SCHIZOPHRENIA AND ACTIVATION DURING SELECTIVE ATTENDING

选择性就读期间的精神分裂症和激活

基本信息

批准号：
6351644
负责人：
Stephan F Taylor
金额：
$ 15.07万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-02-01 至 2002-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6351644
关键词：
adult human (21+) association cortex attention behavioral /social science research tag brain circulation brain imaging /visualization /scanning brain mapping clinical research eye movements functional magnetic resonance imaging human subject neural information processing positron emission tomography psychomotor reaction time schizophrenia sensory cortex visual cortex visual stimulus

项目摘要

DESCRIPTION (Adapted from applicant's abstract): This proposal for a Mentored Clinical Scientist Development Award describes a plan to apply neurobehavioral probes and CBF activation to clinical schizophrenia research. The sponsor, Dr. Rajiv Tandon, will supervise the development of the candidate, Dr. Stephan Taylor. Dr. Tandon will directly train the candidate in clinical schizophrenia research and facilitate his training with Dr. Robert Koeppe, in PET techniques to measure CBF, and with Dr. Sylvan Kornblum, in the cognitive psychology of attention. The training will occur through regular laboratory interactions, during formal coursework through participation in the scientific meetings and during scheduled visits to the laboratories of Drs. Weinberger and Cohen. Knowledge of the mechanism of attentional impairment in schizophrenia may provide important information about the pathophysiology of schizophrenia, since attentional dysfunction may mark vulnerability or trait characteristics of the illness. Attentional dysfunction may occur because of localized abnormalities in central regions or systems which allocate selective attention, e.g., prefrontal cortex, or because of more widespread abnormalities, e.g., from a failure or cortical ontogenesis, which could affect the earliest levels of sensory processing. Preliminary functional neuroimaging data indicate an abnormally hyperactive response of the striate and extra-striate cortex to visual stimuli. Experiments analyzing the response to simple visual stimuli in the striate and extra-striate cortex, with and without attentional modulation, will follow-up preliminary results. This experimental design will aim to determine if attentional impairment in schizophrenia is associated with dysfunction at the level of the sensory cortex or with dysfunction in heteromodal association cortex (e.g., prefrontal cortex), or with abnormal activation in both types of cortex. The successful conclusion of the research plan will provide important clues about pathophysiological mechanisms of this severe and debilitating mental illness. As a result of the proposed training plan, Dr. Taylor should be able to independently pursue further questions that require cognitive psychological frameworks to interpret functional neuroimaging results in psychiatric populations.

描述（改编自申请人的摘要）：本提案针对指导临床科学家发展奖描述了申请计划神经行为探针和 CBF 激活对临床精神分裂症的影响研究。赞助商 Rajiv Tandon 博士将监督该项目的开发候选人斯蒂芬·泰勒博士。 Tandon博士将直接培训临床精神分裂症研究的候选人并促进他的培训与 Robert Koeppe 博士一起研究测量 CBF 的 PET 技术，并与 Dr. Robert Koeppe 一起研究测量 CBF 的 PET 技术。 Sylvan Kornblum，注意力认知心理学。培训内容将在正式课程期间通过定期实验室互动进行通过参加科学会议和定期访问到博士的实验室。温伯格和科恩。了解精神分裂症注意力障碍的机制可能提供有关精神分裂症病理生理学的重要信息，因为注意力功能障碍可能标志着脆弱或特质疾病的特征。可能会出现注意力障碍，因为分配的中央区域或系统的局部异常选择性注意，例如前额皮质，或者因为更广泛异常，例如，由于失败或皮质本体发育，这可能影响最早水平的感觉处理。初步功能神经影像数据表明纹状体反应异常过度活跃和纹状外皮层对视觉刺激的影响。实验分析纹状体和纹状外皮层对简单视觉刺激的反应，有或没有注意力调节，将跟踪初步结果。该实验设计旨在确定注意力是否受损精神分裂症与感觉水平的功能障碍有关皮层或异模式关联皮层功能障碍（例如，前额皮质），或两种类型的皮质均异常激活。研究计划的顺利完成将提供重要线索关于这种严重且衰弱的精神疾病的病理生理机制疾病。根据拟议的培训计划，泰勒博士应该能够独立追求需要认知的进一步问题解释功能性神经影像结果的心理框架精神病人群。