ERP Investigations of Novelty Processing in Aging and AD

老化和 AD 中新颖性处理的 ERP 调查

• 批准号: 7056072
• 负责人: KIRK R DAFFNER
• 金额: $ 40.12万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7056072
• 关键词: Alzheimer' s disease; age difference; aging; attention; behavior test; biological signal transduction; clinical research; cognition; evoked potentials; human middle age (35-64); human old age (65+); human subject; neural information processing; neurophysiology; neuropsychology; psychological concentration; young adult human (21-34)

DESCRIPTION: (provided by applicant) Attention to novel events facilitates adaptation to a changing environment and may increase engagement with one?s surroundings and enhance cognitive abilities. Despite its importance, there has been limited study of age- and disease-related changes in how the brain processes novel events. Based on the PI?s research, a provisional model of a neurally-based novelty processing system is presented. Building upon this work, the proposed research will investigate age-related changes in the novelty P3 response and subsequent allocation of attention to novel stimuli (as measured by viewing durations) in order to elucidate the relationship between responsiveness to novelty and different patterns of cognitive aging. The research aims to distinguish between changes in response to novelty that appear to be inevitable (observed with even the most successful cognitive aging), changes that are most commonly seen with usual cognitive aging, and changes that are associated with the most frequent degenerative disease of the brain (Alzheimer?s disease). A carefully designed series of experiments will test hypotheses about: 1) age-related changes in response to novelty among groups of cognitively high performing individuals; 2) differences in response to novelty between cognitively high and mid performing older individuals; 3) age-related changes in response to novelty among groups of individuals that differ in level of cognitive performance; 4) differences in response to novelty between cognitively normal individuals and cognitively impaired ones (with mild Alzheimer?s disease); and 5) the relationship between the novelty P3 response and subsequent attention to novel events in the laboratory and level of engagement in daily activities. These integrative functional and cognitive neuroscientific studies will extend previous work on the neurology of attention to novel events and provide new insights into the ways in which this fundamental aspect of human behavior is related to normal aging and disease.

描述：（申请人提供）对新事件的关注有助于 适应不断变化的环境，并可能增加与一个环境的参与 环境并增强认知能力。尽管很重要，但 对年龄和疾病相关的大脑的变化的研究有限 处理新事件。基于Pi的研究，这是一个的临时模型 提出了基于神经的新颖性处理系统。在这项工作的基础上 拟议的研究将研究与年龄相关的新颖性P3变化 响应和随后对新刺激的注意力分配（如测量 通过查看持续时间）为了阐明 对新颖性和认知衰老不同模式的反应。这 研究旨在区分出现新颖性的变化 不可避免（即使是最成功的认知衰老也可以观察到） 通常从通常的认知衰老和变化中最常见的变化 与大脑最常见的退行性疾病有关的 （阿尔茨海默氏病）。 精心设计的一系列实验将测试有关：1） 认知高度群体之间与新颖性有关的年龄相关变化 表演个人； 2）对新奇的响应差异 认知高和中期的年龄较大的人； 3）与年龄有关的变化 响应于不同程度不同的个体群体的新颖性 认知表现； 4）对新颖性的差异 认知正常人和认知受损的人（轻度 阿尔茨海默氏病）； 5）新颖性P3响应之间的关系 随后关注实验室和水平的新事件 参与日常活动。这些综合功能和认知 神经科学研究将扩展有关注意力的神经学 进行新颖事件，并提供有关此方式方式的新见解 人类行为的基本方面与正常衰老和疾病有关。