Perceptual Circuits in Somatosensory Cortices

体感皮层的知觉回路

• 批准号: 7126283
• 负责人: ANNA W. ROE
• 金额: $ 4.03万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7126283
• 关键词: child rearing; illusions; parents; somesthetic sensory cortex; touch; vibration

DESCRIPTION (provided by applicant): This research will be done in collaboration with Dr. Laszlo Negyessy at Budapest, Hungary at Semmelweis University as an extension of parent grant NIH R01 NS044375 (PI: Anna W. Roe). The goal of the proposed studies is to investigate the neuroanatomical basis of tactile information processing in SI of the squirrel monkey. The goals of the parent grant are to 1) study the functional organization of vibrotactile modality- specific (pressure, flutter, and vibration) representation in Area 3b and 1, and 2) compare the simple vs. complex response preferences in Area 3b and 1. The studies proposed in this Firca will be guided by and integrated with the optical imaging and neurophysiological studies conducted under the parent grant. Neuroanatomical tracer injections (both anterograde and retrograde) will be made into functionally identified domains in Areas 3b and 1. In Aim 1, we will examine modality-specificity of vibrotactile networks within Areas 3b and Area 1. In Aim 2, we will examine topographic specificity of connections within Areas 3b and 1. In Aim 3, in ultrastructural studies, we will examine synaptic relationships of GABAergic targets of synapses formed by the intrinsic-, and interareal connections to help interpret whether functional effects of specific connections are excitatory or inhibitory. These data will provide an anatomical underpinning to imaged vibrotactile networks, to spatial topographies, to functional comparisons between Areas 3b and 1, and to maps of perceptual phenomena such as the funneling illusion. There are very few studies examining local anatomical circuitries within somatosensory cortex and to our knowledge none have been conducted in an integrated fashion with functional studies of local functional organization and perceptual processes. These anatomical data will be highly valuable in their own right, but will be even more so when interpreted in parallel with functional studies in the parent grant.

描述（由申请人提供）：这项研究将与匈牙利布达佩斯 Semmelweis 大学的 Laszlo Negyessy 博士合作完成，作为家长资助 NIH R01 NS044375（PI：Anna W. Roe）的延伸。本研究的目的是研究松鼠猴 SI 触觉信息处理的神经解剖学基础。家长资助的目标是 1) 研究区域 3b 和 1 中振动触觉形态特定（压力、颤动和振动）表示的功能组织，以及 2) 比较区域 3b 和 1 中的简单与复杂响应偏好本 Firca 中提出的研究将受到家长资助下进行的光学成像和神经生理学研究的指导和整合。神经解剖学示踪剂注射（顺行和逆行）将被注入区域 3b 和 1 中的功能识别域。在目标 1 中，我们将检查区域 3b 和区域 1 内振动触觉网络的形态特异性。在目标 2 中，我们将检查地形区域 3b 和 1 内连接的特异性。在目标 3 中，在超微结构研究中，我们将检查由内在和区域间连接形成的突触的 GABA 能靶点，有助于解释特定连接的功能效应是兴奋性还是抑制性。这些数据将为成像振动触觉网络、空间地形、区域 3b 和区域 1 之间的功能比较以及漏斗错觉等感知现象的地图提供解剖学基础。很少有研究检查体感皮层内的局部解剖回路，而且据我们所知，没有一项研究以集成的方式与局部功能组织和知觉过程的功能研究一起进行。这些解剖数据本身就非常有价值，但在与母基金中的功能研究并行解释时更是如此。