Optical Imaging of Tactile Information in SI Cortex

SI 皮层触觉信息的光学成像

• 批准号: 6801470
• 负责人: ANNA W. ROE
• 金额: $ 35.86万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6801470
• 关键词: Ceboidea; Macaca; anesthesia; brain electrical activity; brain mapping; cats; electrophysiology; fingers; mechanoreceptors; optics; psychophysics; sensation; stimulus /response; three dimensional imaging /topography; touch; vibration perception; wakefulness

DESCRIPTION (provided by applicant): This proposal aims to study the stability of cortical representation by examining cortical maps under different states of anesthesia and alertness (pentothal and isofluane anesthesia, and awake state). Previous studies have hypothesized that different parts of single thalamocortical arbors have different degrees of dominance in Area 3b and that the effects of these secondary arbor inputs may be masked under some conditions and revealed under others. Using optical imaging and electrophysiological methods, we will probe this hypothesis by examining three aspects of finger pad representation in Area 3b and Area 1 of the squirrel monkey: topography, vibrotactile information (pressure SA, flutter RA, and vibration PC), and spatial integration (two digit). We will examine whether digit representation can, in contrast to the standard somatotopic maps, take on non-topographic organizations that are characterized by hotspots and secondary activation zones. We will examine whether SA, RA, and PC inputs can map in both overlapping and segregated manners in the superficial layers. To examine spatial integration in Area 3b and 1, we will examine whether mapping with simultaneous two-finger stimulation paradigm will result in an apparent shift in topography, and whether such a shift is more pronounced in Area 1 and more pronounced in the awake state. These examinations of alternative and shifting topographies are likely to modify the definition of topographic organization in SI and what shifting topographies are likely to modify the definition of topographic organization in SI and what topographic organization is used for in the awake animal. Furthermore, these studies may reveal that the establishment of topography is area-specific and is based on a stimulus-driven or behavior-driven integration of features rather than a simple representation of the sensory epithelium.

描述（由申请人提供）：该提案旨在通过检查麻醉和机敏状态（五刺和异氟烷麻醉和清醒状态）下的皮质图来研究皮质代表的稳定性。先前的研究假设，单个丘脑皮质乔木的不同部分在3B区域中具有不同程度的优势，并且这些次级植物轴的影响可能在某些条件下掩盖并在其他条件下揭示。使用光学成像和电生理方法，我们将通过检查面积3B和Squirrel Monkey区域1的手指垫表示的三个方面来探讨这一假设（两位数）。我们将检查数字表示与标准的体体图相比，是否可以采用以热点和次级激活区为特征的非剧本组织。我们将检查SA，RA和PC输入是否可以在浅层层中的重叠和隔离方式中映射。为了检查3B和1区域中的空间整合，我们将检查同时使用两指刺激范式映射的映射是否会导致地形明显变化，以及在区域1中这种转移是否更为明显，并且在清醒状态下更为明显。这些对替代和不断变化的地形的检查可能会修改SI中地形组织的定义，以及哪些不断变化的地形可能会修改SI中地形组织的定义，以及在清醒动物中使用哪些地形组织。此外，这些研究可能揭示了地形的建立是特定区域的，并且基于刺激驱动或行为驱动的特征的整合，而不是对感觉上皮的简单表示。