BEHAVOIRAL MODULATION OF INFERIOR OLIVE RESPONSES

较差橄榄反应的行为调节

• 批准号: 3417032
• 负责人: ALAN R GIBSON
• 金额: $ 10.59万
• 依托单位: ST. JOSEPH'S HOSP/MED CTR (PHOENIX)
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-01-01 至 1992-08-10
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3417032
• 关键词: behavior modification; brain mapping; cats; cerebellum; chordate locomotion; electromyography; electrostimulus; histochemistry /cytochemistry; interneurons; neural inhibition; neuroanatomy; olivary body; psychomotor function; stereotaxic techniques; stimulus /response; videotape /videodisc

The overall goal of our laboratory research is to understand the signals that the nervous system uses to control movements. We are specifically interested in reaching movements, and the participation of one structure, the cerebellum, in the guidance and control of reaching. Cerebellar damage, although causing little cognitive deficits, results in severe deficits in making accurate coordinated reaching movements. Our proposal is to study one of the input systems to the cerebellum, the climbing fiber system, to understand information that it supplies to the cerebellum about movements. We are specifically interested in how motor signals modify the information carried by the climbing fibers, that is, how does output affect input? We have developed a reaching paradigm for cats, that allows us to record from the inferior olive, the source of the climbing fiber system, while the cats reach out to grasp a lever to receive pureed chicken with cod liver oil, a high preference food for cats. During the lever retrieval small perturbations of the arm are introduced with a servo motor. The cats quickly learn to adjust to the perturbation to receive the food. We are interested in the performance of the climbing fiber system during the period of adjustment. Other experiments will be performed in acute anesthetized preparations to define the circuitry responsible for climbing fiber response modification. With advances in technology, there has been much interest in robotics and prosthetic devices. Although we don't feel that mimicking cerebellar action exactly could be accomplished in the foreseeable future, it is quite possible that the overall scheme of motor control used by the nervous system will be valuable in developing efficient robotic devices. No machine can reach out and grasp an object as smoothly or accurately as a human, and this is a basic goal of robotics. It is also one of the movements most needed by paralyzed humans. Another possible application of our research is in neurosurgery. We are located at a Neurological Institute and interact with neurosurgeons on practical problems encountered in the operating room. We have recently completed anatomical work with Drs. Sonntag and Pappas on Bell's Cruciate Palsey, a selective paralysis of the upper limbs. There are suggestions from that work that the paralysis is due to disruption of the cerebellar circuits studied by this proposal.

我们实验室研究的总体目标是了解信号 神经系统用于控制运动。 我们是特别的 有兴趣达到运动，以及一个结构的参与， 小脑，在伸手的指导和控制中。 小脑 损害，尽管几乎没有认知缺陷，但导致严重 使得准确协调的动作缺陷。 我们的建议 是研究小脑的输入系统之一，即攀爬纤维 系统，了解它向小脑提供的信息 动作。 我们对电机信号如何修改 攀岩纤维所携带的信息，即产出如何影响 输入？ 我们已经为猫开发了一个范式，使我们能够记录 从下橄榄，攀岩纤维系统的来源，而 猫伸出手来抓住杠杆，以接收带有鳕鱼肝的泥鸡 石油，猫的高偏好食物。 在杠杆检索期间 手臂的扰动是用伺服电机引入的。 猫 快速学习适应摄动以接收食物。 我们是 对攀岩纤维系统的性能感兴趣 调整期。 其他实验将以急性进行 麻醉准备工作以定义负责攀爬的电路 纤维响应修改。 随着技术的进步，对机器人技术和 假肢设备。 虽然我们不觉得模仿小脑 可以在可预见的未来完成行动，这是非常 神经使用的整体运动控制方案 系统对于开发有效的机器人设备将很有价值。 不 机器可以像 人类，这是机器人技术的基本目标。 它也是 瘫痪的人类最需要的运动。 我们研究的另一个可能应用是神经外科手术。 我们是 位于神经学研究所，并与神经外科医生互动 手术室遇到了实际问题。 我们最近有 与Drs完成了解剖学工作。 Sonntag和Pappas在贝尔十字架上 帕尔西，上肢的选择性瘫痪。 有建议 从这项工作中，瘫痪是由于小脑的破坏而引起的 该提议研究的电路。