Living Well: A Web-based Intervention to Improve Quality of Life in Rural and Urban Ovarian Cancer Survivors

美好生活：基于网络的干预措施，提高农村和城市卵巢癌幸存者的生活质量

基本信息

批准号：
10547784
负责人：
SUSAN K LUTGENDORF
金额：
$ 60.26万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-02-01 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10547784
关键词：
Age Animals Anxiety Attention Behavioral Biological Process Cancer Patient Cancer Survivor Cancer Survivorship Caring Chronic Clinic Clinical Cognitive Coping Skills Data Development Diagnosis Disease Disease Progression Distress Elements Fatigue Goals Gynecologic Oncology Health Benefit Health Promotion Home Incidence Internet Intervention Longterm Follow-up Malignant Female Reproductive System Neoplasm Malignant Neoplasms Malignant neoplasm of ovary Mediating Mental Depression Moods Online Systems Outcome Outcome Measure Participant Patients Population Prognosis Public Health Quality of life Randomized, Controlled Trials Recurrence Relaxation Reporting Research Rural Site Social isolation Stress Support System Survival Rate Survivors Symptoms Targeted Research Testing Time Travel Tumor Promotion Videoconferencing Woman Work acceptability and feasibility active control cohort coping depressive symptoms direct application efficacy evaluation evidence base experience health related quality of life implementation barriers improved in vitro Model innovation intervention effect mindfulness mindfulness-based stress reduction novel perceived stress physical symptom poor sleep primary outcome programs psychosocial rural setting secondary outcome side effect skills stress management stress reduction symposium therapy design tumor progression urban residence web-based intervention

项目摘要

Abstract Over the last two decades, we and others have documented the chronic and often debilitating experience of ovarian cancer survivorship which may include poor health related quality of life (HRQOL), elevated anxiety and depression, poor sleep, fatigue, multiple symptoms/side effects, existential concerns, and a generally poor prognosis. Because of compromises to many aspects of HRQOL combined with low rates of survival for the majority of these patients, development of innovative approaches for improving HRQOL and potentially improving clinical outcomes is of paramount importance. This need is particularly true in rural settings where women may have less access to clinic-based support systems. Despite the multiple challenges experienced by ovarian cancer survivors, research targeting the potential efficacy of psychosocial interventions in enhancing HRQOL has been extremely limited. Over the last several years this research team has developed and piloted a web-based group conferencing intervention entitled Living Well (Web-Enhanced Lessons for Living) targeting key concerns of ovarian cancer survivors and developed with input from survivors. The overarching goal of the present submission is to examine the efficacy of the Living Well intervention vs. a Health Promotion active control intervention in a randomized controlled trial in 256 ovarian cancer survivors who have completed primary treatment and are less than 5-years post-diagnosis. We hypothesize that the Living Well Intervention will be efficacious in improving HRQOL, decreasing perceived stress (primary outcomes) and in decreasing depressive mood, anxiety, and fatigue (secondary outcomes). This application is highly innovative because it combines elements of evidence-based psychosocial interventions in a novel way to target the needs of ovarian cancer survivors, using a state-of-the-art web and video conferencing platform that allows wide dissemination, including to rural survivors. This work is highly translational as it is a direct application of findings from mechanistic stress-related research to testing an intervention to reduce stress in ovarian cancer survivors. The significance of the application is that this intervention has the potential to overcome prior barriers to the implementation of such psychosocial interventions and improve HRQOL, thus providing public health benefits to an understudied and compromised cancer population with a high likelihood of recurrence.

抽象的在过去的二十年中，我们和其他人都记录了长期且经常使人衰弱的经历卵巢癌幸存者的身份可能包括健康相关的生活质量（HRQOL），升高焦虑和抑郁，睡眠不良，疲劳，多种症状/副作用，存在性关注和通常预后不良。由于HRQOL的许多方面的妥协与低率相结合大多数患者的生存，开发了改善HRQOL的创新方法潜在地改善临床结果至关重要。这种需求在妇女可能无法获得基于诊所的支持系统的农村环境。尽管有倍数卵巢癌幸存者面临的挑战，研究针对的潜在功效增强HRQOL的社会心理干预措施极为有限。在过去的几年中该研究团队已经开发并驾驶了一个基于网络的小组会议干预措施，标题为生活良好（用于生活的网络增强课程）针对卵巢癌幸存者和由幸存者的投入而开发。本提交的总体目标是检查生活井干预的疗效与健康促进的主动控制干预措施在完成初级治疗且小于256个卵巢癌幸存者的对照试验中诊断后5年。我们假设生活井干预将有效地改善 HRQOL，减轻感知的压力（主要结果），并减少抑郁情绪，焦虑，和疲劳（次要结果）。该应用具有高度创新性，因为它结合了以一种新颖的方式针对卵巢癌幸存者需求的新方法，以证据为基础的社会心理干预措施，使用最先进的网络和视频会议平台，该平台允许广泛传播，包括农村幸存者。这项工作是高度转化的，因为它是机械发现的直接应用与压力有关的研究，以测试一种干预措施，以减少卵巢癌幸存者的压力。这该应用的重要性是，此干预措施有可能克服先前的障碍实施此类社会心理干预措施并改善HRQOL，从而提供公共卫生对经过较高复发的可能性很小的癌症人群的良好益处。