Spectro-temporal and binaural response properties

频谱-时间和双耳响应特性

• 批准号: 7057859
• 负责人: MONTY A ESCABI
• 金额: $ 25.29万
• 依托单位: UNIVERSITY OF CONNECTICUT STORRS
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-15 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7057859
• 关键词: auditory pathways; auditory stimulus; binaural hearing; brain electrical activity; brain mapping; cats; electrophysiology; inferior colliculus; loudness; neural information processing; neural transmission; neuroanatomy; single cell analysis; sound frequency

DESCRIPTION (provided by applicant): The central nucleus of the inferior colliculus (ICC) plays a key role in the acoustic analysis of spectral, temporal and binaural information. Its laminar organization and highly ordered mosaic of converging afferents suggests a critical role in consolidating this acoustic information in the transition to the auditory thalamus. We hypothesize that the distributed layout of spectro-temporal and binaural receptive field features will be systematically ordered in the central nucleus in a manner that reflects the patterns of innervating afferents and the local collicular circuitry. In this study, we propose to characterize the distributed organization of spectro-temporal receptive field (STRF) preferences within the central nucleus. STRF analysis with structured broadband noise will be used to characterize neuronal preferences and to systematically relate these to measurements from conventional pure-tone stimuli. Single unit recording experiments are proposed to characterize the micro-organization of STRF preferences and to identify the roles of receptive field inheritance / construction in the transformation from the brainstem to the central nucleus. Distributed mapping of the ICC will then allow us to simultaneously characterize the global-organization of spectral, temporal and binaural receptive field preferences within the three dimensional structure. Concurrent anatomic studies will show the topographic position of two parallel recording tracks and their respective projections to medial geniculate body. The expected findings will provide a framework for understanding the acoustic analysis of spectro-temporal and binaural features in complex auditory stimuli, which we can then relate to the organizational hierarchy of brainstem inputs, local circuitry, and modular organization.

描述（由申请人提供）：下丘丘（ICC）的中央核在光谱，时间和双耳信息的声学分析中起关键作用。它的层流组织和高度有序的融合传入的马赛克表明，在整合到听觉丘脑的过渡中，这一声学信息至关重要。我们假设光谱和双耳接受场的分布式布局将系统地在中央核中系统排序，以反映神经支配传入的模式和局部胶质电路的模式。在这项研究中，我们建议表征中央核内光谱接受场（STRF）偏好的分布组织。带有结构化宽带噪声的STRF分析将用于表征神经元偏好，并将这些分析系统地与传统的纯音刺激的测量系统联系起来。提出了单个单元记录实验，以表征STRF偏好的微组织，并确定从脑干到中心核的转化中接受场遗传 /构建的作用。然后，ICC的分布式映射将使我们能够同时表征三维结构内光谱，时间和双耳接受场偏好的全局组织。并发的解剖学研究将显示两个平行记录轨道的地形位置及其对内侧基因化体的预测。预期的发现将提供一个框架，以理解复杂听觉刺激中的光谱和双耳特征的声学分析，然后我们可以将其与脑干输入，本地电路和模块化组织的组织层次结构联系起来。