的感官信息的组织和表示 投影途径和小脑。 背脊椎小区域（DSCT）向小脑发射 来自肌肉，关节和皮肤的感觉受体的信息 后肢。传输的信号的内容及其 小脑利用尚不清楚，但这些都是 了解小脑功能与脊髓电动机有关 功能。 拟议的研究将研究神经元人群行为 DSCT和小脑通过记录大量随机采样 神经元，并通过基于主成分的统计方法 分析和相关分析。要解决的主要问题是 信息的性质编码及其编码方式。 这些问题将在新的工作假设的背景下进行检查 关于脊椎队系统的功能作用：提出 通过脊椎小路传输的信息提供了 肢体刚度的感觉表示，可用于调节 刚度是姿势和运动的背景。实验将测试 与该假设有关的具体问题。这项研究预计将是 提供有关神经系统在电机中的作用的新证据 控制。 运动控制障碍构成了一个主要的健康问题 巨大的经济后果。基础研究，例如提出的 在这里，需要更好地理解神经元所扮演的角色 正常对照中的脊髓和小脑等结构 姿势和运动。