NEUROLOGY OF ATTENTION TO NOVEL EVENTS

对新事件的注意力的神经学

• 批准号: 2674472
• 负责人: KIRK R DAFFNER
• 金额: $ 14.99万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-06-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2674472
• 关键词: association cortex; attention; behavioral /social science research tag; brain electrical activity; brain imaging /visualization /scanning; electroencephalography; evoked potentials; exploratory behavior; eye movements; frontal lobe /cortex; human subject; magnetic resonance imaging; neural information processing; neuroanatomy; neuropsychological tests; parietal lobe /cortex; saccades; stimulus /response; stroke; video recording system; visual fixation; visual perception; visual stimulus

Orienting to novelty plays a critical role in directing attention and guiding behavior in normal individuals and is disrupted in many disease states. Yet, little is known about the neural substrate of novelty seeking. The proposed research will investigate the neuroanatomical and electrophysiological underpinning of responses to novel stimuli. Non-brain damaged subjects will be studied to determine the link between early stages of C.N.S. responses to novel stimuli using electrophysiological recordings (as measured by the "novelty" P300) and subsequent stages of information processing and behavioral responses (as measured by subject-controlled stimulus exposure durations). Patients with strokes will be studied to investigate the impact of focal lesions on electrophysiological and behavioral components of novelty seeking and to determine if the frontal cortex plays an essential role in this activity. All subjects will be studied in 1) an Event-Related potential (ERP) Laboratory using specifically designed visual stimuli to evoke different electrophysiological responses and behavioral reactions and 2) an Eye movement Laboratory using visual stimuli to elicit exploratory eye movements. Stroke patients will undergo magnetic resonance imaging (MRI) with 3 dimensional surface reconstruction of the lesion site to precisely delineate the location of structural brain damage.

面向新颖性在引导注意力和吸引注意力方面起着至关重要的作用 指导正常个体的行为，但在许多疾病中受到干扰 州。 然而，人们对新颖性的神经基础知之甚少 寻求。 拟议的研究将调查神经解剖学和 对新刺激的反应的电生理学基础。 无脑 将研究受损受试者以确定早期阶段之间的联系 中枢神经系统使用电生理记录对新刺激的反应 （以“新颖性”P300 衡量）和后续阶段的信息 处理和行为反应（通过受试者控制的测量 刺激暴露持续时间）。 将研究中风患者 研究局灶性病变对电生理和电生理的影响 寻求新奇的行为成分并确定额叶是否 皮层在这项活动中起着至关重要的作用。 所有科目都将 在 1) 事件相关电位 (ERP) 实验室中进行研究，使用 专门设计的视觉刺激来唤起不同的感觉 电生理反应和行为反应以及 2) 眼睛 运动实验室使用视觉刺激来引发探索性的眼睛 动作。 中风患者将接受磁共振成像（MRI） 对病变部位进行 3 维表面重建，以精确地 描绘结构性脑损伤的位置。

项目成果

Mechanisms underlying diminished novelty-seeking behavior in patients with probable Alzheimer's disease.

可能患有阿尔茨海默病的患者寻求新奇行为减少的机制。

• 发表时间: 1999
• 期刊: Neuropsychiatry, neuropsychology, and behavioral neurology
• 作者: Daffner,KR;Mesulam,MM;Cohen,LG;Scinto,LF
• 通讯作者: Scinto,LF