New York Regional Center for Diabetes Translation Research

纽约糖尿病翻译研究区域中心

• 批准号: 10290454
• 负责人: Carmen R. Isasi
• 金额: $ 10.29万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-20 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10290454
• 关键词: Acceleration; Address; Adult; Age; Attention; Behavior; Behavior Therapy; Behavioral; Biological; Biological Factors; Biological Markers; Biological Process; Child; Consultations; Data; Development; Diabetes Mellitus; Diabetes prevention; Elderly; Ensure; Funding; Future; Goals; Health; Individual; Infrastructure; Institution; Intervention; Investigation; Lead; Life; Life Cycle Stages; Longevity; Low Income Population; Measures; Mediating; Mentorship; Methodology; Methods; Modeling; New York; Observational Study; Outcome; Pathway interactions; Pattern; Phase; Plant Roots; Policies; Population; Population Heterogeneity; Positioning Attribute; Prevention; Primary Prevention; Process; Research; Research Design; Research Personnel; Resources; Risk Factors; Secondary Prevention; Services; Shapes; Skin; Structure; Translational Research; Translations; United States National Institutes of Health; Work; age group; biopsychosocial; cohort; critical period; design; diabetes control; disorder risk; efficacious intervention; experience; health disparity; health equity; health inequalities; implementation facilitation; improved; instrument; member; middle age; mobile computing; modifiable risk; multidisciplinary; novel; prevent; programs; racial and ethnic; racial and ethnic disparities; resilience; social factors; social health determinants; stressor; success; tertiary prevention; theories

Life Course Methodology Core The overall goal of the Life Course Methodology Core (LCMC) of the New York Regional Center for Diabetes Translation Research is to support high quality type 2 translational research in diabetes prevention and control across the life span. The life course perspective focuses on the biopsychosocial and behavioral processes that individuals experience during particular periods in their life, and examines the interplay between these exposures in shaping disease risk. Currently, there is strong evidence from observational studies that the processes that lead to the development of diabetes start early in life and continue throughout the lifespan. This life course approach also can enhance the translation of efficacious interventions by ensuring that intervention strategies are appropriate for the age group targeted and address associated individual or environmental barriers. Following this line of thought, we propose a two pronged approach that identifies the most relevant modifiable risk factors and the most appropriate interventions taking into account the life stage targeted. The LCMC will leverage existing multidisciplinary expertise and infrastructure to facilitate application of a life course perspective to new translational diabetes research. Einstein investigators and their collaborators have accumulated decades of expertise in diabetes research across the life span and are well positioned to contribute to the acceleration of translational research. The LCMC will provide conceptual and instrumental support regarding the design, and implementation of new translational diabetes research across the life span with the ultimate goal of decreasing the burden of diabetes and alleviating diabetes health disparities. The LCMC specific aims are: 1) To build capacity in using the life course approach to the design of new translational diabetes research; 2) To facilitate the implementation of new translational diabetes research; 3) To provide consultation and mentorship on biological factors underlying diabetes health disparities across the lifespan.

生命历程方法论核心 纽约区域中心生命历程方法学核心（LCMC）的总体目标 糖尿病转化研究旨在支持糖尿病预防领域的高质量 2 型转化研究 并在整个生命周期内进行控制。生命历程视角侧重于生物心理社会和行为 个人在生命中特定时期经历的过程，并检查之间的相互作用 这些暴露会影响疾病风险。目前，观察性研究有强有力的证据表明 导致糖尿病发展的过程在生命早期就开始并持续整个生命周期。这 生命全程方法还可以通过确保干预措施的实施来增强有效干预措施的转化 策略适合目标年龄组并针对相关的个人或环境 障碍。遵循这一思路，我们提出了一种双管齐下的方法，以确定最相关的 可改变的风险因素和考虑到目标生命阶段的最适当的干预措施。这 LCMC 将利用现有的多学科专业知识和基础设施来促进生命历程的应用 新转化糖尿病研究的视角。爱因斯坦的研究人员和他们的合作者 在整个生命周期中积累了数十年的糖尿病研究专业知识，并且有能力 有助于加速转化研究。 LCMC 将提供概念和工具 支持整个生命周期的新转化糖尿病研究的设计和实施 最终目标是减轻糖尿病负担并缩小糖尿病健康差距。这 LCMC 的具体目标是： 1) 建设使用生命历程方法设计新产品的能力 转化糖尿病研究； 2）促进新的转化糖尿病研究的实施； 3） 就糖尿病健康差异背后的生物因素提供咨询和指导 寿命。