NEUROLOGY OF NOVELTY-SEEKING BEHAVIOR AND CURIOSITY

求新行为和好奇心的神经学

• 批准号: 2241031
• 负责人: KIRK R DAFFNER
• 金额: $ 14.25万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-06-01 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2241031
• 关键词: association cortex; attention; brain electrical activity; brain imaging /visualization /scanning; electroencephalography; evoked potentials; exploratory behavior; eye movements; frontal lobe /cortex; human subject; magnetic resonance imaging; neural information processing; neuroanatomy; neuropsychological tests; parietal lobe /cortex; saccades; stimulus /response; stroke; video recording system; visual fixation; visual perception; visual stimulus

Orienting to novelty plays a critical role in directing attention and guiding behavior in normal individuals and is disrupted in many disease states. Yet, little is known about the neural substrate of novelty seeking. The proposed research will investigate the neuroanatomical and electrophysiological underpinning of responses to novel stimuli. Non-brain damaged subjects will be studied to determine the link between early stages of C.N.S. responses to novel stimuli using electrophysiological recordings (as measured by the "novelty" P300) and subsequent stages of information processing and behavioral responses (as measured by subject-controlled stimulus exposure durations). Patients with strokes will be studied to investigate the impact of focal lesions on electrophysiological and behavioral components of novelty seeking and to determine if the frontal cortex plays an essential role in this activity. All subjects will be studied in 1) an Event-Related potential (ERP) Laboratory using specifically designed visual stimuli to evoke different electrophysiological responses and behavioral reactions and 2) an Eye movement Laboratory using visual stimuli to elicit exploratory eye movements. Stroke patients will undergo magnetic resonance imaging (MRI) with 3 dimensional surface reconstruction of the lesion site to precisely delineate the location of structural brain damage.

定向新颖性在引导注意力和 指导正常人的行为，并在许多疾病中受到破坏 国家。 然而，关于新颖的神经基板知之甚少 寻求。 拟议的研究将研究神经解剖学和 对新型刺激的反应的电生理基础。 非脑 将研究受损受试者以确定早期阶段之间的联系 C.N.S.使用电生理记录对新型刺激的反应 （通过“新颖性” P300衡量）和随后的信息阶段 处理和行为响应（如受试者控制 刺激暴露时间）。 将研究中风的患者 研究局灶性病变对电生理学和 寻求新颖性的行为组成部分，并确定额叶是否是否 皮质在这项活动中起着至关重要的作用。 所有主题都是 在1）使用事件相关的电位（ERP）实验室研究 专门设计的视觉刺激以唤起不同的 电生理反应和行为反应以及2）眼睛 使用视觉刺激引起探索性眼睛的运动实验室 动作。 中风患者将进行磁共振成像（MRI） 病变部位的3维表面重建至精确 描述结构性脑损伤的位置。