NEURAL CONTROL OF THE REACH-TO-GRASP

抓握的神经控制

• 批准号: 6393588
• 负责人: ALAN R GIBSON
• 金额: $ 28.87万
• 依托单位: ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6393588
• 关键词: Primates; cats; electrophysiology; limb movement; neuromuscular function; neuromuscular system; neuroregulation; reticular formation

DESCRIPTION (Adapted from Applicant's Abstract): The overall goal of this research is to understand how the nervous system controls limb movements. The limb movement that we have chosen to study is reaching to grasp an object - a complex task that requires using sensory information to coordinate muscles of the entire limb. The survival of many species, including humans, depends upon performing the reach-to-grasp with speed and accuracy. Despite the importance of the reach-to-grasp, little is known about its control, since few studies have recorded from the nervous system during the reach-to-grasp. Our laboratory has recorded neural activity of single cells in the brains of cats and monkeys while they reach to grasp an object. The data demonstrate that major divisions of the nervous system (intermediate cerebellum and related structures) are involved in control of the grasp but not the reach. That is, different parts of the nervous system control different parts of the movement; this represents an important advance to our understanding of motor control. The research outlined in this proposal will identify parts of the nervous system that control the reach during the reach-to-grasp. Control of the shoulder and muscles of the upper arm depends upon pathways originating in the reticular formation. We will record from neurons in the reticular formation of cats and monkeys while they make the reach-to-grasp and provide information about how reaching is controlled. Anatomical studies will identify neural structures providing input to reticular regions controlling the reach, and we will conduct additional recording studies in those structures to understand how they contribute to the reach-to-grasp. The data will provide the first detailed outline of neural systems controlling a complex forelimb movement and also provide valuable information about how different regions of the brain work together to make movements smooth and precise. Knowledge of how the nervous system controls movement will help us understand, and possibly treat, the diseases and injuries that affect movement and detract from the lives of many people.

描述（改编自申请人的摘要）：此的总体目标 研究是了解神经系统如何控制肢体运动。 我们选择研究的肢体运动正在掌握 对象 - 一个复杂的任务，需要使用感官信息来 协调整个肢体的肌肉。 许多物种的生存， 包括人在内，取决于以速度执行触及式抓地力和 准确性。 尽管触及抓地力很重要，但知之甚少 关于它的控制，因为很少有神经系统的研究 在达到抓地力期间。 我们的实验室记录了 猫和猴子的大脑中的单细胞伸手 目的。 数据表明神经系统的主要分裂 （中间小脑和相关结构）参与 掌握，但没有触及。 也就是说，神经系统的不同部分 控制运动的不同部分；这代表了一个重要的 促进我们对运动控制的理解。 该提案中概述的研究将确定紧张的部分 控制覆盖范围期间触及范围的系统。 控制 上臂的肩膀和肌肉取决于起源于 网状形成。 我们将从网状的神经元中记录 猫和猴子的形成时，它们是触及到抓住并提供的 有关如何控制到达的信息。 解剖学研究将 确定为控制网状区域提供输入的神经结构 覆盖范围，我们将在其中进行其他记录研究 了解它们如何贡献到触手可及的结构。 这 数据将提供控制A神经系统的第一个详细概述 复杂的前肢运动，还提供有关如何 大脑的不同区域一起工作，使运动变得顺利 精确的。 了解神经系统如何控制运动将如何帮助我们 理解并可能治疗影响的疾病和伤害 运动和损害许多人的生活。