ERP Investigations of Novelty Processing in Aging and AD

老化和 AD 中新颖性处理的 ERP 调查

• 批准号: 6883150
• 负责人: KIRK R DAFFNER
• 金额: $ 41.09万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6883150
• 关键词: Alzheimer' s disease; age difference; aging; attention; behavior test; biological signal transduction; clinical research; cognition; evoked potentials; human middle age (35-64); human old age (65+); human subject; neural information processing; neurophysiology; neuropsychology; psychological concentration; young adult human (21-34)

DESCRIPTION: (provided by applicant) Attention to novel events facilitates adaptation to a changing environment and may increase engagement with one?s surroundings and enhance cognitive abilities. Despite its importance, there has been limited study of age- and disease-related changes in how the brain processes novel events. Based on the PI?s research, a provisional model of a neurally-based novelty processing system is presented. Building upon this work, the proposed research will investigate age-related changes in the novelty P3 response and subsequent allocation of attention to novel stimuli (as measured by viewing durations) in order to elucidate the relationship between responsiveness to novelty and different patterns of cognitive aging. The research aims to distinguish between changes in response to novelty that appear to be inevitable (observed with even the most successful cognitive aging), changes that are most commonly seen with usual cognitive aging, and changes that are associated with the most frequent degenerative disease of the brain (Alzheimer?s disease). A carefully designed series of experiments will test hypotheses about: 1) age-related changes in response to novelty among groups of cognitively high performing individuals; 2) differences in response to novelty between cognitively high and mid performing older individuals; 3) age-related changes in response to novelty among groups of individuals that differ in level of cognitive performance; 4) differences in response to novelty between cognitively normal individuals and cognitively impaired ones (with mild Alzheimer?s disease); and 5) the relationship between the novelty P3 response and subsequent attention to novel events in the laboratory and level of engagement in daily activities. These integrative functional and cognitive neuroscientific studies will extend previous work on the neurology of attention to novel events and provide new insights into the ways in which this fundamental aspect of human behavior is related to normal aging and disease.

描述：（由申请人提供）关注新奇事件有助于 适应不断变化的环境并可能增加与他人的互动 环境并增强认知能力。尽管它很重要，但有 对年龄和疾病相关的大脑如何变化的研究还很有限。 处理新事件。根据 PI 的研究，建立了一个临时模型 提出了基于神经网络的新颖性处理系统。在此工作的基础上， 拟议的研究将调查新奇的 P3 与年龄相关的变化 对新刺激的反应和随后的注意力分配（根据测量 通过查看持续时间）以阐明之间的关系 对新鲜事物的反应和不同的认知衰老模式。这 研究旨在区分因出现的新颖性而产生的变化 是不可避免的（即使是最成功的认知老化也可以观察到）， 通常认知老化中最常见的变化，以及 与最常见的大脑退行性疾病有关 （阿尔茨海默病）。 精心设计的一系列实验将检验以下假设：1) 认知能力高的群体对新鲜事物的反应与年龄相关的变化 表演个人； 2）对新鲜事物的反应存在差异 认知能力较高和中等的老年人； 3）与年龄有关的变化 响应不同水平的个体群体之间的新奇事物 认知表现； 4）对新鲜事物的反应差异 认知正常的个体和认知受损的个体（轻度 阿尔茨海默病）； 5）新颖性P3响应之间的关系 以及随后对实验室中的新事件和水平的关注 参与日常活动。这些综合功能和认知 神经科学研究将扩展先前关于注意力神经学的工作 新颖的事件并提供新的见解 人类行为的基本方面与正常衰老和疾病有关。