New York Regional Center for Diabetes Translation Research

纽约糖尿病翻译研究区域中心

• 批准号: 10290456
• 负责人: Carmen R. Isasi
• 金额: $ 12.74万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-20 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10290456
• 关键词: Address; Adult; Affect; Ancillary Study; Applications Grants; Area; Award; Awareness; Behavioral Sciences; Biological; Communities; Consult; Consultations; Data; Data Set; Databases; Diabetes Mellitus; Diabetes prevention; Dominican; Electronic Mail; Evaluation; Faculty; Fostering; Funding; Genetic; Health; Health system; Healthcare; Healthcare Systems; Hispanic Community Health Study/Study of Latinos; Hispanics; Individual; Interest Group; Intervention; Latino; Lead; Life Cycle Stages; Life Style; Medicine; Mentorship; Methodology; Mexican; Minority; Minority Groups; Modeling; New York; Not Hispanic or Latino; Obesity; Outcome; Participant; Pathway interactions; Phenotype; Plant Roots; Population; Prediabetes syndrome; Prevalence; Process; Program Development; Program Evaluation; Provider; Puerto Rican; Quality of life; Research; Research Personnel; Research Support; Research Training; Resources; Sampling; Science; South American; Structural Racism; Students; Technology; Training Activity; Translational Research; Ursidae Family; Visit; Youth; base; biopsychosocial; cardiovascular risk factor; career development; cohort; combat; community engaged research; community engagement; design; diabetes control; diabetes management; diabetes risk; eHealth; follow-up; health care service; health disparity; improved; innovation; insight; meetings; member; multidisciplinary; novel; offspring; phenotypic data; population health; psychosocial; racial and ethnic; research data dissemination; secondary analysis; social culture; social determinants; special interest group; success; virtual

Latino Network for Diabetes Translation Research – A National Resource Core The Latino population is the largest ethnic/racial minority group in the U.S. and is projected to continue to grow, as the U.S. transitions to a “majority-minority nation.” Latinos clearly bear a disproportionate burden of diabetes, as compared to non-Hispanic whites. The landmark Hispanic Community Health Study/Study of Latinos (HCHS/SOL) of 16,415 Latino adults from four U.S. field centers showed an overall diabetes prevalence of 16.9% with more than 41% undiagnosed, and low levels of diabetes control. The causes of Latino diabetes disparities include social determinants with their roots in structural racism, as well as psychosocial, lifestyle, biological and genetic pathways. To combat diabetes disparities and improve quality of life in US Latinos, innovative, culturally appropriate approaches are needed that address multi-level targets, partner with community entities, and apply state of science technologies. In the proposed renewal of the New York Regional Center for Diabetes Translation Research (NY-CDTR), we will build on our successful Latino Network for Diabetes Translation Research – a National Resource Core (“Latino Network Core”) supporting type 2 to 4 translational research that focuses on cutting-edge diabetes prevention and management approaches with emphasis on sociocultural adaptation for U.S. Latinos. We will continue to leverage resources and expertise of the HCHS/SOL which now includes six years of longitudinal follow-up (with a third, 12-year follow-up in process) and rich phenotypic and genetic data from multiple ancillary studies relevant to diabetes translational research across the life course. In addition, we expand the Latino Network Core’s investigator expertise in culturally appropriate interventions targeting diabetes prevention, management, and healthcare services. Expertise in cultural tailoring, community engaged research, eHealth approaches, and the use of pragmatic interventions in real-world healthcare contexts will help guide maximally effective, sustainable, and innovative translational research in Latinos. In this cycle, we seek to: 1) Further develop the Latino Network Core, building national capacity for diabetes translational research among Latinos, by engaging new members (with special emphasis on early stage investigators and those who are underrepresented in medicine), leading research dissemination and training activities, and convening scientific interest group discussions and themed meetings; 2) Foster novel research focused on understanding Latino diabetes health and disparities and identifying modifiable targets for intervention, by facilitating access to the richly characterized HCHS/SOL datasets and other resources; and 3) Provide consultation and mentorship on study conceptualization, design, assessment, and evaluation for type 2 to 4 translational research on diabetes prevention, management, and healthcare services in Latinos. By capitalizing on HCHS/SOL resources and our specialized expertise in culturally informed interventions to improve health and healthcare among Latinos with or at risk for diabetes, the evolved Latino Network Core will significantly extend the reach and impact of the NY-CDTR in promoting type 2 to 4 diabetes translational research at the national level.

拉丁裔糖尿病翻译研究网络——国家资源核心 拉丁裔人口是美国最大的族裔/种族少数群体，预计将继续 随着美国向“少数族裔占多数的国家”转型，拉丁裔显然承受着不成比例的负担。 与非西班牙裔白人相比，具有里程碑意义的西班牙裔社区健康研究/研究。 来自美国四个现场中心的 16,415 名拉丁裔成年人中的拉丁裔 (HCHS/SOL) 显示总体患有糖尿病 患病率为 16.9%，其中超过 41% 未确诊，糖尿病控制水平较低。 拉丁裔糖尿病差异包括根源于结构性种族主义的社会决定因素，以及 心理社会、生活方式、生物和遗传途径，以消除糖尿病差异并提高治疗质量。 在美国拉丁美洲人的生活中，需要创新的、文化上适当的方法来解决多层次的目标， 与社区实体合作，并在新的拟议更新中应用科学技术。 约克糖尿病翻译研究区域中心 (NY-CDTR)，我们将在成功的拉丁裔基础上再接再厉 糖尿病翻译研究网络 – 国家资源核心（“拉丁裔网络核心”）支持 专注于尖端糖尿病预防和管理的 2 至 4 类转化研究 我们将继续利用资源，重点关注美国拉丁裔的社会文化适应。 和 HCHS/SOL 的专业知识，现在包括六年的纵向随访（第三次为期 12 年） 正在进行中的后续行动）以及来自与糖尿病相关的多项辅助研究的丰富表型和遗传数据 此外，我们还扩大了拉丁裔网络核心的研究人员。 针对糖尿病预防、管理和医疗保健的文化适当干预措施的专业知识 文化定制、社区参与研究、电子医疗方法和使用方面的专业知识。 在现实世界的医疗保健环境中采取务实的干预措施将有助于指导最大限度地有效、可持续和 拉丁裔的创新转化研究 在这个周期中，我们寻求： 1) 进一步发展拉丁裔网络。 核心，通过吸引新成员来建设拉美裔糖尿病翻译研究的国家能力 （特别强调早期研究人员和那些在医学领域代表性不足的人）， 研究传播和培训活动，以及召开科学兴趣小组讨论和主题 会议；2) 促进重点了解拉丁裔糖尿病健康状况和差异的新颖研究； 通过促进获得特征丰富的 HCHS/SOL 来确定可修改的干预目标 数据集和其他资源；3) 提供研究概念化、设计、 糖尿病预防、管理和治疗的 2 至 4 类转化研究的评估和评估 通过利用 HCHS/SOL 资源和我们的专业知识，为拉丁裔提供医疗保健服务。 以文化为基础的干预措施，以改善患有糖尿病或有糖尿病风险的拉丁美洲人的健康和医疗保健， 不断发展的拉丁裔网络核心将显着扩大 NY-CDTR 在促进 国家级2-4型糖尿病转化研究。