NEUROPHYSIOLOGICAL STUDY OF DORSAL SPINOCEREBELLAR TRACT

脊髓小脑背侧束的神经生理学研究

• 批准号: 6165400
• 负责人: RICHARD E POPPELE
• 金额: $ 11万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-09 至 2002-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6165400
• 关键词: cats; cerebellum; chordate locomotion; dorsal column; limb movement; neural information processing; neuromuscular function; neurophysiology; sensorimotor system; spinal cord; video recording system

DESCRIPTION (Adapted from applicant's abstract) : The long term goal of this project is to determine how proprioceptive sensory information at the spinal level is organized and integrated for motor control. The specific aims of this proposal focus on the organization and representation of sensory information in spinal projection pathways to the cerebellum, to areas involved in the control of posture and movement. The dorsal spinocerebellar tract (DSCT) transmits to the cerebellum information derived from sensory receptors in muscle, joints and skin of the hindlimbs. The content of the information transmitted and its utilization by the cerebellum are not known, yet these are central to an understanding of cerebellar function as it relates to spinal motor functions. Current results show that DSCT activity encodes the position and trajectory of the hind foot relative to the hip rather than the individual joint angles. This relationship of DSCT activity to whole-limb geometry appears to depend on a mechanical coupling among joint angles that results from the passive mechanical properties of muscles and ligaments spanning more than a single joint. The coupling results in correlated movements across joints which can change, however, depending on the behavioral state. The question addressed in this proposed research is to determine how the differences in joint angle correlations affect DSCT behavior, and whether the effects are attributable to position and movement alone, or also to forces generated by muscle contractions. That is, does the DSCT monitor parameters related to the mechanical compliance of the limb, or simply to its position and movement? This research is expected to provide new evidence about the role of the nervous system in motor control. Motor control disorders constitute a major health problem with considerable economic consequences. Basic research, such as that proposed here, is needed to understand better the role played by neuronal structures like the spinal cord and cerebellum in the normal control of posture and movement.

描述（根据申请人的摘要改编）： 该项目的长期目标是确定本体感受如何 脊柱水平的感官信息是组织的，并集成了 电机控制。 该提案的具体目的集中于组织 并表示脊柱投影途径中的感觉信息 小脑，涉及控制姿势和运动的区域。 背脊椎小区域（DSCT）向小脑发射 来自肌肉，关节和皮肤的感觉受体的信息 后肢。 传输信息的内容及其利用 小脑尚不清楚，但这些都是理解的核心 小脑功能与脊柱运动功能有关。 当前结果表明，DSCT活动编码位置和轨迹 后脚相对于臀部而不是单个关节 角度。 出现了DSCT活性与全LIMB几何形状的这种关系 取决于关节角度之间的机械耦合，这是由 肌肉和韧带的被动机械性能超过了 单关节。 耦合导致关节之间的相关运动 但是，这可能会根据行为状态而改变。 问题 在这项拟议的研究中解决的是确定如何差异 关节角相关性影响DSCT行为，以及效果是否是 仅归因于位置和移动，也归因于 肌肉收缩。 也就是说，DSCT监视器参数是否与 肢体的机械依从性，或者仅仅达到其位置 移动？ 预计这项研究将提供有关该作用的新证据 运动控制中的神经系统。 运动控制障碍构成主要 健康问题带有相当大的经济后果。 基础研究， 例如这里提出的，需要更好地理解发挥的作用 通过神经元结构，如脊髓和小脑在正常 控制姿势和运动。