Neurophysiological Study of Dorsal Spinocerebellar Tract

脊髓小脑背侧束的神经生理学研究

• 批准号: 6521782
• 负责人: RICHARD E POPPELE
• 金额: $ 28.22万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-09 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6521782
• 关键词: biomechanics; brain mapping; cats; cell population study; central neural pathway /tract; cerebellar Purkinje cell; cerebellum; chordate locomotion; decerebration; dorsal column; limb movement; neural information processing; neuromuscular function; neurons; neurophysiology; posture; proprioception /kinesthesia; psychomotor function; sensorimotor system; single cell analysis; spinal cord

The long term goal of this project is concerned with the neural organization and integration of sensory information used by the nervous system to generate motor commands. The specific aims focus on the organization and representation of sensory information in spinal circuits that project to the cerebellum, to areas involved in the control of posture and locomotion. The dorsal spinocerebellar tract (DSCT) neurons receive sensory information from sensory receptors in the limbs and they convey the results of the spinal processing of this information directly to the spinocerebellum. Although the project is focussed on the spinal cord and its relationship to the cerebellum, it nevertheless addresses central issues about neural processing involved in sensorimotor integration. An underlying perspective guiding this work is that communication among brain areas occurs within common frames of reference. In fact, the relationships found between neural activity and limb kinematics in spinal circuits projecting to the cerebellum resemble in many ways those seen in other brain areas involved in motor behavior. This project will use single neuron recording techniques and multivariate regression analysis to relate neural activity to limb kinematics during passive stepping and self-initiated locomotion in the cat. The results will be used to test specific hypotheses about the spinal and cerebellar organization of sensorimotor systems involved in the control of locomotion. The significance of understanding how these systems are organized is in the potential insight they offer into the workings of the motor control system. Motor disorders account for a large fraction of the disabilities leading to lost productivity or decreased quality of life in this country. A better understanding of the normal function of the motor control system can be expected to lead to improved therapies and rehabilitation strategies even if it does not lead immediately to "cures".

该项目的长期目标与神经系统使用的感官信息的整合有关，用于产生电动机命令。 该特定目的集中在向小脑投射到小脑的脊柱回路中的感官信息，以及涉及控制姿势和运动的领域。背脊髓脑道（DSCT）神经元从四肢的感觉受体接收感官信息，它们将该信息的脊柱加工的结果直接传达给脊椎队。 尽管该项目的重点是脊髓及其与小脑的关系，但它仍然涉及有关接触性烟想整合的神经处理的中心问题。 指导这项工作的基本观点是，大脑区域之间的通信发生在常见的参考框架内。 实际上，投射到小脑的脊柱电路中的神经活动与肢体运动学之间的关系在许多方面都类似于运动行为的其他大脑区域。该项目将使用单个神经元记录技术和多元回归分析，以将神经活动与猫的被动步进和自我引发的运动期间有关。 该结果将用于测试有关涉及移动控制的感觉运动系统的脊柱和小脑组织的特定假设。了解这些系统的组织方式的重要性在于它们对电机控制系统的运作的潜在见解。 运动障碍占残疾的很大一部分，导致该国生产率降低或生活质量下降。 可以更好地理解运动控制系统的正常功能，即使它不会立即导致“治愈”，也可以改善疗法和康复策略。