Development of a Web-Based Group Intervention to Support Ovarian Cancer Survivors

开发基于网络的团体干预来支持卵巢癌幸存者

• 批准号: 9047253
• 负责人: SUSAN K LUTGENDORF
• 金额: $ 7.96万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-06 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9047253
• 关键词: Adverse effects; Animals; Anxiety; Behavioral; Binding Sites; Biological Markers; Cancer Patient; Cancer Survivor; Cancer Survivorship; Cells; Chronic; Cognitive; Data; Development; Disease Progression; Distress; Elements; Fatigue; Feedback; Future; Goals; Gynecologic; Health; Health Benefit; Home environment; In Vitro; Incidence; Internet; Intervention; Interview; Laboratories; Life; Link; Malignant Female Reproductive System Neoplasm; Malignant Neoplasms; Malignant neoplasm of ovary; Malignant neoplasm of prostate; Meditation; Mental Depression; Morbidity - disease rate; Neuropathy; Online Systems; Pathway interactions; Patient Outcomes Assessments; Patients; Persons; Physiological; Physiological Adaptation; Population; Positioning Attribute; Process; Psychosocial Factor; Public Health; Quality of life; Randomized Clinical Trials; Recurrence; Relaxation; Research; Site; Sleep; Sleep disturbances; Social isolation; Social support; Stress; Survival Rate; Symptoms; Targeted Research; Testing; Travel; Woman; Work; base; biobehavior; chemotherapy; clinical practice; clinically relevant; depressive symptoms; direct application; experience; field study; group intervention; immune function; improved; innovation; intervention program; malignant breast neoplasm; mindfulness; mindfulness-based stress reduction; mood symptom; outcome forecast; programs; psychosocial; stress management; symposium; tumor progression; usability

 DESCRIPTION (provided by applicant): Ovarian cancer is the second most common gynecologic cancer; however, more women die annually from ovarian cancer than from cancers of all other gynecologic sites combined. Ovarian cancer survivors often experience high levels of distress, sleep disturbances, fatigue, neuropathies, multiple symptoms and side effects, and existential concerns, along with a generally poor prognosis. Additionally, we have documented strong links between psychosocial factors and physiological pathways related to disease progression in ovarian cancer. Because of compromises to many aspects of quality of life (QOL) combined with low rates of survival for the majority of these patients, development of innovative approaches for improving QOL is of paramount importance, but research examining the potential efficacy of psychosocial interventions in ovarian cancer survivors has been extremely limited. Barriers to development of an in-person intervention have included low populations of ovarian cancer survivors at any one site and debility of patients. Based on focus interview feedback from ovarian cancer survivors, we have been developing an intervention targeted to ovarian cancer survivors, drawing from key elements of Cognitive Behavioral Stress Management (CBSM) and Mindfulness-Based Stress Reduction (MBSR) along with some of the value-based content of Acceptance and Commitment Therapy (ACT). Over the last year we have developed a mobile responsive web platform to deliver a live web-based conferencing psychosocial intervention that ovarian cancer patients can access from their homes. The primary goal of this application is further development, web deployment, field usability, and field testing of this intervention among ovarian cancer survivors. The ultimate goal of this program of research will be to conduct a larger scale randomized clinical trial of this intervention using web delivery, with examination of mood, symptoms, and QOL along with clinically relevant endpoints and biomarkers. The significance of the application is that this intervention has the potential to improve quality of life of ovarian cancer survivors and may have the ability to lengthen the period of recurrence free survival.

 描述（由适用提供）：卵巢癌是第二大最常见的妇科癌症；但是，每年从卵巢癌中死亡的女性比所有其他妇科癌症的癌症都多。卵巢癌的存活通常经常经历高水平的困扰，睡眠障碍，疲劳，神经病，多种症状和副作用以及现有的关注以及预后较差。此外，我们已经记录了社会心理因素与与卵巢癌疾病进展有关的身体途径之间的牢固联系。由于大多数患者的生活质量（QOL）的许多方面（QOL）以及较低的生存率妥协，因此发展了改善QOL的创新方法的发展至关重要，但是研究研究心理社会干预对卵巢癌的潜在有效性的研究非常有限。面对面干预发展的障碍包括任何一个地点的卵巢癌存活率和患者自由度。基于卵巢癌存活的重点访谈反馈，我们一直在开发针对卵巢癌存活的干预措施，从认知行为压力管理（CBSM）的关键要素（CBSM）和基于正念的压力减轻（MBSR）以及一些基于价值的接受和承诺治疗（ACT）以及一些基于价值的含义（ACT）。在过去的一年中，我们开发了一个移动响应式网络平台，以提供基于Web的实时会议的社会心理干预措施，卵巢癌患者可以从他们的家中使用。该应用程序的主要目标是进一步开发，网络部署，现场可用性和字段 测试卵巢癌存活中这种干预措施。该研究计划的最终目标是使用Web进行此干预的大规模随机临床试验 通过检查情绪，症状和QoL以及临床相关的终点和生物标志物的交付。应用的意义在于，此干预有可能 提高卵巢癌存活的生活质量，并可能具有延长无复发生存期的能力。