Social Stress, Epigenetics and Cardiometabolic Health Among Youth

青少年的社会压力、表观遗传学和心脏代谢健康

• 批准号: 10569070
• 负责人: Carmen R. Isasi
• 金额: $ 65.89万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-17 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10569070
• 关键词: Acceleration; Acculturation; Address; Adolescent; Adult; Affect; Age; Area; Behavioral; Biological; Biological Assay; Biological Process; Birth Place; Blood specimen; Buffers; Cardiovascular Diseases; Cardiovascular system; Child; Child Health; Childhood; Chronic; Chronic Disease; Chronic stress; Communities; Conflict (Psychology); Country; DNA; DNA Damage; DNA Methylation; Data; Development; Diabetes Mellitus; Discrimination; Economics; Environment; Epigenetic Process; Ethnic Population; Exposure to; Family; Genetic Transcription; Glucocorticoids; Health; High Prevalence; Hispanic Community Health Study/Study of Latinos; Hispanic Populations; Hydrocortisone; Hypertension; Inflammation; Intervention; Latino; Latino Population; Life; Life Cycle Stages; Link; Lipids; Mendelian randomization; Mental Health; Methods; Methylation; Mitochondria; Mitochondrial DNA; Molecular; Nature; Obesity; Outcome; Participant; Pathway interactions; Pattern; Physiological; Play; Policies; Poverty; Process; Race; Research; Resource Allocation; Risk; Role; Sampling; Shapes; Signal Transduction; Skin; Social Environment; Socioeconomic Status; Stress; Stressful Event; Techniques; United States; Vulnerable Populations; Youth; cardiometabolism; cardiovascular health; cardiovascular risk factor; caregiving; cohort; epigenomics; ethnic identity; ethnic minority population; experience; food insecurity; genome wide methylation; health disparity; health disparity populations; novel; offspring; racial population; resilience; social; social stress; social stressor; sociocultural determinant; socioeconomics; stressor

Project Summary There is extensive evidence that economic and social stressors shape the development of cardiovascular disease starting early in the life course. However, it is largely unknown how social and economic stressors affect biological processes, particularly at the cellular level and whether these processes are evident among children and adolescents. Latinos, the largest and fastest growing ethnic minority group in the United States, have a high prevalence of cardiovascular risk factors and experience higher rates of poverty and social stressors in both childhood and adulthood compared to other racial/ethnic groups. One novel method to evaluate possible mechanisms underlying the associations between stressors and cardiovascular health across the life course is DNA methylation. Recently a handful of small studies have found that stressful experiences may alter DNA methylation, thus providing a potential mechanism by which social stressors may get under the skin. We propose to examine the association between social stressors, in relation to DNA methylation, mitochondrial DNA (mtDNA) damage and cardiometabolic health, among children participating in the Hispanic Community Health Study /Study of Latinos (HCHS/SOL) Youth Study. The HCHS/SOL Youth study is a study of US Latinos, representing varied countries of origin, conducted in the US. We propose to use existing data from 1200 participants who completed the HCH/SOL Youth study and who provided blood samples. Existing blood samples will be assayed for DNA methylation age, genome-wide methylation and a mtDNA damage marker. Cardiometabolic health markers (obesity, diabetes, hypertension, inflammation and lipids) have also been assessed. Existing data also includes assessments of current family environment as well as socio-cultural factors among children. Specifically, we will examine 1) whether social and economic stressors are associated with DNA methylation age, mtDNA damage and genome-wide methylation; 2) whether DNA methylation age, genome-wide methylation and mtDNA damage is associated with cardiometabolic health among children and 3) whether socio-cultural factors (i.e, ethnic identity, parental closeness, place of birth) modify the association between social and economic stress and DNA methylation and mtDNA damage association. We will furthermore implement mendelian randomization techniques to address the cross-sectional nature of the data. Completion of this project would allow us to elucidate the impact social and economic stressors have on epigenetic and cardiometabolic markers that may help explain how stress shapes persistent population health disparities among Latino populations.

项目概要 有大量证据表明经济和社会压力因素影响心血管疾病的发展 疾病在生命历程的早期开始。然而，目前尚不清楚社会和经济压力如何 影响生物过程，特别是在细胞水平以及这些过程是否明显 儿童和青少年之间。拉丁裔是世界上最大且增长最快的少数族裔群体 美国心血管危险因素患病率较高，贫困率较高 与其他种族/族裔群体相比，儿童期和成年期的社会压力源。一本小说 评估压力源与压力源之间关联的可能机制的方法 整个生命过程中的心血管健康取决于DNA甲基化。最近一些小型研究 发现压力经历可能会改变 DNA 甲基化，从而提供了一种潜在的机制： 哪些社会压力可能会影响我们的情绪。我们建议研究社会之间的关联 压力源，与 DNA 甲基化、线粒体 DNA (mtDNA) 损伤和心脏代谢健康有关， 参加西班牙裔社区健康研究/拉丁裔研究 (HCHS/SOL) 青少年的儿童 学习。 HCHS/SOL 青年研究是一项针对美国拉丁裔的研究，代表不同的原籍国， 在美国进行。我们建议使用 1200 名完成 HCH/SOL 的参与者的现有数据 青少年研究以及谁提供了血液样本。将检测现有血液样本的 DNA 甲基化 年龄、全基因组甲基化和 mtDNA 损伤标记。心脏代谢健康指标（肥胖、 糖尿病、高血压、炎症和血脂）也进行了评估。现有数据还包括 对儿童当前家庭环境以及社会文化因素的评估。具体来说， 我们将研究 1) 社会和经济压力是否与 DNA 甲基化年龄相关， mtDNA 损伤和全基因组甲基化； 2) DNA甲基化年龄、全基因组是否 甲基化和 mtDNA 损伤与儿童心脏代谢健康相关，3) 是否 社会文化因素（即种族认同、父母亲密度、出生地）改变了两者之间的关联 社会和经济压力与 DNA 甲基化和 mtDNA 损伤的关联。我们还将进一步 实施孟德尔随机化技术来解决数据的横截面性质。 该项目的完成将使我们能够阐明社会和经济压力因素对 表观遗传和心脏代谢标记物可能有助于解释压力如何塑造持久人口 拉丁裔人口之间的健康差异。